The role of the microenvironment in tumor growth and spreading
Introduction. The tumor microenvironment (TME) consisting of non-tumor cells and other components plays a crucial role in cancer development by promoting uncontrolled tumor growth.Aim: to detail all the components in TME and their contribution to carcinogenesis by analyzing available publications.Re...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2024-03-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/1955 |
| _version_ | 1826567127092428800 |
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| author | V. О. Bitsadze Е. V. Slukhanchuk А. G. Solopova J. Kh. Khizroeva F. E. Yakubova Е. А. Orudzhova N. D. Degtyareva Е. S. Egorova N. А. Makatsariya N. V. Samburova V. N. Serov L. А. Ashrafyan Z. D. Aslanova А. V. Lazarchuk Е. S. Kudryavtseva А. Е. Solopova D. L. Kapanadze J.-C. Gris I. Elalamy С. Ay А. D. Makatsariya |
| author_facet | V. О. Bitsadze Е. V. Slukhanchuk А. G. Solopova J. Kh. Khizroeva F. E. Yakubova Е. А. Orudzhova N. D. Degtyareva Е. S. Egorova N. А. Makatsariya N. V. Samburova V. N. Serov L. А. Ashrafyan Z. D. Aslanova А. V. Lazarchuk Е. S. Kudryavtseva А. Е. Solopova D. L. Kapanadze J.-C. Gris I. Elalamy С. Ay А. D. Makatsariya |
| author_sort | V. О. Bitsadze |
| collection | DOAJ |
| description | Introduction. The tumor microenvironment (TME) consisting of non-tumor cells and other components plays a crucial role in cancer development by promoting uncontrolled tumor growth.Aim: to detail all the components in TME and their contribution to carcinogenesis by analyzing available publications.Results. Currently, TME study is of great interest in the medical field. Its crucial role in the tumor initiation, progression, and spreading is emphasized. Several constituents have been identified in TME including cancer-associated fibroblasts, neutrophils, adipocytes, tumor vasculature, lymphocytes, extracellular matrix, dendritic cells, neutrophil extracellular traps, etc. Thromboinflammatory reactions are also considered an important TME element.Conclusion. TME constituents can serve as new targets for both diagnostics and antitumor therapy. |
| first_indexed | 2025-03-14T11:02:36Z |
| format | Article |
| id | doaj.art-f96c341a1d404269a77bf296a1e8a87d |
| institution | Directory Open Access Journal |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| last_indexed | 2025-03-14T11:02:36Z |
| publishDate | 2024-03-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj.art-f96c341a1d404269a77bf296a1e8a87d2025-03-02T10:43:09ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942024-03-011819611110.17749/2313-7347/ob.gyn.rep.2024.489864The role of the microenvironment in tumor growth and spreadingV. О. Bitsadze0Е. V. Slukhanchuk1А. G. Solopova2J. Kh. Khizroeva3F. E. Yakubova4Е. А. Orudzhova5N. D. Degtyareva6Е. S. Egorova7N. А. Makatsariya8N. V. Samburova9V. N. Serov10L. А. Ashrafyan11Z. D. Aslanova12А. V. Lazarchuk13Е. S. Kudryavtseva14А. Е. Solopova15D. L. Kapanadze16J.-C. Gris17I. Elalamy18С. Ay19А. D. Makatsariya20Sechenov UniversitySechenov UniversitySechenov UniversitySechenov UniversitySechenov UniversityMaternity Hospital No. 1 – Branch of Vorokhobov City Clinical Hospital No. 67 Moscow City Healthcare DepartmentSechenov UniversitySechenov UniversitySechenov UniversitySechenov UniversityKulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Health Ministry of Russian FederationKulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Health Ministry of Russian FederationSechenov UniversitySechenov UniversitySechenov UniversitySechenov University; Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Health Ministry of Russian FederationCenter for Pathology of Pregnancy and HemostasisSechenov University; Montpellier UniversitySechenov University; Medicine Sorbonne University; Hospital TenonUniversity of ViennaSechenov UniversityIntroduction. The tumor microenvironment (TME) consisting of non-tumor cells and other components plays a crucial role in cancer development by promoting uncontrolled tumor growth.Aim: to detail all the components in TME and their contribution to carcinogenesis by analyzing available publications.Results. Currently, TME study is of great interest in the medical field. Its crucial role in the tumor initiation, progression, and spreading is emphasized. Several constituents have been identified in TME including cancer-associated fibroblasts, neutrophils, adipocytes, tumor vasculature, lymphocytes, extracellular matrix, dendritic cells, neutrophil extracellular traps, etc. Thromboinflammatory reactions are also considered an important TME element.Conclusion. TME constituents can serve as new targets for both diagnostics and antitumor therapy.https://www.gynecology.su/jour/article/view/1955tumor microenvironmenttmetumor progressiontumor growthcancermetastasis |
| spellingShingle | V. О. Bitsadze Е. V. Slukhanchuk А. G. Solopova J. Kh. Khizroeva F. E. Yakubova Е. А. Orudzhova N. D. Degtyareva Е. S. Egorova N. А. Makatsariya N. V. Samburova V. N. Serov L. А. Ashrafyan Z. D. Aslanova А. V. Lazarchuk Е. S. Kudryavtseva А. Е. Solopova D. L. Kapanadze J.-C. Gris I. Elalamy С. Ay А. D. Makatsariya The role of the microenvironment in tumor growth and spreading Акушерство, гинекология и репродукция tumor microenvironment tme tumor progression tumor growth cancer metastasis |
| title | The role of the microenvironment in tumor growth and spreading |
| title_full | The role of the microenvironment in tumor growth and spreading |
| title_fullStr | The role of the microenvironment in tumor growth and spreading |
| title_full_unstemmed | The role of the microenvironment in tumor growth and spreading |
| title_short | The role of the microenvironment in tumor growth and spreading |
| title_sort | role of the microenvironment in tumor growth and spreading |
| topic | tumor microenvironment tme tumor progression tumor growth cancer metastasis |
| url | https://www.gynecology.su/jour/article/view/1955 |
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