Association of triglyceride-glucose index with prognosis of COVID-19: A population-based study
Background: Triglyceride-glucose (TyG) index is a simple and reliable surrogate marker for insulin resistance. Epidemiology studies have shown that insulin resistance is a risk factor for various infectious diseases. We evaluated the prognostic value of TyG index measured before the COVID-19 infecti...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Journal of Infection and Public Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034122001587 |
| _version_ | 1828375315789905920 |
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| author | Yoonkyung Chang Jimin Jeon Tae-Jin Song Jinkwon Kim |
| author_facet | Yoonkyung Chang Jimin Jeon Tae-Jin Song Jinkwon Kim |
| author_sort | Yoonkyung Chang |
| collection | DOAJ |
| description | Background: Triglyceride-glucose (TyG) index is a simple and reliable surrogate marker for insulin resistance. Epidemiology studies have shown that insulin resistance is a risk factor for various infectious diseases. We evaluated the prognostic value of TyG index measured before the COVID-19 infection in COVID-19 infected patients. Methods: From a nationwide COVID-19 cohort dataset in Korea, we included COVID-19 patients diagnosed between Jan and Jun 2020. Based on the nationwide health screening data between 2015 and 2018, TyG index was calculated as ln [triglyceride (mg/dL) × fasting glucose level (mg/dL)/2]. Primary outcome is development of severe complications of COVID-19 defined as composite of mechanical ventilation, intensive care unit care, high-flow oxygen therapy, and mortality within two months after the diagnosis of COVID-19. Results: This study included 3887 patients with COVID-19 confirmed by reverse transcription polymerase chain reaction. Mean ± standard deviation of TyG index was 8.54 ± 0.61. Severe complications of COVID-19 were noted in 289 (7.44%) patients. In the multivariate logistic regression, TyG index was positively associated with severe complications of COVID-19 (adjusted odds ratio: 1.42, 95% confidence interval [1.12–1.79]). Conclusions: In COVID-19 infected patients, high TyG index was associated with increased risk for severe complications. TyG index might be useful predictor for the severity of COVID-19 infection. |
| first_indexed | 2024-04-14T07:44:49Z |
| format | Article |
| id | doaj.art-f97874ca39dd45afa22478a21af13eb9 |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-04-14T07:44:49Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-f97874ca39dd45afa22478a21af13eb92022-12-22T02:05:23ZengElsevierJournal of Infection and Public Health1876-03412022-08-01158837844Association of triglyceride-glucose index with prognosis of COVID-19: A population-based studyYoonkyung Chang0Jimin Jeon1Tae-Jin Song2Jinkwon Kim3Department of Neurology, Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Republic of KoreaDepartment of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, Republic of KoreaDepartment of Neurology, Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea; Correspondence to: Department of Neurology, Seoul Hospital, Ewha Womans University College of Medicine, 260, Gonghang-daero, Gangseo-gu, 07804 Seoul, Republic of Korea.Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, Republic of Korea; Correspondence to: Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin-si 16995, Republic of Korea.Background: Triglyceride-glucose (TyG) index is a simple and reliable surrogate marker for insulin resistance. Epidemiology studies have shown that insulin resistance is a risk factor for various infectious diseases. We evaluated the prognostic value of TyG index measured before the COVID-19 infection in COVID-19 infected patients. Methods: From a nationwide COVID-19 cohort dataset in Korea, we included COVID-19 patients diagnosed between Jan and Jun 2020. Based on the nationwide health screening data between 2015 and 2018, TyG index was calculated as ln [triglyceride (mg/dL) × fasting glucose level (mg/dL)/2]. Primary outcome is development of severe complications of COVID-19 defined as composite of mechanical ventilation, intensive care unit care, high-flow oxygen therapy, and mortality within two months after the diagnosis of COVID-19. Results: This study included 3887 patients with COVID-19 confirmed by reverse transcription polymerase chain reaction. Mean ± standard deviation of TyG index was 8.54 ± 0.61. Severe complications of COVID-19 were noted in 289 (7.44%) patients. In the multivariate logistic regression, TyG index was positively associated with severe complications of COVID-19 (adjusted odds ratio: 1.42, 95% confidence interval [1.12–1.79]). Conclusions: In COVID-19 infected patients, high TyG index was associated with increased risk for severe complications. TyG index might be useful predictor for the severity of COVID-19 infection.http://www.sciencedirect.com/science/article/pii/S1876034122001587COVID-19Insulin resistanceTriglyceride-glucose indexGlucose |
| spellingShingle | Yoonkyung Chang Jimin Jeon Tae-Jin Song Jinkwon Kim Association of triglyceride-glucose index with prognosis of COVID-19: A population-based study Journal of Infection and Public Health COVID-19 Insulin resistance Triglyceride-glucose index Glucose |
| title | Association of triglyceride-glucose index with prognosis of COVID-19: A population-based study |
| title_full | Association of triglyceride-glucose index with prognosis of COVID-19: A population-based study |
| title_fullStr | Association of triglyceride-glucose index with prognosis of COVID-19: A population-based study |
| title_full_unstemmed | Association of triglyceride-glucose index with prognosis of COVID-19: A population-based study |
| title_short | Association of triglyceride-glucose index with prognosis of COVID-19: A population-based study |
| title_sort | association of triglyceride glucose index with prognosis of covid 19 a population based study |
| topic | COVID-19 Insulin resistance Triglyceride-glucose index Glucose |
| url | http://www.sciencedirect.com/science/article/pii/S1876034122001587 |
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