Evaluation of Two Different Strategies for Schistosomiasis Screening in High-Risk Groups in a Non-Endemic Setting
A consensus on the recommended screening algorithms for schistosomiasis in asymptomatic high-risk subjects in non-endemic areas is lacking. The objective of this study was to evaluate the real-life performance of direct microscopy and ELISA serology for schistosomiasis screening in a high-risk popul...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
|
| Series: | Tropical Medicine and Infectious Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2414-6366/8/1/44 |
| _version_ | 1797436722439520256 |
|---|---|
| author | Luisa Roade Elena Sulleiro Cristina Bocanegra Fernando Salvador Begoña Treviño Francesc Zarzuela Lidia Goterris Nuria Serre-Delcor Inés Oliveira-Souto Maria Luisa Aznar Diana Pou Adrián Sánchez-Montalvà Pau Bosch-Nicolau Juan Espinosa-Pereiro Israel Molina |
| author_facet | Luisa Roade Elena Sulleiro Cristina Bocanegra Fernando Salvador Begoña Treviño Francesc Zarzuela Lidia Goterris Nuria Serre-Delcor Inés Oliveira-Souto Maria Luisa Aznar Diana Pou Adrián Sánchez-Montalvà Pau Bosch-Nicolau Juan Espinosa-Pereiro Israel Molina |
| author_sort | Luisa Roade |
| collection | DOAJ |
| description | A consensus on the recommended screening algorithms for schistosomiasis in asymptomatic high-risk subjects in non-endemic areas is lacking. The objective of this study was to evaluate the real-life performance of direct microscopy and ELISA serology for schistosomiasis screening in a high-risk population in a non-endemic setting. A retrospective cohort study was conducted in two out-patient Tropical Medicine units in Barcelona (Spain) from 2014 to 2017. Asymptomatic adults arriving from the Sub-Saharan region were included. Schistosomiasis screening was conducted according to clinical practice following a different strategy in each setting: (A) feces and urine direct examination plus <i>S. mansoni</i> serology if non-explained eosinophilia was present and (B) <i>S. mansoni</i> serology plus uroparasitological examination as the second step in case of a positive serology. Demographic, clinical and laboratory features were collected. Schistosomiasis cases, clinical management and a 24 month follow-up were recorded for each group. Four-hundred forty individuals were included. The patients were mainly from West African countries. Fifty schistosomiasis cases were detected (11.5% group A vs. 4 % group B, <i>p</i> = 0.733). When both microscopic and serological techniques were performed, discordant results were recorded in 18.4% (16/88). Schistosomiasis cases were younger (<i>p</i> < 0.001) and presented eosinophilia and elevated IgE (<i>p</i> < 0.001) more frequently. Schistosomiasis is a frequent diagnosis among high-risk populations. Serology achieves a similar performance to direct diagnosis for the screening of schistosomiasis in a high-risk population. |
| first_indexed | 2024-03-09T11:05:42Z |
| format | Article |
| id | doaj.art-f9659e50c7854ea0b6e8cad619dc0f33 |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-09T11:05:42Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-f9659e50c7854ea0b6e8cad619dc0f332023-12-01T00:58:19ZengMDPI AGTropical Medicine and Infectious Disease2414-63662023-01-01814410.3390/tropicalmed8010044Evaluation of Two Different Strategies for Schistosomiasis Screening in High-Risk Groups in a Non-Endemic SettingLuisa Roade0Elena Sulleiro1Cristina Bocanegra2Fernando Salvador3Begoña Treviño4Francesc Zarzuela5Lidia Goterris6Nuria Serre-Delcor7Inés Oliveira-Souto8Maria Luisa Aznar9Diana Pou10Adrián Sánchez-Montalvà11Pau Bosch-Nicolau12Juan