Association of hypertriglyceridemic‐waist phenotype with liver enzymes and cardiometabolic risk factors in adolescents: the CASPIAN‐III study
Objective: This study aims to investigate the role of metabolic syndrome (MetS) and the hypertriglyceridemic‐waist (HW) phenotype in determining cardiometabolic risk factors and elevated liver enzymes in a national sample of Iranian pediatric population. Method: This nationwide study was conducted i...
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| Format: | Article |
| Language: | Portuguese |
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Brazilian Society of Pediatrics
2016-09-01
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| Series: | Jornal de Pediatria (Versão em Português) |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2255553616300763 |
| _version_ | 1811193403967275008 |
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| author | Roya Kelishadi Fahimeh Jamshidi Mostafa Qorbani Mohammad Esmaeil Motlagh Ramin Heshmat Gelayol Ardalan Silva Hovsepian |
| author_facet | Roya Kelishadi Fahimeh Jamshidi Mostafa Qorbani Mohammad Esmaeil Motlagh Ramin Heshmat Gelayol Ardalan Silva Hovsepian |
| author_sort | Roya Kelishadi |
| collection | DOAJ |
| description | Objective: This study aims to investigate the role of metabolic syndrome (MetS) and the hypertriglyceridemic‐waist (HW) phenotype in determining cardiometabolic risk factors and elevated liver enzymes in a national sample of Iranian pediatric population.
Method: This nationwide study was conducted in the framework of the third survey of a surveillance program. Students, aged 10‐18 years, were recruited from 27 provinces in Iran. The prevalence of cardiometabolic risk factors was compared in students with and without HW and MetS. The association of HW with different cardiometabolic risk factors was determined.
Results: The mean age of studied population was 14.73 ± 2.41 years. Prevalence of HW and MetS was 3.3% and 4%, respectively. Sixty‐nine (71.1%) participants with HW had MetS. The prevalence of obesity, elevated systolic blood pressure, hypercholesterolemia, and elevated ALT was significantly higher in subjects with HW phenotype and MetS than in their peers (p < 0.05). A significant association was observed between HW and elevated levels of cholesterol and ALT, as well as between obesity and low HDL‐C (p < 0.05).
Conclusions: The current findings serve as complementary evidence to previous studies, which have been mainly conducted among adults, suggesting that the HW phenotype is associated with cardiometabolic risk factors, especially with elevated cholesterol and ALT. The authors propose that, in primary care settings and in large epidemiological studies, the measurement of all MetS components can be replaced by studying HW as a screening tool for identifying children at high risk for cardiometabolic disorders. |
| first_indexed | 2024-04-12T00:08:53Z |
| format | Article |
| id | doaj.art-f96ff3cc59404173b67099df085122d3 |
| institution | Directory Open Access Journal |
| issn | 2255-5536 |
| language | Portuguese |
| last_indexed | 2024-04-12T00:08:53Z |
| publishDate | 2016-09-01 |
| publisher | Brazilian Society of Pediatrics |
| record_format | Article |
| series | Jornal de Pediatria (Versão em Português) |
| spelling | doaj.art-f96ff3cc59404173b67099df085122d32022-12-22T03:56:02ZporBrazilian Society of PediatricsJornal de Pediatria (Versão em Português)2255-55362016-09-0192551252010.1016/j.jpedp.2016.06.014Association of hypertriglyceridemic‐waist phenotype with liver enzymes and cardiometabolic risk factors in adolescents: the CASPIAN‐III studyRoya Kelishadi0Fahimeh Jamshidi1Mostafa Qorbani2Mohammad Esmaeil Motlagh3Ramin Heshmat4Gelayol Ardalan5Silva Hovsepian6Isfahan University of Medical Sciences, Research Institute for Primordial Prevention of Non‐communicable Disease, Child Growth and Development Research Center, Isfahan, IrãIsfahan University of Medical Sciences, Research Institute for Primordial Prevention of Non‐communicable Disease, Child Growth and Development Research Center, Isfahan, IrãAlborz