Cartilage Micrografts as a Novel Non-Invasive and Non-Arthroscopic Autograft Procedure for Knee Chondropathy: Three-Year Follow-Up Study
(1) Background: Focal chondral defects of the knee can significantly impair patient quality of life. Although different options are available, they are still not conclusive and have several limitations. The aim of this study was to evaluate the role of autologous cartilage micrografts in the treatme...
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| Format: | Article |
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MDPI AG
2021-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/2/322 |
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| author | Marco Marcarelli Marcello Zappia Lorenzo Rissolio Chiara Baroni Carlo Astarita Letizia Trovato Antonio Graziano |
| author_facet | Marco Marcarelli Marcello Zappia Lorenzo Rissolio Chiara Baroni Carlo Astarita Letizia Trovato Antonio Graziano |
| author_sort | Marco Marcarelli |
| collection | DOAJ |
| description | (1) Background: Focal chondral defects of the knee can significantly impair patient quality of life. Although different options are available, they are still not conclusive and have several limitations. The aim of this study was to evaluate the role of autologous cartilage micrografts in the treatment of knee chondropathy. (2) Methods: Eight patients affected by knee chondropathy were evaluated before and after 6 months and 3 years following autologous cartilage micrografts by magnetic resonance imaging (MRI) for cartilage measurement and clinical assessment. (3) Results: All patients recovered daily activities, reporting pain reduction without the need for analgesic therapy; Oxford Knee Score (OKS) was 28.4 ± 6 and 40.8 ± 6.2 and visual analogue scale (VAS) was 5.5 ± 1.6 and 1.8 ± 0.7 before and after 6 months following treatment, respectively. Both scores remained stable after 3 years. Lastly, a significant improvement of the cartilage thickness was observed using MRI after 3 years. (4) Conclusions: Autologous cartilage micrografts can promote the formation of new cartilage, and could be a valid approach for the treatment of knee chondropathy. |
| first_indexed | 2024-03-09T04:33:29Z |
| format | Article |
| id | doaj.art-f96997c338b049689e13b46c96509b3a |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T04:33:29Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-f96997c338b049689e13b46c96509b3a2023-12-03T13:32:23ZengMDPI AGJournal of Clinical Medicine2077-03832021-01-0110232210.3390/jcm10020322Cartilage Micrografts as a Novel Non-Invasive and Non-Arthroscopic Autograft Procedure for Knee Chondropathy: Three-Year Follow-Up StudyMarco Marcarelli0Marcello Zappia1Lorenzo Rissolio2Chiara Baroni3Carlo Astarita4Letizia Trovato5Antonio Graziano6Unit of Orthopedics and Traumatology of Chieri and Moncalieri, Santa Croce Hospital, 10024 Turin, ItalyDepartment of Medicine and Health Sciences, University of Molise, 86100 Campobasso, ItalyUnit of Orthopedics and Traumatology of Chieri and Moncalieri, Santa Croce Hospital, 10024 Turin, ItalyUnit of Orthopedics and Traumatology of Chieri and Moncalieri, Santa Croce Hospital, 10024 Turin, ItalyHuman Brain Wave, Corso Galileo Ferraris, 63, 10128 Turin, ItalySbarro Institute for Cancer Research and Molecular Medicine, Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA 19126, USAHuman Brain Wave, Corso Galileo Ferraris, 63, 10128 Turin, Italy(1) Background: Focal chondral defects of the knee can significantly impair patient quality of life. Although different options are available, they are still not conclusive and have several limitations. The aim of this study was to evaluate the role of autologous cartilage micrografts in the treatment of knee chondropathy. (2) Methods: Eight patients affected by knee chondropathy were evaluated before and after 6 months and 3 years following autologous cartilage micrografts by magnetic resonance imaging (MRI) for cartilage measurement and clinical assessment. (3) Results: All patients recovered daily activities, reporting pain reduction without the need for analgesic therapy; Oxford Knee Score (OKS) was 28.4 ± 6 and 40.8 ± 6.2 and visual analogue scale (VAS) was 5.5 ± 1.6 and 1.8 ± 0.7 before and after 6 months following treatment, respectively. Both scores remained stable after 3 years. Lastly, a significant improvement of the cartilage thickness was observed using MRI after 3 years. (4) Conclusions: Autologous cartilage micrografts can promote the formation of new cartilage, and could be a valid approach for the treatment of knee chondropathy.https://www.mdpi.com/2077-0383/10/2/322cartilage micrograftsmedical deviceregenerative medicine |
| spellingShingle | Marco Marcarelli Marcello Zappia Lorenzo Rissolio Chiara Baroni Carlo Astarita Letizia Trovato Antonio Graziano Cartilage Micrografts as a Novel Non-Invasive and Non-Arthroscopic Autograft Procedure for Knee Chondropathy: Three-Year Follow-Up Study Journal of Clinical Medicine cartilage micrografts medical device regenerative medicine |
| title | Cartilage Micrografts as a Novel Non-Invasive and Non-Arthroscopic Autograft Procedure for Knee Chondropathy: Three-Year Follow-Up Study |
| title_full | Cartilage Micrografts as a Novel Non-Invasive and Non-Arthroscopic Autograft Procedure for Knee Chondropathy: Three-Year Follow-Up Study |
| title_fullStr | Cartilage Micrografts as a Novel Non-Invasive and Non-Arthroscopic Autograft Procedure for Knee Chondropathy: Three-Year Follow-Up Study |
| title_full_unstemmed | Cartilage Micrografts as a Novel Non-Invasive and Non-Arthroscopic Autograft Procedure for Knee Chondropathy: Three-Year Follow-Up Study |
| title_short | Cartilage Micrografts as a Novel Non-Invasive and Non-Arthroscopic Autograft Procedure for Knee Chondropathy: Three-Year Follow-Up Study |
| title_sort | cartilage micrografts as a novel non invasive and non arthroscopic autograft procedure for knee chondropathy three year follow up study |
| topic | cartilage micrografts medical device regenerative medicine |
| url | https://www.mdpi.com/2077-0383/10/2/322 |
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