Special papers Diagnostic and therapeutic advances in dermatomyositis
Dermatomyositis (DM) is one of the so-called idiopathic inflammatory myopathies (IIM). Dermatomyositis is an autoimmune disorder characterized by the presence of cutaneous lesions and/or symptoms of muscle involvement with the following variants: the “classic” variant of DM, juvenile DM, paraneoplas...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2015-06-01
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| Series: | Przegląd Dermatologiczny |
| Subjects: | |
| Online Access: | http://www.termedia.pl/Special-papers-Diagnostic-and-therapeutic-advances-in-dermatomyositis,56,25191,1,1.html |
| _version_ | 1819078957262176256 |
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| author | Dominik Samotij Justyna Szczęch Adam Reich |
| author_facet | Dominik Samotij Justyna Szczęch Adam Reich |
| author_sort | Dominik Samotij |
| collection | DOAJ |
| description | Dermatomyositis (DM) is one of the so-called idiopathic inflammatory myopathies (IIM). Dermatomyositis is an autoimmune disorder characterized by the presence of cutaneous lesions and/or symptoms of muscle involvement with the following variants: the “classic” variant of DM, juvenile DM, paraneoplastic DM, drug-induced DM and amyopathic DM. Dynamic discoveries of novel autoantibodies, including anti-TIF1, anti-NXP2, anti-SAE or anti-MDA5, related to certain DM variants, have been described in recent years. It seems that these antibodies will contribute to better recognition of DM and its particular variants, a better risk stratification for predicting internal organ involvement, and to a global improvement of treatment outcome. Corticosteroids remain the mainstay of DM therapy, but new immunomodulatory and immunosuppressive agents, including biologicals, resulted in a significant increase of the survival rate of DM patients. Here, we review the current literature data on DM with special emphasis on new trends in its diagnostics and treatment. |
| first_indexed | 2024-12-21T19:21:21Z |
| format | Article |
| id | doaj.art-f987d3820dce4988bb68176e47f5a969 |
| institution | Directory Open Access Journal |
| issn | 0033-2526 2084-9893 |
| language | English |
| last_indexed | 2024-12-21T19:21:21Z |
| publishDate | 2015-06-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Przegląd Dermatologiczny |
| spelling | doaj.art-f987d3820dce4988bb68176e47f5a9692022-12-21T18:52:57ZengTermedia Publishing HousePrzegląd Dermatologiczny0033-25262084-98932015-06-01102318319710.5114/dr.2015.5191925191Special papers Diagnostic and therapeutic advances in dermatomyositisDominik SamotijJustyna SzczęchAdam ReichDermatomyositis (DM) is one of the so-called idiopathic inflammatory myopathies (IIM). Dermatomyositis is an autoimmune disorder characterized by the presence of cutaneous lesions and/or symptoms of muscle involvement with the following variants: the “classic” variant of DM, juvenile DM, paraneoplastic DM, drug-induced DM and amyopathic DM. Dynamic discoveries of novel autoantibodies, including anti-TIF1, anti-NXP2, anti-SAE or anti-MDA5, related to certain DM variants, have been described in recent years. It seems that these antibodies will contribute to better recognition of DM and its particular variants, a better risk stratification for predicting internal organ involvement, and to a global improvement of treatment outcome. Corticosteroids remain the mainstay of DM therapy, but new immunomodulatory and immunosuppressive agents, including biologicals, resulted in a significant increase of the survival rate of DM patients. Here, we review the current literature data on DM with special emphasis on new trends in its diagnostics and treatment.http://www.termedia.pl/Special-papers-Diagnostic-and-therapeutic-advances-in-dermatomyositis,56,25191,1,1.htmldermatomyositis idiopathic inflammatory myopathies autoantibodies immunosuppressive agents paraneoplastic syndrome. |
| spellingShingle | Dominik Samotij Justyna Szczęch Adam Reich Special papers Diagnostic and therapeutic advances in dermatomyositis Przegląd Dermatologiczny dermatomyositis idiopathic inflammatory myopathies autoantibodies immunosuppressive agents paraneoplastic syndrome. |
| title | Special papers Diagnostic and therapeutic advances in dermatomyositis |
| title_full | Special papers Diagnostic and therapeutic advances in dermatomyositis |
| title_fullStr | Special papers Diagnostic and therapeutic advances in dermatomyositis |
| title_full_unstemmed | Special papers Diagnostic and therapeutic advances in dermatomyositis |
| title_short | Special papers Diagnostic and therapeutic advances in dermatomyositis |
| title_sort | special papers diagnostic and therapeutic advances in dermatomyositis |
| topic | dermatomyositis idiopathic inflammatory myopathies autoantibodies immunosuppressive agents paraneoplastic syndrome. |
| url | http://www.termedia.pl/Special-papers-Diagnostic-and-therapeutic-advances-in-dermatomyositis,56,25191,1,1.html |
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