The translational potential of the lung microbiome as a biomarker and a therapeutic target for chronic obstructive pulmonary disease
Abstract Chronic obstructive pulmonary disease (COPD) is a major chronic lung disease with a leading global morbidity and mortality. Emerging evidence suggests that the lung microbiome, the collection of the microorganisms in the lung, plays a crucial role in COPD pathogenesis. The lung microbiome a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2023-10-01
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| Series: | Interdisciplinary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/INMD.20230023 |
| _version_ | 1797644524712886272 |
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| author | Lei Yang Naijian Li Xinzhu Yi Zhang Wang |
| author_facet | Lei Yang Naijian Li Xinzhu Yi Zhang Wang |
| author_sort | Lei Yang |
| collection | DOAJ |
| description | Abstract Chronic obstructive pulmonary disease (COPD) is a major chronic lung disease with a leading global morbidity and mortality. Emerging evidence suggests that the lung microbiome, the collection of the microorganisms in the lung, plays a crucial role in COPD pathogenesis. The lung microbiome alters in COPD during the acute exacerbations, associates with clinical phenotypes and inflammatory endotypes, and predicts treatment response, lung function decline and mortality, suggesting it could be a potential biomarker for COPD phenotyping, prognosis and personalized therapies. The lung microbiome produces metabolites that interact with host immunity and contribute to COPD pathogenesis, implying that it could be a possible novel target for therapeutic intervention. Despite these potentials, critical gaps exist for translational application of the lung microbiome in COPD clinical practice, starting with the lack of approaches in precisely measuring and manipulating specific members of the lung microbiome, highlighting the need for future collaborative efforts from bench to bedsides. In this perspective, we review existing knowledge and progress on the understanding of the lung microbiome as a possible COPD biomarker or a therapeutic target. We discuss current challenges and share our views on future directions toward fully realize the potential in translational application of the lung microbiome in the promise of COPD precision medicine. |
| first_indexed | 2024-03-11T14:31:46Z |
| format | Article |
| id | doaj.art-f971fcf2d78549dcbaf3669a420e36ad |
| institution | Directory Open Access Journal |
| issn | 2832-6245 |
| language | English |
| last_indexed | 2024-03-11T14:31:46Z |
| publishDate | 2023-10-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Interdisciplinary Medicine |
| spelling | doaj.art-f971fcf2d78549dcbaf3669a420e36ad2023-10-31T08:13:22ZengWiley-VCHInterdisciplinary Medicine2832-62452023-10-0114n/an/a10.1002/INMD.20230023The translational potential of the lung microbiome as a biomarker and a therapeutic target for chronic obstructive pulmonary diseaseLei Yang0Naijian Li1Xinzhu Yi2Zhang Wang3Biomedical Research Center Institute of Ecological Sciences School of Life Sciences South China Normal University Guangzhou Guangdong ChinaDepartment of Allergy and Clinical Immunology State Key Laboratory of Respiratory Disease National Center for Respiratory Medicine Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong ChinaBiomedical Research Center Institute of Ecological Sciences School of Life Sciences South China Normal University Guangzhou Guangdong ChinaBiomedical Research Center Institute of Ecological Sciences School of Life Sciences South China Normal University Guangzhou Guangdong ChinaAbstract Chronic obstructive pulmonary disease (COPD) is a major chronic lung disease with a leading global morbidity and mortality. Emerging evidence suggests that the lung microbiome, the collection of the microorganisms in the lung, plays a crucial role in COPD pathogenesis. The lung microbiome alters in COPD during the acute exacerbations, associates with clinical phenotypes and inflammatory endotypes, and predicts treatment response, lung function decline and mortality, suggesting it could be a potential biomarker for COPD phenotyping, prognosis and personalized therapies. The lung microbiome produces metabolites that interact with host immunity and contribute to COPD pathogenesis, implying that it could be a possible novel target for therapeutic intervention. Despite these potentials, critical gaps exist for translational application of the lung microbiome in COPD clinical practice, starting with the lack of approaches in precisely measuring and manipulating specific members of the lung microbiome, highlighting the need for future collaborative efforts from bench to bedsides. In this perspective, we review existing knowledge and progress on the understanding of the lung microbiome as a possible COPD biomarker or a therapeutic target. We discuss current challenges and share our views on future directions toward fully realize the potential in translational application of the lung microbiome in the promise of COPD precision medicine.https://doi.org/10.1002/INMD.20230023biomarkerCOPDlung microbiomeprecision medicinetherapeutic target |
| spellingShingle | Lei Yang Naijian Li Xinzhu Yi Zhang Wang The translational potential of the lung microbiome as a biomarker and a therapeutic target for chronic obstructive pulmonary disease Interdisciplinary Medicine biomarker COPD lung microbiome precision medicine therapeutic target |
| title | The translational potential of the lung microbiome as a biomarker and a therapeutic target for chronic obstructive pulmonary disease |
| title_full | The translational potential of the lung microbiome as a biomarker and a therapeutic target for chronic obstructive pulmonary disease |
| title_fullStr | The translational potential of the lung microbiome as a biomarker and a therapeutic target for chronic obstructive pulmonary disease |
| title_full_unstemmed | The translational potential of the lung microbiome as a biomarker and a therapeutic target for chronic obstructive pulmonary disease |
| title_short | The translational potential of the lung microbiome as a biomarker and a therapeutic target for chronic obstructive pulmonary disease |
| title_sort | translational potential of the lung microbiome as a biomarker and a therapeutic target for chronic obstructive pulmonary disease |
| topic | biomarker COPD lung microbiome precision medicine therapeutic target |
| url | https://doi.org/10.1002/INMD.20230023 |
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