Correlation of NICU anthropometry in extremely preterm infants with brain development and language scores at early school age
Abstract Growth in preterm infants in the neonatal intensive care unit (NICU) is associated with increased global and regional brain volumes at term, and increased postnatal linear growth is associated with higher language scores at age 2. It is unknown whether these relationships persist to school...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-42281-0 |
| _version_ | 1797452756141735936 |
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| author | Ting Ting Fu Maria E. Barnes-Davis Hisako Fujiwara Alonzo T. Folger Stephanie L. Merhar Darren S. Kadis Brenda B. Poindexter Nehal A. Parikh |
| author_facet | Ting Ting Fu Maria E. Barnes-Davis Hisako Fujiwara Alonzo T. Folger Stephanie L. Merhar Darren S. Kadis Brenda B. Poindexter Nehal A. Parikh |
| author_sort | Ting Ting Fu |
| collection | DOAJ |
| description | Abstract Growth in preterm infants in the neonatal intensive care unit (NICU) is associated with increased global and regional brain volumes at term, and increased postnatal linear growth is associated with higher language scores at age 2. It is unknown whether these relationships persist to school age or if an association between growth and cortical metrics exists. Using regression analyses, we investigated relationships between the growth of 42 children born extremely preterm (< 28 weeks gestation) from their NICU hospitalization, standardized neurodevelopmental/language assessments at 2 and 4–6 years, and multiple neuroimaging biomarkers obtained from T1-weighted images at 4–6 years. We found length at birth and 36 weeks post-menstrual age had positive associations with language scores at 2 years in multivariable linear regression. No growth metric correlated with 4–6 year assessments. Weight and head circumference at 36 weeks post-menstrual age positively correlated with total brain volume and negatively with global cortical thickness at 4–6 years of age. Head circumference relationships remained significant after adjusting for age, sex, and socioeconomic status. Right temporal cortical thickness was related to receptive language at 4–6 years in the multivariable model. Results suggest growth in the NICU may have lasting effects on brain development in extremely preterm children. |
| first_indexed | 2024-03-09T15:13:15Z |
| format | Article |
| id | doaj.art-f9897a1786fc4bef8695b1467caa0011 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:13:15Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-f9897a1786fc4bef8695b1467caa00112023-11-26T13:16:54ZengNature PortfolioScientific Reports2045-23222023-09-0113111010.1038/s41598-023-42281-0Correlation of NICU anthropometry in extremely preterm infants with brain development and language scores at early school ageTing Ting Fu0Maria E. Barnes-Davis1Hisako Fujiwara2Alonzo T. Folger3Stephanie L. Merhar4Darren S. Kadis5Brenda B. Poindexter6Nehal A. Parikh7Division of Neonatology, Perinatal Institute, Cincinnati Children’s Hospital Medical CenterDivision of Neonatology, Perinatal Institute, Cincinnati Children’s Hospital Medical CenterDepartment of Pediatrics, University of Cincinnati College of MedicineDepartment of Pediatrics, University of Cincinnati College of MedicineDivision of Neonatology, Perinatal Institute, Cincinnati Children’s Hospital Medical CenterNeurosciences and Mental Health, Hospital for Sick ChildrenDivision of Neonatology, Department of Pediatrics, Emory University School of Medicine and Children’s Healthcare of AtlantaDivision of Neonatology, Perinatal Institute, Cincinnati Children’s Hospital Medical CenterAbstract Growth in preterm infants in the neonatal intensive care unit (NICU) is associated with increased global and regional brain volumes at term, and increased postnatal linear growth is associated with higher language scores at age 2. It is unknown whether these relationships persist to school age or if an association between growth and cortical metrics exists. Using regression analyses, we investigated relationships between the growth of 42 children born extremely preterm (< 28 weeks gestation) from their NICU hospitalization, standardized neurodevelopmental/language assessments at 2 and 4–6 years, and multiple neuroimaging biomarkers obtained from T1-weighted images at 4–6 years. We found length at birth and 36 weeks post-menstrual age had positive associations with language scores at 2 years in multivariable linear regression. No growth metric correlated with 4–6 year assessments. Weight and head circumference at 36 weeks post-menstrual age positively correlated with total brain volume and negatively with global cortical thickness at 4–6 years of age. Head circumference relationships remained significant after adjusting for age, sex, and socioeconomic status. Right temporal cortical thickness was related to receptive language at 4–6 years in the multivariable model. Results suggest growth in the NICU may have lasting effects on brain development in extremely preterm children.https://doi.org/10.1038/s41598-023-42281-0 |
| spellingShingle | Ting Ting Fu Maria E. Barnes-Davis Hisako Fujiwara Alonzo T. Folger Stephanie L. Merhar Darren S. Kadis Brenda B. Poindexter Nehal A. Parikh Correlation of NICU anthropometry in extremely preterm infants with brain development and language scores at early school age Scientific Reports |
| title | Correlation of NICU anthropometry in extremely preterm infants with brain development and language scores at early school age |
| title_full | Correlation of NICU anthropometry in extremely preterm infants with brain development and language scores at early school age |
| title_fullStr | Correlation of NICU anthropometry in extremely preterm infants with brain development and language scores at early school age |
| title_full_unstemmed | Correlation of NICU anthropometry in extremely preterm infants with brain development and language scores at early school age |
| title_short | Correlation of NICU anthropometry in extremely preterm infants with brain development and language scores at early school age |
| title_sort | correlation of nicu anthropometry in extremely preterm infants with brain development and language scores at early school age |
| url | https://doi.org/10.1038/s41598-023-42281-0 |
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