Phase separation-mediated biomolecular condensates and their relationship to tumor
Abstract Phase separation is a cellular phenomenon where macromolecules aggregate or segregate, giving rise to biomolecular condensates resembling "droplets" and forming distinct, membrane-free compartments. This process is pervasive in biological cells, contributing to various essential c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-024-01518-9 |
| _version_ | 1797273855675334656 |
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| author | Xi Wang Jiameng Liu Chaoming Mao Yufei Mao |
| author_facet | Xi Wang Jiameng Liu Chaoming Mao Yufei Mao |
| author_sort | Xi Wang |
| collection | DOAJ |
| description | Abstract Phase separation is a cellular phenomenon where macromolecules aggregate or segregate, giving rise to biomolecular condensates resembling "droplets" and forming distinct, membrane-free compartments. This process is pervasive in biological cells, contributing to various essential cellular functions. However, when phase separation goes awry, leading to abnormal molecular aggregation, it can become a driving factor in the development of diseases, including tumor. Recent investigations have unveiled the intricate connection between dysregulated phase separation and tumor pathogenesis, highlighting its potential as a novel therapeutic target. This article provides an overview of recent phase separation research, with a particular emphasis on its role in tumor, its therapeutic implications, and outlines avenues for further exploration in this intriguing field. |
| first_indexed | 2024-03-07T14:50:07Z |
| format | Article |
| id | doaj.art-f98a0d1a164e4ed488deb5d9df5d0265 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-03-07T14:50:07Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-f98a0d1a164e4ed488deb5d9df5d02652024-03-05T19:47:19ZengBMCCell Communication and Signaling1478-811X2024-02-0122112010.1186/s12964-024-01518-9Phase separation-mediated biomolecular condensates and their relationship to tumorXi Wang0Jiameng Liu1Chaoming Mao2Yufei Mao3Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu UniversityDepartment of Nuclear Medicine, The Affiliated Hospital of Jiangsu UniversityDepartment of Nuclear Medicine, The Affiliated Hospital of Jiangsu UniversityDepartment of Ultrasound Medicine, The Affiliated Hospital of Jiangsu UniversityAbstract Phase separation is a cellular phenomenon where macromolecules aggregate or segregate, giving rise to biomolecular condensates resembling "droplets" and forming distinct, membrane-free compartments. This process is pervasive in biological cells, contributing to various essential cellular functions. However, when phase separation goes awry, leading to abnormal molecular aggregation, it can become a driving factor in the development of diseases, including tumor. Recent investigations have unveiled the intricate connection between dysregulated phase separation and tumor pathogenesis, highlighting its potential as a novel therapeutic target. This article provides an overview of recent phase separation research, with a particular emphasis on its role in tumor, its therapeutic implications, and outlines avenues for further exploration in this intriguing field.https://doi.org/10.1186/s12964-024-01518-9Phase separationBiomolecular condensatesTumorTherapeutic targets |
| spellingShingle | Xi Wang Jiameng Liu Chaoming Mao Yufei Mao Phase separation-mediated biomolecular condensates and their relationship to tumor Cell Communication and Signaling Phase separation Biomolecular condensates Tumor Therapeutic targets |
| title | Phase separation-mediated biomolecular condensates and their relationship to tumor |
| title_full | Phase separation-mediated biomolecular condensates and their relationship to tumor |
| title_fullStr | Phase separation-mediated biomolecular condensates and their relationship to tumor |
| title_full_unstemmed | Phase separation-mediated biomolecular condensates and their relationship to tumor |
| title_short | Phase separation-mediated biomolecular condensates and their relationship to tumor |
| title_sort | phase separation mediated biomolecular condensates and their relationship to tumor |
| topic | Phase separation Biomolecular condensates Tumor Therapeutic targets |
| url | https://doi.org/10.1186/s12964-024-01518-9 |
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