Espinosa-Pereiro13Israel Molina14Internal Medicine Department, University Hospital Vall d’Hebron, 08035 Barcelona, SpainMicrobiology Department, University Hospital Vall d’Hebron, PROSICS Barcelona, 08035 Barcelona, SpainTropical Medicine and International Health Unit Vall d’Hebron-Drassanes, Infectious Diseases Department, University Hospital Vall d’Hebron, PROSICS Barcelona, 08035 Barcelona, SpainTropical Medicine and International Health Unit Vall d’Hebron-Drassanes, Infectious Diseases Department, University Hospital Vall d’Hebron, PROSICS Barcelona, 08035 Barcelona, SpainTropical Medicine and International Health Unit Vall d’Hebron-Drassanes, Infectious Diseases Department, University Hospital Vall d’Hebron, PROSICS Barcelona, 08035 Barcelona, SpainMicrobiology Department, University Hospital Vall d’Hebron, PROSICS Barcelona, 08035 Barcelona, SpainMicrobiology Department, University Hospital Vall d’Hebron, PROSICS Barcelona, 08035 Barcelona, SpainTropical Medicine and International Health Unit Vall d’Hebron-Drassanes, Infectious Diseases Department, University Hospital Vall d’Hebron, PROSICS Barcelona, 08035 Barcelona, SpainTropical Medicine and International Health Unit Vall d’Hebron-Drassanes, Infectious Diseases Department, University Hospital Vall d’Hebron, PROSICS Barcelona, 08035 Barcelona, SpainTropical Medicine and International Health Unit Vall d’Hebron-Drassanes, Infectious Diseases Department, University Hospital Vall d’Hebron, PROSICS Barcelona, 08035 Barcelona, SpainTropical Medicine and International Health Unit Vall d’Hebron-Drassanes, Infectious Diseases Department, University Hospital Vall d’Hebron, PROSICS Barcelona, 08035 Barcelona, SpainTropical Medicine and International Health Unit Vall d’Hebron-Drassanes, Infectious Diseases Department, University Hospital Vall d’Hebron, PROSICS Barcelona, 08035 Barcelona, SpainTropical Medicine and International Health Unit Vall d’Hebron-Drassanes, Infectious Diseases Department, University Hospital Vall d’Hebron, PROSICS Barcelona, 08035 Barcelona, SpainTropical Medicine and International Health Unit Vall d’Hebron-Drassanes, Infectious Diseases Department, University Hospital Vall d’Hebron, PROSICS Barcelona, 08035 Barcelona, SpainTropical Medicine and International Health Unit Vall d’Hebron-Drassanes, Infectious Diseases Department, University Hospital Vall d’Hebron, PROSICS Barcelona, 08035 Barcelona, SpainA consensus on the recommended screening algorithms for schistosomiasis in asymptomatic high-risk subjects in non-endemic areas is lacking. The objective of this study was to evaluate the real-life performance of direct microscopy and ELISA serology for schistosomiasis screening in a high-risk population in a non-endemic setting. A retrospective cohort study was conducted in two out-patient Tropical Medicine units in Barcelona (Spain) from 2014 to 2017. Asymptomatic adults arriving from the Sub-Saharan region were included. Schistosomiasis screening was conducted according to clinical practice following a different strategy in each setting: (A) feces and urine direct examination plus <i>S. mansoni</i> serology if non-explained eosinophilia was present and (B) <i>S. mansoni</i> serology plus uroparasitological examination as the second step in case of a positive serology. Demographic, clinical and laboratory features were collected. Schistosomiasis cases, clinical management and a 24 month follow-up were recorded for each group. Four-hundred forty individuals were included. The patients were mainly from West African countries. Fifty schistosomiasis cases were detected (11.5% group A vs. 4 % group B, <i>p</i> = 0.733). When both microscopic and serological techniques were performed, discordant results were recorded in 18.4% (16/88). Schistosomiasis cases were younger (<i>p</i> < 0.001) and presented eosinophilia and elevated IgE (<i>p</i> < 0.001) more frequently. Schistosomiasis is a frequent diagnosis among high-risk populations. Serology achieves a similar performance to direct diagnosis for the screening of schistosomiasis in a high-risk population.https://www.mdpi.com/2414-6366/8/1/44schistosomiasisnon-endemicdiagnosis |
