Malignant melanoma metastasis in the ileum: Two case reports
Introduction. Malignant melanoma is a tumor that develops from melanocytes, so this type of tumor can occur in any part of body containing the cells. Melanoma is less common than other skin tumors. It is very aggressive type of skin tumor with very early metastases and accounts for 75% of cases of d...
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| Format: | Article |
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Military Health Department, Ministry of Defance, Serbia
2020-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2020/0042-84501800073Z.pdf |
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| author | Živojinov Mirjana Lakić Tanja Ilić-Sabo Jelena Trivunić-Dajko Sandra Ivanov Dejan Živojinov Srđan |
| author_facet | Živojinov Mirjana Lakić Tanja Ilić-Sabo Jelena Trivunić-Dajko Sandra Ivanov Dejan Živojinov Srđan |
| author_sort | Živojinov Mirjana |
| collection | DOAJ |
| description | Introduction. Malignant melanoma is a tumor that develops from melanocytes, so this type of tumor can occur in any part of body containing the cells. Melanoma is less common than other skin tumors. It is very aggressive type of skin tumor with very early metastases and accounts for 75% of cases of death due to skin tumor. In the initial phase the tumor growth is horizontal. Early detection of changes is very important. Over time, as the tumor gets the vertical growth phase, occurrence of metastases depends on the depth of invasion (Breslow). Malignant melanoma metastasizes to regional lymph nodes, but also in the liver, lung, brain and almost any place that can be populated by the haematogenous route. Case report. We reported two cases of patients who were urgently surgically treated in the Emergency Center of Vojvodina, Serbia, with the clinical signs and symptoms of ileus. In both cases, the ileum resection was performed with terminal ileostomy. Histological analysis was performed and through morphology and immunohistochemical profile, in both cases, the diagnosis was metastatic malignant melanoma in the ileum. Conclusion. In patients with diagnosed malignant melanoma of the skin with symptoms of abdominal pain and/or anemia, application of modern imaging techniques is imperative in order to obtain an early diagnosis of gastrointestinal metastases of this tumor, because the rapid detection and radical resection may contribute to the overall survival of these patients. |
| first_indexed | 2024-12-10T13:50:18Z |
| format | Article |
| id | doaj.art-f9829c884f35438da315d0192aac9e9f |
| institution | Directory Open Access Journal |
| issn | 0042-8450 2406-0720 |
| language | English |
| last_indexed | 2024-12-10T13:50:18Z |
| publishDate | 2020-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-f9829c884f35438da315d0192aac9e9f2022-12-22T01:46:13ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502406-07202020-01-0177334434810.2298/VSP180224073Z0042-84501800073ZMalignant melanoma metastasis in the ileum: Two case reportsŽivojinov Mirjana0Lakić Tanja1Ilić-Sabo Jelena2Trivunić-Dajko Sandra3Ivanov Dejan4Živojinov Srđan5Clinical Center of Vojvodina, Center for Pathology and Histology, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaClinical Center of Vojvodina, Center for Pathology and Histology, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaClinical Center of Vojvodina, Center for Pathology and Histology, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaClinical Center of Vojvodina, Center for Pathology and Histology, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, Serbia + Clinical Center of Vojvodina, Clinic for Abdominal, Endocrine and Transplatation Surgery, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, Serbia + Clinical Center of Vojvodina, Urology Clinic, Novi Sad, SerbiaIntroduction. Malignant melanoma is a tumor that develops from melanocytes, so this type of tumor can occur in any part of body containing the cells. Melanoma is less common than other skin tumors. It is very aggressive type of skin tumor with very early metastases and accounts for 75% of cases of death due to skin tumor. In the initial phase the tumor growth is horizontal. Early detection of changes is very important. Over time, as the tumor gets the vertical growth phase, occurrence of metastases depends on the depth of invasion (Breslow). Malignant melanoma metastasizes to regional lymph nodes, but also in the liver, lung, brain and almost any place that can be populated by the haematogenous route. Case report. We reported two cases of patients who were urgently surgically treated in the Emergency Center of Vojvodina, Serbia, with the clinical signs and symptoms of ileus. In both cases, the ileum resection was performed with terminal ileostomy. Histological analysis was performed and through morphology and immunohistochemical profile, in both cases, the diagnosis was metastatic malignant melanoma in the ileum. Conclusion. In patients with diagnosed malignant melanoma of the skin with symptoms of abdominal pain and/or anemia, application of modern imaging techniques is imperative in order to obtain an early diagnosis of gastrointestinal metastases of this tumor, because the rapid detection and radical resection may contribute to the overall survival of these patients.http://www.doiserbia.nb.rs/img/doi/0042-8450/2020/0042-84501800073Z.pdfdiagnosisimmunohistochemistryileusmelanomaneoplasm metastasissurgical procedures, operativetreatment outcome |
| spellingShingle | Živojinov Mirjana Lakić Tanja Ilić-Sabo Jelena Trivunić-Dajko Sandra Ivanov Dejan Živojinov Srđan Malignant melanoma metastasis in the ileum: Two case reports Vojnosanitetski Pregled diagnosis immunohistochemistry ileus melanoma neoplasm metastasis surgical procedures, operative treatment outcome |
| title | Malignant melanoma metastasis in the ileum: Two case reports |
| title_full | Malignant melanoma metastasis in the ileum: Two case reports |
| title_fullStr | Malignant melanoma metastasis in the ileum: Two case reports |
| title_full_unstemmed | Malignant melanoma metastasis in the ileum: Two case reports |
| title_short | Malignant melanoma metastasis in the ileum: Two case reports |
| title_sort | malignant melanoma metastasis in the ileum two case reports |
| topic | diagnosis immunohistochemistry ileus melanoma neoplasm metastasis surgical procedures, operative treatment outcome |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2020/0042-84501800073Z.pdf |
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