The contribution of chemokines and migration to the induction of central tolerance in the thymus

The contribution of chemokines and migration to the induction of central tolerance in the thymus

As T cells develop, they migrate throughout the thymus where they undergo essential bi-directional signaling with stromal cells in distinct thymic microenvironments. Immature thymocyte progenitors are located in the thymic cortex. Following T cell receptor expression and positive selection, thymocyt...

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Bibliographic Details
Main Authors: Zicheng eHu, Jessica Naomi Lancaster, Lauren I R Ehrlich
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Immunology
Subjects:
Central Tolerance
Chemokine receptors
Thymus
negative selection
Thymocyte migration
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00398/full

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