Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference
Morphogenesis involves interactions of asymmetric cell populations to form complex multicellular patterns and structures comprised of distinct cell types. However, current methods to model morphogenic events lack control over cell-type co-emergence and offer little capability to selectively perturb...
Main Authors: | Ashley RG Libby, David A Joy, Po-Lin So, Mohammad A Mandegar, Jonathon M Muncie, Federico N Mendoza-Camacho, Valerie M Weaver, Bruce R Conklin, Todd C McDevitt |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2018-10-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/36045 |
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