Pulmonary lymphangitic carcinomatosis secondary to ureteral cancer
Background: Pulmonary lymphangitic carcinomatosis (PLC) is a metastatic lung disease of malignant tumors that spread through pulmonary lymphatic vessels. Although prompt diagnosis and specific treatment of PLC are required due to the poor prognosis associated with this disease, it is often challengi...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Respiratory Medicine Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007121000101 |
| _version_ | 1818742126687551488 |
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| author | Hiroshi Sugimoto Keisuke Sugimoto Haruna Inoue Ryuichiro Tanaka Kyosuke Nakata Takeshi Okino Yoshihisa Kinoshita Kazuhiro Kajimoto |
| author_facet | Hiroshi Sugimoto Keisuke Sugimoto Haruna Inoue Ryuichiro Tanaka Kyosuke Nakata Takeshi Okino Yoshihisa Kinoshita Kazuhiro Kajimoto |
| author_sort | Hiroshi Sugimoto |
| collection | DOAJ |
| description | Background: Pulmonary lymphangitic carcinomatosis (PLC) is a metastatic lung disease of malignant tumors that spread through pulmonary lymphatic vessels. Although prompt diagnosis and specific treatment of PLC are required due to the poor prognosis associated with this disease, it is often challenging to determine the primary cancer site. Case presentation: A 67-year-old Japanese woman presented to our hospital with a 10-day history of cough and dyspnea on exertion. Chest radiography and computed tomography (CT) revealed diffuse nodular opacities with interlobular septal thickening. Both bronchoalveolar lavage (BAL) and transbronchial lung biopsy (TBLB) revealed carcinoma cells with unknown origin. Contrast-enhanced CT depicted a mass in the right ureter with hydronephrosis, and retrograde urography showed a narrowing of the right ureter. Urine cytology from her right ureter via ureteral catheter also revealed atypical cells, highly suggestive of malignancy. Immunohistochemical examination of lung specimens via TBLB showed results consistent with lung metastasis of ureteral cancer. Therefore, we arrived at a diagnosis of PLC secondary to ureteral cancer. Conclusions: This case encouraged multidisciplinary discussion and a whole-body examination, including TBLB with immunohistochemistry, to determine the origin of PLC. |
| first_indexed | 2024-12-18T02:07:34Z |
| format | Article |
| id | doaj.art-f9669106c6a842d48a44135755292d1b |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-12-18T02:07:34Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-f9669106c6a842d48a44135755292d1b2022-12-21T21:24:34ZengElsevierRespiratory Medicine Case Reports2213-00712021-01-0132101348Pulmonary lymphangitic carcinomatosis secondary to ureteral cancerHiroshi Sugimoto0Keisuke Sugimoto1Haruna Inoue2Ryuichiro Tanaka3Kyosuke Nakata4Takeshi Okino5Yoshihisa Kinoshita6Kazuhiro Kajimoto7Department of Respiratory Medicine, Kobe Red Cross Hospital, Kobe, Japan; Corresponding author. Department of Respiratory Medicine, Kobe Red Cross Hospital, 1-3-1 Wakinohama Kaigan-dori, Chuo-ku, Kobe, 651-0073, Japan.Department of Respiratory Medicine, Kobe Red Cross Hospital, Kobe, JapanDepartment of Respiratory Medicine, Kobe Red Cross Hospital, Kobe, JapanDepartment of Respiratory Medicine, Kobe Red Cross Hospital, Kobe, JapanDepartment of Respiratory Medicine, Kobe Red Cross Hospital, Kobe, JapanDepartment of Pathology, Kobe Red Cross Hospital, Kobe, JapanDepartment of Urology, Kobe Red Cross Hospital, Kobe, JapanDepartment of Respiratory Medicine, Kobe Red Cross Hospital, Kobe, JapanBackground: Pulmonary lymphangitic carcinomatosis (PLC) is a metastatic lung disease of malignant tumors that spread through pulmonary lymphatic vessels. Although prompt diagnosis and specific treatment of PLC are required due to the poor prognosis associated with this disease, it is often challenging to determine the primary cancer site. Case presentation: A 67-year-old Japanese woman presented to our hospital with a 10-day history of cough and dyspnea on exertion. Chest radiography and computed tomography (CT) revealed diffuse nodular opacities with interlobular septal thickening. Both bronchoalveolar lavage (BAL) and transbronchial lung biopsy (TBLB) revealed carcinoma cells with unknown origin. Contrast-enhanced CT depicted a mass in the right ureter with hydronephrosis, and retrograde urography showed a narrowing of the right ureter. Urine cytology from her right ureter via ureteral catheter also revealed atypical cells, highly suggestive of malignancy. Immunohistochemical examination of lung specimens via TBLB showed results consistent with lung metastasis of ureteral cancer. Therefore, we arrived at a diagnosis of PLC secondary to ureteral cancer. Conclusions: This case encouraged multidisciplinary discussion and a whole-body examination, including TBLB with immunohistochemistry, to determine the origin of PLC.http://www.sciencedirect.com/science/article/pii/S2213007121000101Pulmonary lymphangitic carcinomatosisUreteral cancerBronchoalveolar lavageTransbronchial lung biopsyImmunohistochemistry |
| spellingShingle | Hiroshi Sugimoto Keisuke Sugimoto Haruna Inoue Ryuichiro Tanaka Kyosuke Nakata Takeshi Okino Yoshihisa Kinoshita Kazuhiro Kajimoto Pulmonary lymphangitic carcinomatosis secondary to ureteral cancer Respiratory Medicine Case Reports Pulmonary lymphangitic carcinomatosis Ureteral cancer Bronchoalveolar lavage Transbronchial lung biopsy Immunohistochemistry |
| title | Pulmonary lymphangitic carcinomatosis secondary to ureteral cancer |
| title_full | Pulmonary lymphangitic carcinomatosis secondary to ureteral cancer |
| title_fullStr | Pulmonary lymphangitic carcinomatosis secondary to ureteral cancer |
| title_full_unstemmed | Pulmonary lymphangitic carcinomatosis secondary to ureteral cancer |
| title_short | Pulmonary lymphangitic carcinomatosis secondary to ureteral cancer |
| title_sort | pulmonary lymphangitic carcinomatosis secondary to ureteral cancer |
| topic | Pulmonary lymphangitic carcinomatosis Ureteral cancer Bronchoalveolar lavage Transbronchial lung biopsy Immunohistochemistry |
| url | http://www.sciencedirect.com/science/article/pii/S2213007121000101 |
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