Cooperative binding.
Molecular binding is an interaction between molecules that results in a stable association between those molecules. Cooperative binding occurs if the number of binding sites of a macromolecule that are occupied by a specific type of ligand is a nonlinear function of this ligand's concentration....
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23843752/?tool=EBI |
| _version_ | 1818972270837628928 |
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| author | Melanie I Stefan Nicolas Le Novère |
| author_facet | Melanie I Stefan Nicolas Le Novère |
| author_sort | Melanie I Stefan |
| collection | DOAJ |
| description | Molecular binding is an interaction between molecules that results in a stable association between those molecules. Cooperative binding occurs if the number of binding sites of a macromolecule that are occupied by a specific type of ligand is a nonlinear function of this ligand's concentration. This can be due, for instance, to an affinity for the ligand that depends on the amount of ligand bound. Cooperativity can be positive (supralinear) or negative (infralinear). Cooperative binding is most often observed in proteins, but nucleic acids can also exhibit cooperative binding, for instance of transcription factors. Cooperative binding has been shown to be the mechanism underlying a large range of biochemical and physiological processes. |
| first_indexed | 2024-12-20T15:05:36Z |
| format | Article |
| id | doaj.art-f97e7b74fd5e4da9a2a7ad0682baa302 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-20T15:05:36Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-f97e7b74fd5e4da9a2a7ad0682baa3022022-12-21T19:36:31ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582013-01-0196e100310610.1371/journal.pcbi.1003106Cooperative binding.Melanie I StefanNicolas Le NovèreMolecular binding is an interaction between molecules that results in a stable association between those molecules. Cooperative binding occurs if the number of binding sites of a macromolecule that are occupied by a specific type of ligand is a nonlinear function of this ligand's concentration. This can be due, for instance, to an affinity for the ligand that depends on the amount of ligand bound. Cooperativity can be positive (supralinear) or negative (infralinear). Cooperative binding is most often observed in proteins, but nucleic acids can also exhibit cooperative binding, for instance of transcription factors. Cooperative binding has been shown to be the mechanism underlying a large range of biochemical and physiological processes.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23843752/?tool=EBI |
| spellingShingle | Melanie I Stefan Nicolas Le Novère Cooperative binding. PLoS Computational Biology |
| title | Cooperative binding. |
| title_full | Cooperative binding. |
| title_fullStr | Cooperative binding. |
| title_full_unstemmed | Cooperative binding. |
| title_short | Cooperative binding. |
| title_sort | cooperative binding |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23843752/?tool=EBI |
| work_keys_str_mv | AT melanieistefan cooperativebinding AT nicolaslenovere cooperativebinding |