Record‐High Ultrasound‐Sensitive NO Nanogenerators for Cascade Tumor Pyroptosis and Immunotherapy
Abstract Pyroptosis is a pro‐inflammatory cell death that is associated with innate immunity promotion against tumors. Excess nitric oxide (NO)‐triggered nitric stress has potential to induce pyroptosis, but the precise delivery of NO is challenging. Ultrasound (US)‐responsive NO production has domi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-09-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202302278 |
| _version_ | 1797684983494606848 |
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| author | Yuheng Bao Yanni Ge Mengjie Wu Zhengwei Mao Juan Ye Weijun Tong |
| author_facet | Yuheng Bao Yanni Ge Mengjie Wu Zhengwei Mao Juan Ye Weijun Tong |
| author_sort | Yuheng Bao |
| collection | DOAJ |
| description | Abstract Pyroptosis is a pro‐inflammatory cell death that is associated with innate immunity promotion against tumors. Excess nitric oxide (NO)‐triggered nitric stress has potential to induce pyroptosis, but the precise delivery of NO is challenging. Ultrasound (US)‐responsive NO production has dominant priority due to its deep penetration, low side effects, noninvasion, and local activation manner. In this work, US‐sensitive NO donor N‐methyl‐N‐nitrosoaniline (NMA) with thermodynamically favorable structure is selected and loaded into hyaluronic acid (HA)‐modified hollow manganese dioxide nanoparticles (hMnO2 NPs) to fabricate hMnO2@HA@NMA (MHN) nanogenerators (NGs). The obtained NGs have a record‐high NO generation efficiency under US irradiation and can release Mn2+ after targeting the tumor sites. Later on, cascade tumor pyroptosis and cyclic GMP‐AMP synthase‐stimulator of interferon genes (cGAS‐STING)‐based immunotherapy is achieved and tumor growth is effectively inhibited. |
| first_indexed | 2024-03-12T00:37:46Z |
| format | Article |
| id | doaj.art-f9699ce801844ed28a13a25b66f9516a |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-12T00:37:46Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-f9699ce801844ed28a13a25b66f9516a2023-09-15T09:28:59ZengWileyAdvanced Science2198-38442023-09-011026n/an/a10.1002/advs.202302278Record‐High Ultrasound‐Sensitive NO Nanogenerators for Cascade Tumor Pyroptosis and ImmunotherapyYuheng Bao0Yanni Ge1Mengjie Wu2Zhengwei Mao3Juan Ye4Weijun Tong5MOE Key Laboratory of Macromolecular Synthesis and Functionalization Ministry of Education Department of Polymer Science and Engineering Zhejiang University Hangzhou Zhejiang 310027 ChinaEye Center The Second Affiliated Hospital School of Medicine Zhejiang University Zhejiang Provincial Key Laboratory of Ophthalmology Zhejiang Provincial Clinical Research Center for Eye Diseases Zhejiang Provincial Engineering Institute on Eye Diseases Hangzhou Zhejiang 310009 ChinaStomatology Hospital School of Stomatology Zhejiang University School of Medicine Zhejiang Provincial Clinical Research Center for Oral Diseases Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University Hangzhou Zhejiang 310058 ChinaMOE Key Laboratory of Macromolecular Synthesis and Functionalization Ministry of Education Department of Polymer Science and Engineering Zhejiang University Hangzhou Zhejiang 310027 ChinaEye Center The Second Affiliated Hospital School of Medicine Zhejiang University Zhejiang Provincial Key Laboratory of Ophthalmology Zhejiang Provincial Clinical Research Center for Eye Diseases Zhejiang Provincial Engineering Institute on Eye Diseases Hangzhou Zhejiang 310009 ChinaMOE Key Laboratory of Macromolecular Synthesis and Functionalization Ministry of Education Department of Polymer Science and Engineering Zhejiang University Hangzhou Zhejiang 310027 ChinaAbstract Pyroptosis is a pro‐inflammatory cell death that is associated with innate immunity promotion against tumors. Excess nitric oxide (NO)‐triggered nitric stress has potential to induce pyroptosis, but the precise delivery of NO is challenging. Ultrasound (US)‐responsive NO production has dominant priority due to its deep penetration, low side effects, noninvasion, and local activation manner. In this work, US‐sensitive NO donor N‐methyl‐N‐nitrosoaniline (NMA) with thermodynamically favorable structure is selected and loaded into hyaluronic acid (HA)‐modified hollow manganese dioxide nanoparticles (hMnO2 NPs) to fabricate hMnO2@HA@NMA (MHN) nanogenerators (NGs). The obtained NGs have a record‐high NO generation efficiency under US irradiation and can release Mn2+ after targeting the tumor sites. Later on, cascade tumor pyroptosis and cyclic GMP‐AMP synthase‐stimulator of interferon genes (cGAS‐STING)‐based immunotherapy is achieved and tumor growth is effectively inhibited.https://doi.org/10.1002/advs.202302278cascade tumor therapycGAS‐STINGhollow MnO2NO donorpyroptosisultrasound response |
| spellingShingle | Yuheng Bao Yanni Ge Mengjie Wu Zhengwei Mao Juan Ye Weijun Tong Record‐High Ultrasound‐Sensitive NO Nanogenerators for Cascade Tumor Pyroptosis and Immunotherapy Advanced Science cascade tumor therapy cGAS‐STING hollow MnO2 NO donor pyroptosis ultrasound response |
| title | Record‐High Ultrasound‐Sensitive NO Nanogenerators for Cascade Tumor Pyroptosis and Immunotherapy |
| title_full | Record‐High Ultrasound‐Sensitive NO Nanogenerators for Cascade Tumor Pyroptosis and Immunotherapy |
| title_fullStr | Record‐High Ultrasound‐Sensitive NO Nanogenerators for Cascade Tumor Pyroptosis and Immunotherapy |
| title_full_unstemmed | Record‐High Ultrasound‐Sensitive NO Nanogenerators for Cascade Tumor Pyroptosis and Immunotherapy |
| title_short | Record‐High Ultrasound‐Sensitive NO Nanogenerators for Cascade Tumor Pyroptosis and Immunotherapy |
| title_sort | record high ultrasound sensitive no nanogenerators for cascade tumor pyroptosis and immunotherapy |
| topic | cascade tumor therapy cGAS‐STING hollow MnO2 NO donor pyroptosis ultrasound response |
| url | https://doi.org/10.1002/advs.202302278 |
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