Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference

Morphogenesis involves interactions of asymmetric cell populations to form complex multicellular patterns and structures comprised of distinct cell types. However, current methods to model morphogenic events lack control over cell-type co-emergence and offer little capability to selectively perturb...

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Détails bibliographiques
Auteurs principaux: Ashley RG Libby, David A Joy, Po-Lin So, Mohammad A Mandegar, Jonathon M Muncie, Federico N Mendoza-Camacho, Valerie M Weaver, Bruce R Conklin, Todd C McDevitt
Format: Article
Langue:English
Publié: eLife Sciences Publications Ltd 2018-10-01
Collection:eLife
Sujets:
Accès en ligne:https://elifesciences.org/articles/36045