Viruses utilize ubiquitination systems to escape TLR/RLR-mediated innate immunity
When the viruses invade the body, they will be recognized by the host pattern recognition receptors (PRRs) such as Toll like receptor (TLR) or retinoic acid-induced gene-I like receptor (RLR), thus causing the activation of downstream antiviral signals to resist the virus invasion. The cross action...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1065211/full |
| _version_ | 1811186585174016000 |
|---|---|
| author | Shanzhi Huang Shanzhi Huang Anchun Cheng Anchun Cheng Anchun Cheng Mingshu Wang Mingshu Wang Mingshu Wang Zhongqiong Yin Juan Huang Juan Huang Juan Huang Renyong Jia Renyong Jia Renyong Jia |
| author_facet | Shanzhi Huang Shanzhi Huang Anchun Cheng Anchun Cheng Anchun Cheng Mingshu Wang Mingshu Wang Mingshu Wang Zhongqiong Yin Juan Huang Juan Huang Juan Huang Renyong Jia Renyong Jia Renyong Jia |
| author_sort | Shanzhi Huang |
| collection | DOAJ |
| description | When the viruses invade the body, they will be recognized by the host pattern recognition receptors (PRRs) such as Toll like receptor (TLR) or retinoic acid-induced gene-I like receptor (RLR), thus causing the activation of downstream antiviral signals to resist the virus invasion. The cross action between ubiquitination and proteins in these signal cascades enhances the antiviral signal. On the contrary, more and more viruses have also been found to use the ubiquitination system to inhibit TLR/RLR mediated innate immunity. Therefore, this review summarizes how the ubiquitination system plays a regulatory role in TLR/RLR mediated innate immunity, and how viruses use the ubiquitination system to complete immune escape. |
| first_indexed | 2024-04-11T13:48:59Z |
| format | Article |
| id | doaj.art-f989c73d1df148f7b1d182695d86dcdd |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T13:48:59Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f989c73d1df148f7b1d182695d86dcdd2022-12-22T04:20:53ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-11-011310.3389/fimmu.2022.10652111065211Viruses utilize ubiquitination systems to escape TLR/RLR-mediated innate immunityShanzhi Huang0Shanzhi Huang1Anchun Cheng2Anchun Cheng3Anchun Cheng4Mingshu Wang5Mingshu Wang6Mingshu Wang7Zhongqiong Yin8Juan Huang9Juan Huang10Juan Huang11Renyong Jia12Renyong Jia13Renyong Jia14Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaAvian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaAvian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaAvian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaAvian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaInstitute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaKey Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, ChinaWhen the viruses invade the body, they will be recognized by the host pattern recognition receptors (PRRs) such as Toll like receptor (TLR) or retinoic acid-induced gene-I like receptor (RLR), thus causing the activation of downstream antiviral signals to resist the virus invasion. The cross action between ubiquitination and proteins in these signal cascades enhances the antiviral signal. On the contrary, more and more viruses have also been found to use the ubiquitination system to inhibit TLR/RLR mediated innate immunity. Therefore, this review summarizes how the ubiquitination system plays a regulatory role in TLR/RLR mediated innate immunity, and how viruses use the ubiquitination system to complete immune escape.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1065211/fullubiquitinationvirusinnate immuneE3 ubiquitin ligaseTLRRLR |
| spellingShingle | Shanzhi Huang Shanzhi Huang Anchun Cheng Anchun Cheng Anchun Cheng Mingshu Wang Mingshu Wang Mingshu Wang Zhongqiong Yin Juan Huang Juan Huang Juan Huang Renyong Jia Renyong Jia Renyong Jia Viruses utilize ubiquitination systems to escape TLR/RLR-mediated innate immunity Frontiers in Immunology ubiquitination virus innate immune E3 ubiquitin ligase TLR RLR |
| title | Viruses utilize ubiquitination systems to escape TLR/RLR-mediated innate immunity |
| title_full | Viruses utilize ubiquitination systems to escape TLR/RLR-mediated innate immunity |
| title_fullStr | Viruses utilize ubiquitination systems to escape TLR/RLR-mediated innate immunity |
| title_full_unstemmed | Viruses utilize ubiquitination systems to escape TLR/RLR-mediated innate immunity |
| title_short | Viruses utilize ubiquitination systems to escape TLR/RLR-mediated innate immunity |
| title_sort | viruses utilize ubiquitination systems to escape tlr rlr mediated innate immunity |
| topic | ubiquitination virus innate immune E3 ubiquitin ligase TLR RLR |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1065211/full |
| work_keys_str_mv | AT shanzhihuang virusesutilizeubiquitinationsystemstoescapetlrrlrmediatedinnateimmunity AT shanzhihuang virusesutilizeubiquitinationsystemstoescapetlrrlrmediatedinnateimmunity AT anchuncheng virusesutilizeubiquitinationsystemstoescapetlrrlrmediatedinnateimmunity AT anchuncheng virusesutilizeubiquitinationsystemstoescapetlrrlrmediatedinnateimmunity AT anchuncheng virusesutilizeubiquitinationsystemstoescapetlrrlrmediatedinnateimmunity AT mingshuwang virusesutilizeubiquitinationsystemstoescapetlrrlrmediatedinnateimmunity AT mingshuwang virusesutilizeubiquitinationsystemstoescapetlrrlrmediatedinnateimmunity AT mingshuwang virusesutilizeubiquitinationsystemstoescapetlrrlrmediatedinnateimmunity AT zhongqiongyin virusesutilizeubiquitinationsystemstoescapetlrrlrmediatedinnateimmunity AT juanhuang virusesutilizeubiquitinationsystemstoescapetlrrlrmediatedinnateimmunity AT juanhuang virusesutilizeubiquitinationsystemstoescapetlrrlrmediatedinnateimmunity AT juanhuang virusesutilizeubiquitinationsystemstoescapetlrrlrmediatedinnateimmunity AT renyongjia virusesutilizeubiquitinationsystemstoescapetlrrlrmediatedinnateimmunity AT renyongjia virusesutilizeubiquitinationsystemstoescapetlrrlrmediatedinnateimmunity AT renyongjia virusesutilizeubiquitinationsystemstoescapetlrrlrmediatedinnateimmunity |