Characteristics of Optic Disc and Visual Field Changes in Patients with Thyroid-Associated Orbitopathy and Open-Angle Glaucoma
This study aimed to characterize the changes in the visual field (VF) patterns and disc morphology of patients with thyroid-associated orbitopathy (TAO) and open-angle glaucoma (OAG). A retrospective review of the medical records at the Tri-Service General Hospital in Taiwan identified 396 eyes of 1...
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| Format: | Article |
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MDPI AG
2021-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/17/3839 |
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| author | Chih-Kang Hsu Hsin-Yu Yao Che-Min Lin Hsu-Chieh Chang Da-Wen Lu Yi-Hao Chen Ke-Hung Chien |
| author_facet | Chih-Kang Hsu Hsin-Yu Yao Che-Min Lin Hsu-Chieh Chang Da-Wen Lu Yi-Hao Chen Ke-Hung Chien |
| author_sort | Chih-Kang Hsu |
| collection | DOAJ |
| description | This study aimed to characterize the changes in the visual field (VF) patterns and disc morphology of patients with thyroid-associated orbitopathy (TAO) and open-angle glaucoma (OAG). A retrospective review of the medical records at the Tri-Service General Hospital in Taiwan identified 396 eyes of 198 patients with thyroid-associated glaucoma. A final follow-up of VF examination in 140 eyes revealed 114 eyes with VF defects, indicating disease progression. The characteristics of and changes in disc morphology, optical coherence tomography findings, and VF defects were statistically analyzed. The most common VF defects at the initial diagnosis and the end of the follow-up period were inferior partial arcuate (17%) and paracentral (15%) defects, respectively. The most common VF defect in patients with unspecific disc signs was an unspecific scotoma (13%). The most common optic disc feature was disc cupping (51%), followed by parapapillary atrophy (48%). The most frequent location of nerve fiber layer thinning was the inferotemporal region (48%). VF defects showed a significantly more pronounced progression in the non-nerve fiber bundle group than in the nerve fiber bundle group (<i>p</i> < 0.001). This study details the characteristics and progression of disc morphology and VF defects in patients with TAO and OAG. |
| first_indexed | 2024-03-10T08:10:19Z |
| format | Article |
| id | doaj.art-f988da663ea340c5a2745631b9b22d6f |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T08:10:19Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-f988da663ea340c5a2745631b9b22d6f2023-11-22T10:48:13ZengMDPI AGJournal of Clinical Medicine2077-03832021-08-011017383910.3390/jcm10173839Characteristics of Optic Disc and Visual Field Changes in Patients with Thyroid-Associated Orbitopathy and Open-Angle GlaucomaChih-Kang Hsu0Hsin-Yu Yao1Che-Min Lin2Hsu-Chieh Chang3Da-Wen Lu4Yi-Hao Chen5Ke-Hung Chien6Department of Ophthalmology, Songshan Branch, Tri-Service General Hospital, Songshan 10581, TaiwanHau-Ming Eye Clinic Center, New Taipei City 22158, TaiwanDepartment of Ophthalmology, Taichung Armed Forces General Hospital, Taichung City 41152, TaiwanDepartment of Nursing, Tri-Service General Hospital & National Defense Medical Center, Taipei 11490, TaiwanDepartment of Ophthalmology, Tri-Service General Hospital & National Defense Medical Center, Taipei 11490, TaiwanDepartment of Ophthalmology, Tri-Service General Hospital & National Defense Medical Center, Taipei 11490, TaiwanDepartment of Ophthalmology, Tri-Service General Hospital & National Defense Medical Center, Taipei 11490, TaiwanThis study aimed to characterize the changes in the visual field (VF) patterns and disc morphology of patients with thyroid-associated orbitopathy (TAO) and open-angle glaucoma (OAG). A retrospective review of the medical records at the Tri-Service General Hospital in Taiwan identified 396 eyes of 198 patients with thyroid-associated glaucoma. A final follow-up of VF examination in 140 eyes revealed 114 eyes with VF defects, indicating disease progression. The characteristics of and changes in disc morphology, optical coherence tomography findings, and VF defects were statistically analyzed. The most common VF defects at the initial diagnosis and the end of the follow-up period were inferior partial arcuate (17%) and paracentral (15%) defects, respectively. The most common VF defect in patients with unspecific disc signs was an unspecific scotoma (13%). The most common optic disc feature was disc cupping (51%), followed by parapapillary atrophy (48%). The most frequent location of nerve fiber layer thinning was the inferotemporal region (48%). VF defects showed a significantly more pronounced progression in the non-nerve fiber bundle group than in the nerve fiber bundle group (<i>p</i> < 0.001). This study details the characteristics and progression of disc morphology and VF defects in patients with TAO and OAG.https://www.mdpi.com/2077-0383/10/17/3839hyperthyroidismopen-angle glaucomathyroid eye diseasethyroid-associated orbitopathy |
| spellingShingle | Chih-Kang Hsu Hsin-Yu Yao Che-Min Lin Hsu-Chieh Chang Da-Wen Lu Yi-Hao Chen Ke-Hung Chien Characteristics of Optic Disc and Visual Field Changes in Patients with Thyroid-Associated Orbitopathy and Open-Angle Glaucoma Journal of Clinical Medicine hyperthyroidism open-angle glaucoma thyroid eye disease thyroid-associated orbitopathy |
| title | Characteristics of Optic Disc and Visual Field Changes in Patients with Thyroid-Associated Orbitopathy and Open-Angle Glaucoma |
| title_full | Characteristics of Optic Disc and Visual Field Changes in Patients with Thyroid-Associated Orbitopathy and Open-Angle Glaucoma |
| title_fullStr | Characteristics of Optic Disc and Visual Field Changes in Patients with Thyroid-Associated Orbitopathy and Open-Angle Glaucoma |
| title_full_unstemmed | Characteristics of Optic Disc and Visual Field Changes in Patients with Thyroid-Associated Orbitopathy and Open-Angle Glaucoma |
| title_short | Characteristics of Optic Disc and Visual Field Changes in Patients with Thyroid-Associated Orbitopathy and Open-Angle Glaucoma |
| title_sort | characteristics of optic disc and visual field changes in patients with thyroid associated orbitopathy and open angle glaucoma |
| topic | hyperthyroidism open-angle glaucoma thyroid eye disease thyroid-associated orbitopathy |
| url | https://www.mdpi.com/2077-0383/10/17/3839 |
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