Chlorophyll enhances oxidative stress tolerance in Caenorhabditis elegans and extends its lifespan
Green vegetables are thought to be responsible for several beneficial properties such as antioxidant, anti-mutagenic, and detoxification activities. It is not known whether these effects are due to chlorophyll which exists in large amounts in many foods or result from other secondary metabolites. In...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PeerJ Inc.
2016-04-01
|
| Series: | PeerJ |
| Subjects: | |
| Online Access: | https://peerj.com/articles/1879.pdf |
| _version_ | 1827605783393599488 |
|---|---|
| author | Erjia Wang Michael Wink |
| author_facet | Erjia Wang Michael Wink |
| author_sort | Erjia Wang |
| collection | DOAJ |
| description | Green vegetables are thought to be responsible for several beneficial properties such as antioxidant, anti-mutagenic, and detoxification activities. It is not known whether these effects are due to chlorophyll which exists in large amounts in many foods or result from other secondary metabolites. In this study, we used the model system Caenorhabditis elegans to investigate the anti-oxidative and anti-aging effects of chlorophyll in vivo. We found that chlorophyll significantly improves resistance to oxidative stress. It also enhances the lifespan of C. elegans by up to 25% via activation of the DAF-16/FOXO-dependent pathway. The results indicate that chlorophyll is absorbed by the worms and is thus bioavailable, constituting an important prerequisite for antioxidant and longevity-promoting activities inside the body. Our study thereby supports the view that green vegetables may also be beneficial for humans. |
| first_indexed | 2024-03-09T06:26:27Z |
| format | Article |
| id | doaj.art-f982b186704c408f81b711aeb43fca4b |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:26:27Z |
| publishDate | 2016-04-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-f982b186704c408f81b711aeb43fca4b2023-12-03T11:19:59ZengPeerJ Inc.PeerJ2167-83592016-04-014e187910.7717/peerj.1879Chlorophyll enhances oxidative stress tolerance in Caenorhabditis elegans and extends its lifespanErjia Wang0Michael Wink1Heidelberg University, Institute of Pharmacy and Molecular Biotechnology, Department of Biology, Heidelberg, GermanyHeidelberg University, Institute of Pharmacy and Molecular Biotechnology, Department of Biology, Heidelberg, GermanyGreen vegetables are thought to be responsible for several beneficial properties such as antioxidant, anti-mutagenic, and detoxification activities. It is not known whether these effects are due to chlorophyll which exists in large amounts in many foods or result from other secondary metabolites. In this study, we used the model system Caenorhabditis elegans to investigate the anti-oxidative and anti-aging effects of chlorophyll in vivo. We found that chlorophyll significantly improves resistance to oxidative stress. It also enhances the lifespan of C. elegans by up to 25% via activation of the DAF-16/FOXO-dependent pathway. The results indicate that chlorophyll is absorbed by the worms and is thus bioavailable, constituting an important prerequisite for antioxidant and longevity-promoting activities inside the body. Our study thereby supports the view that green vegetables may also be beneficial for humans.https://peerj.com/articles/1879.pdfChlorophyllSpinachLifespanDAF-16C. elegansAnti-aging |
| spellingShingle | Erjia Wang Michael Wink Chlorophyll enhances oxidative stress tolerance in Caenorhabditis elegans and extends its lifespan PeerJ Chlorophyll Spinach Lifespan DAF-16 C. elegans Anti-aging |
| title | Chlorophyll enhances oxidative stress tolerance in Caenorhabditis elegans and extends its lifespan |
| title_full | Chlorophyll enhances oxidative stress tolerance in Caenorhabditis elegans and extends its lifespan |
| title_fullStr | Chlorophyll enhances oxidative stress tolerance in Caenorhabditis elegans and extends its lifespan |
| title_full_unstemmed | Chlorophyll enhances oxidative stress tolerance in Caenorhabditis elegans and extends its lifespan |
| title_short | Chlorophyll enhances oxidative stress tolerance in Caenorhabditis elegans and extends its lifespan |
| title_sort | chlorophyll enhances oxidative stress tolerance in caenorhabditis elegans and extends its lifespan |
| topic | Chlorophyll Spinach Lifespan DAF-16 C. elegans Anti-aging |
| url | https://peerj.com/articles/1879.pdf |
| work_keys_str_mv | AT erjiawang chlorophyllenhancesoxidativestresstoleranceincaenorhabditiselegansandextendsitslifespan AT michaelwink chlorophyllenhancesoxidativestresstoleranceincaenorhabditiselegansandextendsitslifespan |