Should doses exceeding 0.2 mg/kg of oral meloxicam be given to reduce surgical recovery time in rabbits and should twice daily administration be considered?
PICO question In reducing surgical recovery time in rabbits (Oryctolagus cuniculus), should doses exceeding 0.2 mg/kg of oral meloxicam be given and is twice daily administration more effective than a single daily dose? Clinical bottom line Category of research question Treatment...
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| Format: | Article |
| Language: | English |
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RCVS Knowledge
2021-07-01
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| Series: | Veterinary Evidence |
| Subjects: | |
| Online Access: | https://veterinaryevidence.org/index.php/ve/article/view/372 |
| _version_ | 1818739779663036416 |
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| author | Eleanor Best |
| author_facet | Eleanor Best |
| author_sort | Eleanor Best |
| collection | DOAJ |
| description | PICO question
In reducing surgical recovery time in rabbits (Oryctolagus cuniculus), should doses exceeding 0.2 mg/kg of oral meloxicam be given and is twice daily administration more effective than a single daily dose?
Clinical bottom line
Category of research question
Treatment
The number and type of study designs reviewed
Nine papers were critically reviewed, yet no studies were found to directly investigate the effects of twice daily dosing with meloxicam postoperatively in rabbits. There were five descriptive, non-comparative case series; two nonblinded parallel group randomised control trials; one blinded, placebo-controlled parallel group randomised trial and one prospective, randomised crossover trial
Strength of evidence
Weak
Outcomes reported
The current recommended oral dose of meloxicam in rabbits of 0.2–0.3 mg/kg once a day was consistently described as inadequate for postoperative analgesia following surgery (Delk et al., 2014). Instead, higher doses of 1–1.5 mg/kg were required to reach a similar peak plasma concentration as found to be clinically effective in other species, such as canines, and provide a better degree of analgesia in rabbits (Montoya et al., 2004; and Delk et al., 2014). Although no studies were found evaluating twice daily administration of meloxicam, the available evidence suggests a dose exceeding 0.2–0.3 mg/kg daily is required for adequate postoperative analgesia in rabbits. Whether this increased dose could be given twice daily should be investigated, providing scope for future research
Conclusion
Further studies are required to directly assess the benefits of twice daily oral meloxicam. However, it is possible that a dose exceeding 0.2–0.3 mg/kg is required and therefore higher doses should be considered in these studies
How to apply this evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care. |
| first_indexed | 2024-12-18T01:30:14Z |
| format | Article |
| id | doaj.art-f972ec2045374770a25c89d3c2b12ce9 |
| institution | Directory Open Access Journal |
| issn | 2396-9776 |
| language | English |
| last_indexed | 2024-12-18T01:30:14Z |
| publishDate | 2021-07-01 |
| publisher | RCVS Knowledge |
| record_format | Article |
| series | Veterinary Evidence |
| spelling | doaj.art-f972ec2045374770a25c89d3c2b12ce92022-12-21T21:25:37ZengRCVS KnowledgeVeterinary Evidence2396-97762021-07-016310.18849/ve.v6i3.372372Should doses exceeding 0.2 mg/kg of oral meloxicam be given to reduce surgical recovery time in rabbits and should twice daily administration be considered?Eleanor Best0University of Bristol Veterinary SchoolPICO question In reducing surgical recovery time in rabbits (Oryctolagus cuniculus), should doses exceeding 0.2 mg/kg of oral meloxicam be given and is twice daily administration more effective than a single daily dose? Clinical bottom line Category of research question Treatment The number and type of study designs reviewed Nine papers were critically reviewed, yet no studies were found to directly investigate the effects of twice daily dosing with meloxicam postoperatively in rabbits. There were five descriptive, non-comparative case series; two nonblinded parallel group randomised control trials; one blinded, placebo-controlled parallel group randomised trial and one prospective, randomised crossover trial Strength of evidence Weak Outcomes reported The current recommended oral dose of meloxicam in rabbits of 0.2–0.3 mg/kg once a day was consistently described as inadequate for postoperative analgesia following surgery (Delk et al., 2014). Instead, higher doses of 1–1.5 mg/kg were required to reach a similar peak plasma concentration as found to be clinically effective in other species, such as canines, and provide a better degree of analgesia in rabbits (Montoya et al., 2004; and Delk et al., 2014). Although no studies were found evaluating twice daily administration of meloxicam, the available evidence suggests a dose exceeding 0.2–0.3 mg/kg daily is required for adequate postoperative analgesia in rabbits. Whether this increased dose could be given twice daily should be investigated, providing scope for future research Conclusion Further studies are required to directly assess the benefits of twice daily oral meloxicam. However, it is possible that a dose exceeding 0.2–0.3 mg/kg is required and therefore higher doses should be considered in these studies How to apply this evidence in practice The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources. Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.https://veterinaryevidence.org/index.php/ve/article/view/372postoperative analgesiaoral meloxicamrabbit analgesiadaily meloxicam administrationpostsurgical managementmeloxicamrabbitsoryctolagus cuniculus |
| spellingShingle | Eleanor Best Should doses exceeding 0.2 mg/kg of oral meloxicam be given to reduce surgical recovery time in rabbits and should twice daily administration be considered? Veterinary Evidence postoperative analgesia oral meloxicam rabbit analgesia daily meloxicam administration postsurgical management meloxicam rabbits oryctolagus cuniculus |
| title | Should doses exceeding 0.2 mg/kg of oral meloxicam be given to reduce surgical recovery time in rabbits and should twice daily administration be considered? |
| title_full | Should doses exceeding 0.2 mg/kg of oral meloxicam be given to reduce surgical recovery time in rabbits and should twice daily administration be considered? |
| title_fullStr | Should doses exceeding 0.2 mg/kg of oral meloxicam be given to reduce surgical recovery time in rabbits and should twice daily administration be considered? |
| title_full_unstemmed | Should doses exceeding 0.2 mg/kg of oral meloxicam be given to reduce surgical recovery time in rabbits and should twice daily administration be considered? |
| title_short | Should doses exceeding 0.2 mg/kg of oral meloxicam be given to reduce surgical recovery time in rabbits and should twice daily administration be considered? |
| title_sort | should doses exceeding 0 2 mg kg of oral meloxicam be given to reduce surgical recovery time in rabbits and should twice daily administration be considered |
| topic | postoperative analgesia oral meloxicam rabbit analgesia daily meloxicam administration postsurgical management meloxicam rabbits oryctolagus cuniculus |
| url | https://veterinaryevidence.org/index.php/ve/article/view/372 |
| work_keys_str_mv | AT eleanorbest shoulddosesexceeding02mgkgoforalmeloxicambegiventoreducesurgicalrecoverytimeinrabbitsandshouldtwicedailyadministrationbeconsidered |