Macrophages in acne vulgaris: mediating phagocytosis, inflammation, scar formation, and therapeutic implications
Macrophages serve as a pivotal nexus in the pathogenesis of acne vulgaris, orchestrating both the elimination of Cutibacterium acnes (C. acnes) and lipid metabolic regulation while also possessing the capacity to exacerbate inflammation and induce cutaneous scarring. Additionally, recent investigati...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1355455/full |
| _version_ | 1797263097223708672 |
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| author | Yibo Feng Jiaqi Li Xiaohui Mo Qiang Ju |
| author_facet | Yibo Feng Jiaqi Li Xiaohui Mo Qiang Ju |
| author_sort | Yibo Feng |
| collection | DOAJ |
| description | Macrophages serve as a pivotal nexus in the pathogenesis of acne vulgaris, orchestrating both the elimination of Cutibacterium acnes (C. acnes) and lipid metabolic regulation while also possessing the capacity to exacerbate inflammation and induce cutaneous scarring. Additionally, recent investigations underscore the therapeutic potential inherent in macrophage modulation and challenge current anti-inflammatory strategies for acne vulgaris. This review distills contemporary advances, specifically examining the dual roles of macrophages, underlying regulatory frameworks, and emergent therapeutic avenues. Such nuanced insights hold the promise of guiding future explorations into the molecular etiology of acne and the development of more efficacious treatment modalities. |
| first_indexed | 2024-04-25T00:07:35Z |
| format | Article |
| id | doaj.art-f98110308414482080c03377a8fc5224 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-25T00:07:35Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f98110308414482080c03377a8fc52242024-03-14T04:47:18ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-03-011510.3389/fimmu.2024.13554551355455Macrophages in acne vulgaris: mediating phagocytosis, inflammation, scar formation, and therapeutic implicationsYibo FengJiaqi LiXiaohui MoQiang JuMacrophages serve as a pivotal nexus in the pathogenesis of acne vulgaris, orchestrating both the elimination of Cutibacterium acnes (C. acnes) and lipid metabolic regulation while also possessing the capacity to exacerbate inflammation and induce cutaneous scarring. Additionally, recent investigations underscore the therapeutic potential inherent in macrophage modulation and challenge current anti-inflammatory strategies for acne vulgaris. This review distills contemporary advances, specifically examining the dual roles of macrophages, underlying regulatory frameworks, and emergent therapeutic avenues. Such nuanced insights hold the promise of guiding future explorations into the molecular etiology of acne and the development of more efficacious treatment modalities.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1355455/fullacne vulgarismacrophagesCutibacterium acnesinflammationtherapeutics |
| spellingShingle | Yibo Feng Jiaqi Li Xiaohui Mo Qiang Ju Macrophages in acne vulgaris: mediating phagocytosis, inflammation, scar formation, and therapeutic implications Frontiers in Immunology acne vulgaris macrophages Cutibacterium acnes inflammation therapeutics |
| title | Macrophages in acne vulgaris: mediating phagocytosis, inflammation, scar formation, and therapeutic implications |
| title_full | Macrophages in acne vulgaris: mediating phagocytosis, inflammation, scar formation, and therapeutic implications |
| title_fullStr | Macrophages in acne vulgaris: mediating phagocytosis, inflammation, scar formation, and therapeutic implications |
| title_full_unstemmed | Macrophages in acne vulgaris: mediating phagocytosis, inflammation, scar formation, and therapeutic implications |
| title_short | Macrophages in acne vulgaris: mediating phagocytosis, inflammation, scar formation, and therapeutic implications |
| title_sort | macrophages in acne vulgaris mediating phagocytosis inflammation scar formation and therapeutic implications |
| topic | acne vulgaris macrophages Cutibacterium acnes inflammation therapeutics |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1355455/full |
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