Principles of cellular resource allocation revealed by condition-dependent proteome profiling

Principles of cellular resource allocation revealed by condition-dependent proteome profiling

Growing cells coordinate protein translation with metabolic rates. Central to this coordination is ribosome production. Ribosomes drive cell growth, but translation of ribosomal proteins competes with production of non-ribosomal proteins. Theory shows that cell growth is maximized when all expressed...

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Bibliographic Details
Main Authors: Eyal Metzl-Raz, Moshe Kafri, Gilad Yaakov, Ilya Soifer, Yonat Gurvich, Naama Barkai
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
translation
transcription
ribosomes
resource allocation
proteome
Online Access:https://elifesciences.org/articles/28034

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