Galantamine-Curcumin Hybrids as Dual-Site Binding Acetylcholinesterase Inhibitors

Galantamine-Curcumin Hybrids as Dual-Site Binding Acetylcholinesterase Inhibitors

Galantamine (GAL) and curcumin (CU) are alkaloids used to improve symptomatically neurodegenerative conditions like Alzheimer’s disease (AD). GAL acts mainly as an inhibitor of the enzyme acetylcholinesterase (AChE). CU binds to amyloid-beta (Aβ) oligomers and inhibits the formation of Aβ plaques. H...

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Bibliographic Details
Main Authors: Georgi Stavrakov, Irena Philipova, Atanas Lukarski, Mariyana Atanasova, Dimitrina Zheleva, Zvetanka D. Zhivkova, Stefan Ivanov, Teodora Atanasova, Spiro Konstantinov, Irini Doytchinova
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Molecules
Subjects:
virtual screening
molecular docking
neurotoxicity
ADME
BBB permeability
Online Access:https://www.mdpi.com/1420-3049/25/15/3341

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