Effect of Dietary Fiber on the Composition of the Murine Dental Microbiome
The oral cavity houses a diverse consortium of microorganisms, heavily influenced by host diet, that can mediate dental health and disease. While the impact of dietary carbohydrates to the dental microbiome has been well-documented, the effect of fiber as a mechanical influence on the dental microbi...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-06-01
|
| Series: | Dentistry Journal |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-6767/7/2/58 |
| _version_ | 1817990729679503360 |
|---|---|
| author | Lea Sedghi Craig Byron Ryan Jennings George E. Chlipala Stefan J. Green Laura Silo-Suh |
| author_facet | Lea Sedghi Craig Byron Ryan Jennings George E. Chlipala Stefan J. Green Laura Silo-Suh |
| author_sort | Lea Sedghi |
| collection | DOAJ |
| description | The oral cavity houses a diverse consortium of microorganisms, heavily influenced by host diet, that can mediate dental health and disease. While the impact of dietary carbohydrates to the dental microbiome has been well-documented, the effect of fiber as a mechanical influence on the dental microbiome is unexplored. We performed 16S rRNA gene analysis to investigate the response of the dental microbiome to the presence of increased fiber in terms of microbial taxonomic abundance and diversity. Dental microbial community structure was significantly different in mice fed a diet supplemented with increased fiber and/or sugar. Fiber significantly affected measures of beta diversity at the phylum and genus levels, and a strong interactive effect on alpha diversity was observed between sugar and fiber at the phylum level. The addition of fiber also induced significant variation in relative taxonomic abundance. This study demonstrates that fiber can promote significant variations in the mouse dental microbiome. |
| first_indexed | 2024-04-14T01:02:55Z |
| format | Article |
| id | doaj.art-f978d0a1a56c40e9b5293880ece4c1cf |
| institution | Directory Open Access Journal |
| issn | 2304-6767 |
| language | English |
| last_indexed | 2024-04-14T01:02:55Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Dentistry Journal |
| spelling | doaj.art-f978d0a1a56c40e9b5293880ece4c1cf2022-12-22T02:21:21ZengMDPI AGDentistry Journal2304-67672019-06-01725810.3390/dj7020058dj7020058Effect of Dietary Fiber on the Composition of the Murine Dental MicrobiomeLea Sedghi0Craig Byron1Ryan Jennings2George E. Chlipala3Stefan J. Green4Laura Silo-Suh5Department of BioMedical Sciences, School of Medicine, Mercer University, Macon, GA 31207, USADepartment of Biology, Mercer University, Macon, GA 31207, USADepartment of Biology, Frostburg State University, Frostburg, MD 21532-2303, USAResearch Resources Center, University of Illinois at Chicago, Chicago, IL 60612-3748, USAResearch Resources Center, University of Illinois at Chicago, Chicago, IL 60612-3748, USADepartment of BioMedical Sciences, School of Medicine, Mercer University, Macon, GA 31207, USAThe oral cavity houses a diverse consortium of microorganisms, heavily influenced by host diet, that can mediate dental health and disease. While the impact of dietary carbohydrates to the dental microbiome has been well-documented, the effect of fiber as a mechanical influence on the dental microbiome is unexplored. We performed 16S rRNA gene analysis to investigate the response of the dental microbiome to the presence of increased fiber in terms of microbial taxonomic abundance and diversity. Dental microbial community structure was significantly different in mice fed a diet supplemented with increased fiber and/or sugar. Fiber significantly affected measures of beta diversity at the phylum and genus levels, and a strong interactive effect on alpha diversity was observed between sugar and fiber at the phylum level. The addition of fiber also induced significant variation in relative taxonomic abundance. This study demonstrates that fiber can promote significant variations in the mouse dental microbiome.https://www.mdpi.com/2304-6767/7/2/58dental microbiomedietary sugardietary fiber16Sbiofilm |
| spellingShingle | Lea Sedghi Craig Byron Ryan Jennings George E. Chlipala Stefan J. Green Laura Silo-Suh Effect of Dietary Fiber on the Composition of the Murine Dental Microbiome Dentistry Journal dental microbiome dietary sugar dietary fiber 16S biofilm |
| title | Effect of Dietary Fiber on the Composition of the Murine Dental Microbiome |
| title_full | Effect of Dietary Fiber on the Composition of the Murine Dental Microbiome |
| title_fullStr | Effect of Dietary Fiber on the Composition of the Murine Dental Microbiome |
| title_full_unstemmed | Effect of Dietary Fiber on the Composition of the Murine Dental Microbiome |
| title_short | Effect of Dietary Fiber on the Composition of the Murine Dental Microbiome |
| title_sort | effect of dietary fiber on the composition of the murine dental microbiome |
| topic | dental microbiome dietary sugar dietary fiber 16S biofilm |
| url | https://www.mdpi.com/2304-6767/7/2/58 |
| work_keys_str_mv | AT leasedghi effectofdietaryfiberonthecompositionofthemurinedentalmicrobiome AT craigbyron effectofdietaryfiberonthecompositionofthemurinedentalmicrobiome AT ryanjennings effectofdietaryfiberonthecompositionofthemurinedentalmicrobiome AT georgeechlipala effectofdietaryfiberonthecompositionofthemurinedentalmicrobiome AT stefanjgreen effectofdietaryfiberonthecompositionofthemurinedentalmicrobiome AT laurasilosuh effectofdietaryfiberonthecompositionofthemurinedentalmicrobiome |