The Potential Role of Growth Hormone on the Endometrium in Assisted Reproductive Technology
Growth hormone (GH) has been considered as an adjuvant treatment in human assisted reproductive technology (ART) for several years. Its action was largely attributed to an improvement of ovarian function and less emphasis was paid to its role in the uterus. However, there is increasing evidence that...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-02-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2020.00049/full |
| _version_ | 1811291601113186304 |
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| author | Fen-Ting Liu Ze Wu Jie Yan Robert J. Norman Rong Li |
| author_facet | Fen-Ting Liu Ze Wu Jie Yan Robert J. Norman Rong Li |
| author_sort | Fen-Ting Liu |
| collection | DOAJ |
| description | Growth hormone (GH) has been considered as an adjuvant treatment in human assisted reproductive technology (ART) for several years. Its action was largely attributed to an improvement of ovarian function and less emphasis was paid to its role in the uterus. However, there is increasing evidence that GH and its receptors are expressed and have actions in the endometrium and may play an important role in modifying endometrial receptivity. Thus, in this review, we firstly describe the existence of GH receptors in endometrium and then summarize the effects of GH on the endometrium in clinical situations and the underlying mechanisms of GH in the regulation of endometrial receptivity. Finally, we briefly review the potential risks of GH in ART and consider rationalized use of GH treatment in ART. |
| first_indexed | 2024-04-13T04:31:54Z |
| format | Article |
| id | doaj.art-f981cc7000a64bae81ac51208be944ad |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-13T04:31:54Z |
| publishDate | 2020-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-f981cc7000a64bae81ac51208be944ad2022-12-22T03:02:18ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-02-011110.3389/fendo.2020.00049496462The Potential Role of Growth Hormone on the Endometrium in Assisted Reproductive TechnologyFen-Ting Liu0Ze Wu1Jie Yan2Robert J. Norman3Rong Li4Ministry of Education Key Laboratory of Assisted Reproduction, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Center of Reproductive Medicine, Peking University Third Hospital, Beijing, ChinaDepartment of Reproductive Medicine, The First People's Hospital of Yunnan Province, Kunming, ChinaMinistry of Education Key Laboratory of Assisted Reproduction, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Center of Reproductive Medicine, Peking University Third Hospital, Beijing, ChinaRobinson Research Institute and Fertility SA, University of Adelaide, Adelaide, SA, AustraliaMinistry of Education Key Laboratory of Assisted Reproduction, Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Center of Reproductive Medicine, Peking University Third Hospital, Beijing, ChinaGrowth hormone (GH) has been considered as an adjuvant treatment in human assisted reproductive technology (ART) for several years. Its action was largely attributed to an improvement of ovarian function and less emphasis was paid to its role in the uterus. However, there is increasing evidence that GH and its receptors are expressed and have actions in the endometrium and may play an important role in modifying endometrial receptivity. Thus, in this review, we firstly describe the existence of GH receptors in endometrium and then summarize the effects of GH on the endometrium in clinical situations and the underlying mechanisms of GH in the regulation of endometrial receptivity. Finally, we briefly review the potential risks of GH in ART and consider rationalized use of GH treatment in ART.https://www.frontiersin.org/article/10.3389/fendo.2020.00049/fullgrowth hormoneendometrial receptivitymechanismsriskART |
| spellingShingle | Fen-Ting Liu Ze Wu Jie Yan Robert J. Norman Rong Li The Potential Role of Growth Hormone on the Endometrium in Assisted Reproductive Technology Frontiers in Endocrinology growth hormone endometrial receptivity mechanisms risk ART |
| title | The Potential Role of Growth Hormone on the Endometrium in Assisted Reproductive Technology |
| title_full | The Potential Role of Growth Hormone on the Endometrium in Assisted Reproductive Technology |
| title_fullStr | The Potential Role of Growth Hormone on the Endometrium in Assisted Reproductive Technology |
| title_full_unstemmed | The Potential Role of Growth Hormone on the Endometrium in Assisted Reproductive Technology |
| title_short | The Potential Role of Growth Hormone on the Endometrium in Assisted Reproductive Technology |
| title_sort | potential role of growth hormone on the endometrium in assisted reproductive technology |
| topic | growth hormone endometrial receptivity mechanisms risk ART |
| url | https://www.frontiersin.org/article/10.3389/fendo.2020.00049/full |
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