University of Medical Sciences, Department of Community Medicine, Karaj, IrãAhvaz Jundishapur University of Medical Sciences, Faculty of Medicine, Department of Pediatrics, Ahvaz, IrãTehran University of Medical Sciences, Endocrinology and Metabolism Population Sciences Institute, Chronic Diseases Research Center, Teerã, IrãIsfahan University of Medical Sciences, Research Institute for Primordial Prevention of Non‐communicable Disease, Child Growth and Development Research Center, Isfahan, IrãIsfahan University of Medical Sciences, Research Institute for Primordial Prevention of Non‐communicable Disease, Child Growth and Development Research Center, Isfahan, IrãObjective: This study aims to investigate the role of metabolic syndrome (MetS) and the hypertriglyceridemic‐waist (HW) phenotype in determining cardiometabolic risk factors and elevated liver enzymes in a national sample of Iranian pediatric population. Method: This nationwide study was conducted in the framework of the third survey of a surveillance program. Students, aged 10‐18 years, were recruited from 27 provinces in Iran. The prevalence of cardiometabolic risk factors was compared in students with and without HW and MetS. The association of HW with different cardiometabolic risk factors was determined. Results: The mean age of studied population was 14.73 ± 2.41 years. Prevalence of HW and MetS was 3.3% and 4%, respectively. Sixty‐nine (71.1%) participants with HW had MetS. The prevalence of obesity, elevated systolic blood pressure, hypercholesterolemia, and elevated ALT was significantly higher in subjects with HW phenotype and MetS than in their peers (p < 0.05). A significant association was observed between HW and elevated levels of cholesterol and ALT, as well as between obesity and low HDL‐C (p < 0.05). Conclusions: The current findings serve as complementary evidence to previous studies, which have been mainly conducted among adults, suggesting that the HW phenotype is associated with cardiometabolic risk factors, especially with elevated cholesterol and ALT. The authors propose that, in primary care settings and in large epidemiological studies, the measurement of all MetS components can be replaced by studying HW as a screening tool for identifying children at high risk for cardiometabolic disorders.http://www.sciencedirect.com/science/article/pii/S2255553616300763Hypertriglyceridemic waistMetabolic syndromeChildren and adolescentLipid profileLiver function test |
| spellingShingle | Roya Kelishadi Fahimeh Jamshidi Mostafa Qorbani Mohammad Esmaeil Motlagh Ramin Heshmat Gelayol Ardalan Silva Hovsepian Association of hypertriglyceridemic‐waist phenotype with liver enzymes and cardiometabolic risk factors in adolescents: the CASPIAN‐III study Jornal de Pediatria (Versão em Português) Hypertriglyceridemic waist Metabolic syndrome Children and adolescent Lipid profile Liver function test |
| title | Association of hypertriglyceridemic‐waist phenotype with liver enzymes and cardiometabolic risk factors in adolescents: the CASPIAN‐III study |
| title_full | Association of hypertriglyceridemic‐waist phenotype with liver enzymes and cardiometabolic risk factors in adolescents: the CASPIAN‐III study |
| title_fullStr | Association of hypertriglyceridemic‐waist phenotype with liver enzymes and cardiometabolic risk factors in adolescents: the CASPIAN‐III study |
| title_full_unstemmed | Association of hypertriglyceridemic‐waist phenotype with liver enzymes and cardiometabolic risk factors in adolescents: the CASPIAN‐III study |
| title_short | Association of hypertriglyceridemic‐waist phenotype with liver enzymes and cardiometabolic risk factors in adolescents: the CASPIAN‐III study |
| title_sort | association of hypertriglyceridemic waist phenotype with liver enzymes and cardiometabolic risk factors in adolescents the caspian iii study |
| topic | Hypertriglyceridemic waist Metabolic syndrome Children and adolescent Lipid profile Liver function test |
| url | http://www.sciencedirect.com/science/article/pii/S2255553616300763 |
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