| spellingShingle | Luisa Roade Elena Sulleiro Cristina Bocanegra Fernando Salvador Begoña Treviño Francesc Zarzuela Lidia Goterris Nuria Serre-Delcor Inés Oliveira-Souto Maria Luisa Aznar Diana Pou Adrián Sánchez-Montalvà Pau Bosch-Nicolau Juan Espinosa-Pereiro Israel Molina Evaluation of Two Different Strategies for Schistosomiasis Screening in High-Risk Groups in a Non-Endemic Setting Tropical Medicine and Infectious Disease schistosomiasis non-endemic diagnosis |
| title | Evaluation of Two Different Strategies for Schistosomiasis Screening in High-Risk Groups in a Non-Endemic Setting |
| title_full | Evaluation of Two Different Strategies for Schistosomiasis Screening in High-Risk Groups in a Non-Endemic Setting |
| title_fullStr | Evaluation of Two Different Strategies for Schistosomiasis Screening in High-Risk Groups in a Non-Endemic Setting |
| title_full_unstemmed | Evaluation of Two Different Strategies for Schistosomiasis Screening in High-Risk Groups in a Non-Endemic Setting |
| title_short | Evaluation of Two Different Strategies for Schistosomiasis Screening in High-Risk Groups in a Non-Endemic Setting |
| title_sort | evaluation of two different strategies for schistosomiasis screening in high risk groups in a non endemic setting |
| topic | schistosomiasis non-endemic diagnosis |
| url | https://www.mdpi.com/2414-6366/8/1/44 |
| work_keys_str_mv | AT luisaroade evaluationoftwodifferentstrategiesforschistosomiasisscreeninginhighriskgroupsinanonendemicsetting AT elenasulleiro evaluationoftwodifferentstrategiesforschistosomiasisscreeninginhighriskgroupsinanonendemicsetting AT cristinabocanegra evaluationoftwodifferentstrategiesforschistosomiasisscreeninginhighriskgroupsinanonendemicsetting AT fernandosalvador evaluationoftwodifferentstrategiesforschistosomiasisscreeninginhighriskgroupsinanonendemicsetting AT begonatrevino evaluationoftwodifferentstrategiesforschistosomiasisscreeninginhighriskgroupsinanonendemicsetting AT francesczarzuela evaluationoftwodifferentstrategiesforschistosomiasisscreeninginhighriskgroupsinanonendemicsetting AT lidiagoterris evaluationoftwodifferentstrategiesforschistosomiasisscreeninginhighriskgroupsinanonendemicsetting AT nuriaserredelcor evaluationoftwodifferentstrategiesforschistosomiasisscreeninginhighriskgroupsinanonendemicsetting AT inesoliveirasouto evaluationoftwodifferentstrategiesforschistosomiasisscreeninginhighriskgroupsinanonendemicsetting AT marialuisaaznar evaluationoftwodifferentstrategiesforschistosomiasisscreeninginhighriskgroupsinanonendemicsetting AT dianapou evaluationoftwodifferentstrategiesforschistosomiasisscreeninginhighriskgroupsinanonendemicsetting AT adriansanchezmontalva evaluationoftwodifferentstrategiesforschistosomiasisscreeninginhighriskgroupsinanonendemicsetting AT pauboschnicolau evaluationoftwodifferentstrategiesforschistosomiasisscreeninginhighriskgroupsinanonendemicsetting AT juanespinosapereiro evaluationoftwodifferentstrategiesforschistosomiasisscreeninginhighriskgroupsinanonendemicsetting AT israelmolina evaluationoftwodifferentstrategiesforschistosomiasisscreeninginhighriskgroupsinanonendemicsetting |