Cognitive performance in relation to urinary anthocyanins and their flavonoid-based products following blueberry supplementation in older adults at risk for dementia
We performed a randomized, double blind, placebo-controlled trial with blueberry supplementation in older adults with mild cognitive impairment. We measured cognitive performance and parent (unmodified food form) anthocyanins and a suite of flavonoid-based phase 2 metabolites arising from anthocyani...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619305912 |
| _version_ | 1818415642984841216 |
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| author | Robert Krikorian Wilhelmina Kalt Jane E. McDonald Marcelle D. Shidler Suzanne S. Summer Amanda L. Stein |
| author_facet | Robert Krikorian Wilhelmina Kalt Jane E. McDonald Marcelle D. Shidler Suzanne S. Summer Amanda L. Stein |
| author_sort | Robert Krikorian |
| collection | DOAJ |
| description | We performed a randomized, double blind, placebo-controlled trial with blueberry supplementation in older adults with mild cognitive impairment. We measured cognitive performance and parent (unmodified food form) anthocyanins and a suite of flavonoid-based phase 2 metabolites arising from anthocyanins in urine. The blueberry-treated group exhibited improved semantic access (p = 0.01) and visual-spatial memory (p = 0.05), and there was a trend for enhanced speed of processing (p = 0.08). There was no group difference in urinary excretion of total anthocyanins (parent plus metabolite forms) due to an abundance of phase 2 metabolites in both groups. However, parent anthocyanins (less than 0.1% of total) were 100 times greater in the blueberry group and were correlated with neurocognitive benefit. Ongoing blueberry intake introduced in advance of dementia improved cognitive performance, which was correlated specifically with the recent intake of blueberry and an abundance of parent anthocyanins. |
| first_indexed | 2024-12-14T11:38:15Z |
| format | Article |
| id | doaj.art-f97a480fd0b54f608d44ba3237fa688d |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T11:38:15Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-f97a480fd0b54f608d44ba3237fa688d2022-12-21T23:02:56ZengElsevierJournal of Functional Foods1756-46462020-01-0164103667Cognitive performance in relation to urinary anthocyanins and their flavonoid-based products following blueberry supplementation in older adults at risk for dementiaRobert Krikorian0Wilhelmina Kalt1Jane E. McDonald2Marcelle D. Shidler3Suzanne S. Summer4Amanda L. Stein5Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati Academic Health Center, Cincinnati, OH, USA; Corresponding author at: Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati Academic Health Center, PO Box 670559, Cincinnati, OH 45267-0559 USA.Agriculture and Agri-Food Canada, Kentville Research and Development Centre, Kentville, Nova Scotia, CanadaAgriculture and Agri-Food Canada, Kentville Research and Development Centre, Kentville, Nova Scotia, CanadaDepartment of Psychiatry & Behavioral Neuroscience, University of Cincinnati Academic Health Center, Cincinnati, OH, USAClinical Translational Research Center, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USADepartment of Psychiatry & Behavioral Neuroscience, University of Cincinnati Academic Health Center, Cincinnati, OH, USAWe performed a randomized, double blind, placebo-controlled trial with blueberry supplementation in older adults with mild cognitive impairment. We measured cognitive performance and parent (unmodified food form) anthocyanins and a suite of flavonoid-based phase 2 metabolites arising from anthocyanins in urine. The blueberry-treated group exhibited improved semantic access (p = 0.01) and visual-spatial memory (p = 0.05), and there was a trend for enhanced speed of processing (p = 0.08). There was no group difference in urinary excretion of total anthocyanins (parent plus metabolite forms) due to an abundance of phase 2 metabolites in both groups. However, parent anthocyanins (less than 0.1% of total) were 100 times greater in the blueberry group and were correlated with neurocognitive benefit. Ongoing blueberry intake introduced in advance of dementia improved cognitive performance, which was correlated specifically with the recent intake of blueberry and an abundance of parent anthocyanins.http://www.sciencedirect.com/science/article/pii/S1756464619305912BlueberriesAnthocyaninsPhase 2 metabolitesMild cognitive impairmentDementia |
| spellingShingle | Robert Krikorian Wilhelmina Kalt Jane E. McDonald Marcelle D. Shidler Suzanne S. Summer Amanda L. Stein Cognitive performance in relation to urinary anthocyanins and their flavonoid-based products following blueberry supplementation in older adults at risk for dementia Journal of Functional Foods Blueberries Anthocyanins Phase 2 metabolites Mild cognitive impairment Dementia |
| title | Cognitive performance in relation to urinary anthocyanins and their flavonoid-based products following blueberry supplementation in older adults at risk for dementia |
| title_full | Cognitive performance in relation to urinary anthocyanins and their flavonoid-based products following blueberry supplementation in older adults at risk for dementia |
| title_fullStr | Cognitive performance in relation to urinary anthocyanins and their flavonoid-based products following blueberry supplementation in older adults at risk for dementia |
| title_full_unstemmed | Cognitive performance in relation to urinary anthocyanins and their flavonoid-based products following blueberry supplementation in older adults at risk for dementia |
| title_short | Cognitive performance in relation to urinary anthocyanins and their flavonoid-based products following blueberry supplementation in older adults at risk for dementia |
| title_sort | cognitive performance in relation to urinary anthocyanins and their flavonoid based products following blueberry supplementation in older adults at risk for dementia |
| topic | Blueberries Anthocyanins Phase 2 metabolites Mild cognitive impairment Dementia |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619305912 |
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