Update on Obesity in Psoriasis Patients
Psoriasis is a chronic inflammatory skin condition, with genetic, epigenetic, environmental, and lifestyle factors contributing to its onset and recurrence. Severe psoriasis has a great impact on quality of life, which is similar to that of insulin-dependent diabetes, depression, and ischemic heart...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/10/1947 |
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| author | Dan Vata Bogdan Marian Tarcau Ioana Adriana Popescu Ioana Alina Halip Adriana Ionela Patrascu Dragos-Florin Gheuca Solovastru Madalina Mocanu Petronela Cristina Chiriac Laura Gheuca Solovastru |
| author_facet | Dan Vata Bogdan Marian Tarcau Ioana Adriana Popescu Ioana Alina Halip Adriana Ionela Patrascu Dragos-Florin Gheuca Solovastru Madalina Mocanu Petronela Cristina Chiriac Laura Gheuca Solovastru |
| author_sort | Dan Vata |
| collection | DOAJ |
| description | Psoriasis is a chronic inflammatory skin condition, with genetic, epigenetic, environmental, and lifestyle factors contributing to its onset and recurrence. Severe psoriasis has a great impact on quality of life, which is similar to that of insulin-dependent diabetes, depression, and ischemic heart disease, but with a lower mortality. There is an overlap between the rising incidences of autoimmune diseases and obesity. In recent years, research has shown that there is an association between psoriasis and obesity. Psoriasis is linked to obesity in a two-way manner, as each can precipitate the development of the other. Several adipose tissue-secreted adipokines were shown to be elevated in obese psoriasis patients, exhibiting similar mechanisms of action to those underlying the pathogenesis of psoriasis. Excess body weight can influence not only the treatment response in psoriasis, but also the adverse events, leading to decreased patient compliance. Specific human microbiome patterns have been identified for obesity and psoriasis and could represent a future therapeutic target in selected individuals. |
| first_indexed | 2024-03-10T21:07:26Z |
| format | Article |
| id | doaj.art-f96d136f55a84ae1b005eeaea9683a31 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T21:07:26Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-f96d136f55a84ae1b005eeaea9683a312023-11-19T17:05:12ZengMDPI AGLife2075-17292023-09-011310194710.3390/life13101947Update on Obesity in Psoriasis PatientsDan Vata0Bogdan Marian Tarcau1Ioana Adriana Popescu2Ioana Alina Halip3Adriana Ionela Patrascu4Dragos-Florin Gheuca Solovastru5Madalina Mocanu6Petronela Cristina Chiriac7Laura Gheuca Solovastru8Department of Dermatology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Dermatology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Dermatology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Dermatology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Dermatology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania“Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Dermatology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania“St. Spiridon” County Emergency Clinical Hospital, 700111 Iasi, RomaniaDepartment of Dermatology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaPsoriasis is a chronic inflammatory skin condition, with genetic, epigenetic, environmental, and lifestyle factors contributing to its onset and recurrence. Severe psoriasis has a great impact on quality of life, which is similar to that of insulin-dependent diabetes, depression, and ischemic heart disease, but with a lower mortality. There is an overlap between the rising incidences of autoimmune diseases and obesity. In recent years, research has shown that there is an association between psoriasis and obesity. Psoriasis is linked to obesity in a two-way manner, as each can precipitate the development of the other. Several adipose tissue-secreted adipokines were shown to be elevated in obese psoriasis patients, exhibiting similar mechanisms of action to those underlying the pathogenesis of psoriasis. Excess body weight can influence not only the treatment response in psoriasis, but also the adverse events, leading to decreased patient compliance. Specific human microbiome patterns have been identified for obesity and psoriasis and could represent a future therapeutic target in selected individuals.https://www.mdpi.com/2075-1729/13/10/1947psoriasisobesityadipokinesautoimmunemicrobiome |
| spellingShingle | Dan Vata Bogdan Marian Tarcau Ioana Adriana Popescu Ioana Alina Halip Adriana Ionela Patrascu Dragos-Florin Gheuca Solovastru Madalina Mocanu Petronela Cristina Chiriac Laura Gheuca Solovastru Update on Obesity in Psoriasis Patients Life psoriasis obesity adipokines autoimmune microbiome |
| title | Update on Obesity in Psoriasis Patients |
| title_full | Update on Obesity in Psoriasis Patients |
| title_fullStr | Update on Obesity in Psoriasis Patients |
| title_full_unstemmed | Update on Obesity in Psoriasis Patients |
| title_short | Update on Obesity in Psoriasis Patients |
| title_sort | update on obesity in psoriasis patients |
| topic | psoriasis obesity adipokines autoimmune microbiome |
| url | https://www.mdpi.com/2075-1729/13/10/1947 |
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