Effect of ionization of drug on drug solubilization in SMEDDS prepared using Capmul MCM and caprylic acid
The purpose of this study was to investigate the effect of ionization of drug on drug solubilization in SMEDDS (self-microemulsifying drug delivery system) prepared using Capmul MCM and caprylic acid. Solubilization capacity of blank SMEDDS dispersions for danazol, indomethacin and haloperidol as mo...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-01-01
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| Series: | Asian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087616301696 |
| _version_ | 1818518869927526400 |
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| author | Suhua Li Parshotam Madan Senshang Lin |
| author_facet | Suhua Li Parshotam Madan Senshang Lin |
| author_sort | Suhua Li |
| collection | DOAJ |
| description | The purpose of this study was to investigate the effect of ionization of drug on drug solubilization in SMEDDS (self-microemulsifying drug delivery system) prepared using Capmul MCM and caprylic acid. Solubilization capacity of blank SMEDDS dispersions for danazol, indomethacin and haloperidol as model drugs was determined. Based on the outcomes of solubilization capacity study, drug-loaded SMEDDS formulations were prepared and subjected to dispersion/precipitation study and droplet size analysis. Blank SMEDDS dispersions exhibited the highest solubilization capacity for haloperidol followed by indomethacin and danazol. Furthermore, the solubilization of the three drugs in blank SMEDDS dispersions was explained by a modified mathematical model. Dispersion/precipitation studies indicate that drug-loaded SMEDDS formulations exhibited superiority in solubilizing the drugs in comparison to their respective drug powder. In addition, indomethacin and haloperidol were found to reduce the droplet size of the microemulsions while danazol did not affect droplet size formation for drug-loaded SMEDDS formulations. These findings suggest that ionization of drug affects drug solubilization, droplet size formation, drug loading and drug dispersion/precipitation profiles for the SMEDDS formulations. |
| first_indexed | 2024-12-11T01:16:14Z |
| format | Article |
| id | doaj.art-f980dc909f5a4860a13d1c565fcd96dc |
| institution | Directory Open Access Journal |
| issn | 1818-0876 |
| language | English |
| last_indexed | 2024-12-11T01:16:14Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-f980dc909f5a4860a13d1c565fcd96dc2022-12-22T01:25:52ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762017-01-01121738210.1016/j.ajps.2016.10.001Effect of ionization of drug on drug solubilization in SMEDDS prepared using Capmul MCM and caprylic acidSuhua LiParshotam MadanSenshang LinThe purpose of this study was to investigate the effect of ionization of drug on drug solubilization in SMEDDS (self-microemulsifying drug delivery system) prepared using Capmul MCM and caprylic acid. Solubilization capacity of blank SMEDDS dispersions for danazol, indomethacin and haloperidol as model drugs was determined. Based on the outcomes of solubilization capacity study, drug-loaded SMEDDS formulations were prepared and subjected to dispersion/precipitation study and droplet size analysis. Blank SMEDDS dispersions exhibited the highest solubilization capacity for haloperidol followed by indomethacin and danazol. Furthermore, the solubilization of the three drugs in blank SMEDDS dispersions was explained by a modified mathematical model. Dispersion/precipitation studies indicate that drug-loaded SMEDDS formulations exhibited superiority in solubilizing the drugs in comparison to their respective drug powder. In addition, indomethacin and haloperidol were found to reduce the droplet size of the microemulsions while danazol did not affect droplet size formation for drug-loaded SMEDDS formulations. These findings suggest that ionization of drug affects drug solubilization, droplet size formation, drug loading and drug dispersion/precipitation profiles for the SMEDDS formulations.http://www.sciencedirect.com/science/article/pii/S1818087616301696SMEDDSCapmul MCMCaprylic acidIonizationIndomethacinHaloperidol |
| spellingShingle | Suhua Li Parshotam Madan Senshang Lin Effect of ionization of drug on drug solubilization in SMEDDS prepared using Capmul MCM and caprylic acid Asian Journal of Pharmaceutical Sciences SMEDDS Capmul MCM Caprylic acid Ionization Indomethacin Haloperidol |
| title | Effect of ionization of drug on drug solubilization in SMEDDS prepared using Capmul MCM and caprylic acid |
| title_full | Effect of ionization of drug on drug solubilization in SMEDDS prepared using Capmul MCM and caprylic acid |
| title_fullStr | Effect of ionization of drug on drug solubilization in SMEDDS prepared using Capmul MCM and caprylic acid |
| title_full_unstemmed | Effect of ionization of drug on drug solubilization in SMEDDS prepared using Capmul MCM and caprylic acid |
| title_short | Effect of ionization of drug on drug solubilization in SMEDDS prepared using Capmul MCM and caprylic acid |
| title_sort | effect of ionization of drug on drug solubilization in smedds prepared using capmul mcm and caprylic acid |
| topic | SMEDDS Capmul MCM Caprylic acid Ionization Indomethacin Haloperidol |
| url | http://www.sciencedirect.com/science/article/pii/S1818087616301696 |
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