Retrospective correlation analysis of plasma Immunoglobulin G and clinical performance in CIDP
Background Chronic inflammatory demyelinating polyneuropathy (CIDP) can be successfully treated with immunoglobulin either intravenously (IVIG) or subcutaneously (SCIG). Measurement of plasma immunoglobulin G levels (P-IgG) and its correlation to clinical improvement has shown conflicting results. T...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PeerJ Inc.
2019-05-01
|
| Series: | PeerJ |
| Subjects: | |
| Online Access: | https://peerj.com/articles/6969.pdf |
| _version_ | 1797418567081132032 |
|---|---|
| author | Lars Kjøbsted Markvardsen Stine Bruun-Sørensen Ingelise Christiansen Henning Andersen |
| author_facet | Lars Kjøbsted Markvardsen Stine Bruun-Sørensen Ingelise Christiansen Henning Andersen |
| author_sort | Lars Kjøbsted Markvardsen |
| collection | DOAJ |
| description | Background Chronic inflammatory demyelinating polyneuropathy (CIDP) can be successfully treated with immunoglobulin either intravenously (IVIG) or subcutaneously (SCIG). Measurement of plasma immunoglobulin G levels (P-IgG) and its correlation to clinical improvement has shown conflicting results. This study aims to clarify whether changes in P-IgG are related to clinical development in patients with CIDP treated with IVIG or SCIG. Methods Patients from five previous studies treated with either IVIG or SCIG with evaluation at baseline and re-evaluation after two or 10/12 weeks, respectively were included. At evaluation and re-evaluation, the following tests were done: combined isokinetic muscle strength (cIKS), grip strength, 9-hole-peg test (9-HPT), 40-meter-walk test (40-MWT), clinical examination of muscle strength score by the Medical Research Council (MRC) and measurement of plasma immunoglobulin G (P-IgG). Results Fifty-five patients were included in the IVIG group and 41 in the SCIG group. There was no correlation between the changes in P-IgG and cIKS in neither the IVIG group (r = 0.137, p = 0.32) nor the SCIG group (r = − 0.048, p = 0.77). Similarly, no correlations could be demonstrated between P-IgG and grip strength, 9-HPT, 40-MWT or MRC. Conclusions In patients with CIDP receiving SCIG or IVIG, changes in P-IgG during treatment did not correlate with changes in muscle strength or other motor performance skills. |
| first_indexed | 2024-03-09T06:34:47Z |
| format | Article |
| id | doaj.art-f97446aaf4e9464a8622066e990fca8a |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:34:47Z |
| publishDate | 2019-05-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-f97446aaf4e9464a8622066e990fca8a2023-12-03T11:01:12ZengPeerJ Inc.PeerJ2167-83592019-05-017e696910.7717/peerj.6969Retrospective correlation analysis of plasma Immunoglobulin G and clinical performance in CIDPLars Kjøbsted Markvardsen0Stine Bruun-Sørensen1Ingelise Christiansen2Henning Andersen3Department of Neurology, Aarhus University Hospital, Aarhus, DenmarkDepartment of Neurology, Aarhus University Hospital, Aarhus, DenmarkDepartment of Neurology, Rigshospitalet, Copenhagen, DenmarkDepartment of Neurology, Aarhus University Hospital, Aarhus, DenmarkBackground Chronic inflammatory demyelinating polyneuropathy (CIDP) can be successfully treated with immunoglobulin either intravenously (IVIG) or subcutaneously (SCIG). Measurement of plasma immunoglobulin G levels (P-IgG) and its correlation to clinical improvement has shown conflicting results. This study aims to clarify whether changes in P-IgG are related to clinical development in patients with CIDP treated with IVIG or SCIG. Methods Patients from five previous studies treated with either IVIG or SCIG with evaluation at baseline and re-evaluation after two or 10/12 weeks, respectively were included. At evaluation and re-evaluation, the following tests were done: combined isokinetic muscle strength (cIKS), grip strength, 9-hole-peg test (9-HPT), 40-meter-walk test (40-MWT), clinical examination of muscle strength score by the Medical Research Council (MRC) and measurement of plasma immunoglobulin G (P-IgG). Results Fifty-five patients were included in the IVIG group and 41 in the SCIG group. There was no correlation between the changes in P-IgG and cIKS in neither the IVIG group (r = 0.137, p = 0.32) nor the SCIG group (r = − 0.048, p = 0.77). Similarly, no correlations could be demonstrated between P-IgG and grip strength, 9-HPT, 40-MWT or MRC. Conclusions In patients with CIDP receiving SCIG or IVIG, changes in P-IgG during treatment did not correlate with changes in muscle strength or other motor performance skills.https://peerj.com/articles/6969.pdfMuscle strengthCIDPPlasma immunoglobulin GIVIGSCIG |
| spellingShingle | Lars Kjøbsted Markvardsen Stine Bruun-Sørensen Ingelise Christiansen Henning Andersen Retrospective correlation analysis of plasma Immunoglobulin G and clinical performance in CIDP PeerJ Muscle strength CIDP Plasma immunoglobulin G IVIG SCIG |
| title | Retrospective correlation analysis of plasma Immunoglobulin G and clinical performance in CIDP |
| title_full | Retrospective correlation analysis of plasma Immunoglobulin G and clinical performance in CIDP |
| title_fullStr | Retrospective correlation analysis of plasma Immunoglobulin G and clinical performance in CIDP |
| title_full_unstemmed | Retrospective correlation analysis of plasma Immunoglobulin G and clinical performance in CIDP |
| title_short | Retrospective correlation analysis of plasma Immunoglobulin G and clinical performance in CIDP |
| title_sort | retrospective correlation analysis of plasma immunoglobulin g and clinical performance in cidp |
| topic | Muscle strength CIDP Plasma immunoglobulin G IVIG SCIG |
| url | https://peerj.com/articles/6969.pdf |
| work_keys_str_mv | AT larskjøbstedmarkvardsen retrospectivecorrelationanalysisofplasmaimmunoglobulingandclinicalperformanceincidp AT stinebruunsørensen retrospectivecorrelationanalysisofplasmaimmunoglobulingandclinicalperformanceincidp AT ingelisechristiansen retrospectivecorrelationanalysisofplasmaimmunoglobulingandclinicalperformanceincidp AT henningandersen retrospectivecorrelationanalysisofplasmaimmunoglobulingandclinicalperformanceincidp |