CD62L expression marks a functionally distinct subset of memory B cells
Summary: The memory B cell response consists of phenotypically distinct subsets that differ in their ability to respond upon antigen re-encounter. However, the pathways regulating the development and function of memory B cell subsets are poorly understood. Here, we show that CD62L and CD44 are progr...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723015541 |
| _version_ | 1827593691250819072 |
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| author | Christopher H. Hanson Brittany Henry Pradhnesh Andhare Frank J. Lin Haley Pak Jackson S. Turner Lucas J. Adams Tom Liu Daved H. Fremont Ali H. Ellebedy Brian J. Laidlaw |
| author_facet | Christopher H. Hanson Brittany Henry Pradhnesh Andhare Frank J. Lin Haley Pak Jackson S. Turner Lucas J. Adams Tom Liu Daved H. Fremont Ali H. Ellebedy Brian J. Laidlaw |
| author_sort | Christopher H. Hanson |
| collection | DOAJ |
| description | Summary: The memory B cell response consists of phenotypically distinct subsets that differ in their ability to respond upon antigen re-encounter. However, the pathways regulating the development and function of memory B cell subsets are poorly understood. Here, we show that CD62L and CD44 are progressively expressed on mouse memory B cells and identify transcriptionally and functionally distinct memory B cell subsets. Bcl6 is important in regulating memory B cell subset differentiation with overexpression of Bcl6 resulting in impaired CD62L+ memory B cell development. Bcl6 regulates memory B cell subset development through control of a network of genes, including Bcl2 and Zeb2. Overexpression of Zeb2 impairs the development of CD62L+ memory B cells. Importantly, CD62L is also differentially expressed on human memory B cells following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and identifies phenotypically distinct populations. Together, these data indicate that CD62L expression marks functionally distinct memory B cell subsets. |
| first_indexed | 2024-03-09T02:15:25Z |
| format | Article |
| id | doaj.art-f9679ad7b80f45a38c364d2b3c151f7a |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-09T02:15:25Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-f9679ad7b80f45a38c364d2b3c151f7a2023-12-07T05:28:33ZengElsevierCell Reports2211-12472023-12-014212113542CD62L expression marks a functionally distinct subset of memory B cellsChristopher H. Hanson0Brittany Henry1Pradhnesh Andhare2Frank J. Lin3Haley Pak4Jackson S. Turner5Lucas J. Adams6Tom Liu7Daved H. Fremont8Ali H. Ellebedy9Brian J. Laidlaw10Department of Medicine, Washington University School of Medicine, St. Louis, MO, USADepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USADepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USADepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USADepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USADepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USADepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USADepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USADepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USADepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO, USA; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, Saint Louis, MO, USADepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA; Corresponding authorSummary: The memory B cell response consists of phenotypically distinct subsets that differ in their ability to respond upon antigen re-encounter. However, the pathways regulating the development and function of memory B cell subsets are poorly understood. Here, we show that CD62L and CD44 are progressively expressed on mouse memory B cells and identify transcriptionally and functionally distinct memory B cell subsets. Bcl6 is important in regulating memory B cell subset differentiation with overexpression of Bcl6 resulting in impaired CD62L+ memory B cell development. Bcl6 regulates memory B cell subset development through control of a network of genes, including Bcl2 and Zeb2. Overexpression of Zeb2 impairs the development of CD62L+ memory B cells. Importantly, CD62L is also differentially expressed on human memory B cells following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and identifies phenotypically distinct populations. Together, these data indicate that CD62L expression marks functionally distinct memory B cell subsets.http://www.sciencedirect.com/science/article/pii/S2211124723015541CP: Immunology |
| spellingShingle | Christopher H. Hanson Brittany Henry Pradhnesh Andhare Frank J. Lin Haley Pak Jackson S. Turner Lucas J. Adams Tom Liu Daved H. Fremont Ali H. Ellebedy Brian J. Laidlaw CD62L expression marks a functionally distinct subset of memory B cells Cell Reports CP: Immunology |
| title | CD62L expression marks a functionally distinct subset of memory B cells |
| title_full | CD62L expression marks a functionally distinct subset of memory B cells |
| title_fullStr | CD62L expression marks a functionally distinct subset of memory B cells |
| title_full_unstemmed | CD62L expression marks a functionally distinct subset of memory B cells |
| title_short | CD62L expression marks a functionally distinct subset of memory B cells |
| title_sort | cd62l expression marks a functionally distinct subset of memory b cells |
| topic | CP: Immunology |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723015541 |
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