Recent Approaches in Magnetic Nanoparticle-Based Biosensors of miRNA Detection
In recent years, magnetic nanoparticles (MNPs) have been widely used in many fields due to their advantageous properties, such as biocompatibility, easy modifiability, and high chemical stability. One of these areas is the detection of cancer. It is essential to use existing biomarkers, such as micr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Magnetochemistry |
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| Online Access: | https://www.mdpi.com/2312-7481/9/1/23 |
| _version_ | 1797439447589978112 |
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| author | Simge Balaban Hanoglu Duygu Harmanci Nursima Ucar Serap Evran Suna Timur |
| author_facet | Simge Balaban Hanoglu Duygu Harmanci Nursima Ucar Serap Evran Suna Timur |
| author_sort | Simge Balaban Hanoglu |
| collection | DOAJ |
| description | In recent years, magnetic nanoparticles (MNPs) have been widely used in many fields due to their advantageous properties, such as biocompatibility, easy modifiability, and high chemical stability. One of these areas is the detection of cancer. It is essential to use existing biomarkers, such as microRNAs (miRNAs), for the early diagnosis of this disease. miRNAs are challenging to distinguish and detect in biological samples because they are small, circulating molecules. It is necessary to use more sensitive and feature-rich systems. Thanks to their large surface areas and magnetic moments, MNPs allow easy separation of miRNA at low concentrations from complex samples (urine and blood) and rapid and specific detection in biosensing systems. Here, we discussed the synthesis and characterization methods of MNPs, their stabilization, and MNP-based biosensors in terms of miRNA detection. We considered the challenges and prospects of these biosensor systems in evaluating the development stages, sensitivity, and selectivity. |
| first_indexed | 2024-03-09T11:53:01Z |
| format | Article |
| id | doaj.art-f96a4b1123eb43ab9c639996f8d7b6ab |
| institution | Directory Open Access Journal |
| issn | 2312-7481 |
| language | English |
| last_indexed | 2024-03-09T11:53:01Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Magnetochemistry |
| spelling | doaj.art-f96a4b1123eb43ab9c639996f8d7b6ab2023-11-30T23:12:57ZengMDPI AGMagnetochemistry2312-74812023-01-01912310.3390/magnetochemistry9010023Recent Approaches in Magnetic Nanoparticle-Based Biosensors of miRNA DetectionSimge Balaban Hanoglu0Duygu Harmanci1Nursima Ucar2Serap Evran3Suna Timur4Department of Biochemistry, Faculty of Science, Ege University, Bornova, Izmir 35100, TurkeyCentral Research Test and Analysis Laboratory, Application and Research Center, Ege University, Bornova, Izmir 35100, TurkeyDepartment of Biochemistry, Faculty of Science, Ege University, Bornova, Izmir 35100, TurkeyDepartment of Biochemistry, Faculty of Science, Ege University, Bornova, Izmir 35100, TurkeyDepartment of Biochemistry, Faculty of Science, Ege University, Bornova, Izmir 35100, TurkeyIn recent years, magnetic nanoparticles (MNPs) have been widely used in many fields due to their advantageous properties, such as biocompatibility, easy modifiability, and high chemical stability. One of these areas is the detection of cancer. It is essential to use existing biomarkers, such as microRNAs (miRNAs), for the early diagnosis of this disease. miRNAs are challenging to distinguish and detect in biological samples because they are small, circulating molecules. It is necessary to use more sensitive and feature-rich systems. Thanks to their large surface areas and magnetic moments, MNPs allow easy separation of miRNA at low concentrations from complex samples (urine and blood) and rapid and specific detection in biosensing systems. Here, we discussed the synthesis and characterization methods of MNPs, their stabilization, and MNP-based biosensors in terms of miRNA detection. We considered the challenges and prospects of these biosensor systems in evaluating the development stages, sensitivity, and selectivity.https://www.mdpi.com/2312-7481/9/1/23magnetic nanoparticles (MNPs)magnetic sensingbiosensorscancer biomarkermicroRNA (miRNA) |
| spellingShingle | Simge Balaban Hanoglu Duygu Harmanci Nursima Ucar Serap Evran Suna Timur Recent Approaches in Magnetic Nanoparticle-Based Biosensors of miRNA Detection Magnetochemistry magnetic nanoparticles (MNPs) magnetic sensing biosensors cancer biomarker microRNA (miRNA) |
| title | Recent Approaches in Magnetic Nanoparticle-Based Biosensors of miRNA Detection |
| title_full | Recent Approaches in Magnetic Nanoparticle-Based Biosensors of miRNA Detection |
| title_fullStr | Recent Approaches in Magnetic Nanoparticle-Based Biosensors of miRNA Detection |
| title_full_unstemmed | Recent Approaches in Magnetic Nanoparticle-Based Biosensors of miRNA Detection |
| title_short | Recent Approaches in Magnetic Nanoparticle-Based Biosensors of miRNA Detection |
| title_sort | recent approaches in magnetic nanoparticle based biosensors of mirna detection |
| topic | magnetic nanoparticles (MNPs) magnetic sensing biosensors cancer biomarker microRNA (miRNA) |
| url | https://www.mdpi.com/2312-7481/9/1/23 |
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