Performance of cone-beam computed tomography (CBCT) in comparison to conventional computed tomography (CT) and magnetic resonance imaging (MRI) for the detection of bone invasion in oral squamous cell cancer (OSCC): a prospective study
Abstract Background Oral squamous carcinoma (OSCC) is often diagnosed at late stages and bone erosion or invasion of the jawbone is frequently present. Computed tomography (CT) and magnetic resonance imaging (MRI) are known to have high diagnostic sensitivities, specificities, and accuracies in dete...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | BMC Oral Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12903-024-04057-4 |
| _version_ | 1797259046887096320 |
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| author | Anton Straub Christian Linz Constantin Lapa Stefan Hartmann Alexander C. Kübler Urs D. A. Müller-Richter Julian Faber Thorsten Bley Joachim Brumberg Olivia Kertels Roman C. Brands |
| author_facet | Anton Straub Christian Linz Constantin Lapa Stefan Hartmann Alexander C. Kübler Urs D. A. Müller-Richter Julian Faber Thorsten Bley Joachim Brumberg Olivia Kertels Roman C. Brands |
| author_sort | Anton Straub |
| collection | DOAJ |
| description | Abstract Background Oral squamous carcinoma (OSCC) is often diagnosed at late stages and bone erosion or invasion of the jawbone is frequently present. Computed tomography (CT) and magnetic resonance imaging (MRI) are known to have high diagnostic sensitivities, specificities, and accuracies in detecting these bone affections in patients suffering from OSCC. To date, the existing data regarding the impact of cone-beam computed tomography (CBCT) have been weak. Therefore, this study aimed to investigate whether CBCT is a suitable tool to detect bone erosion or invasion in patients with OSCC. Methods We investigated in a prospective trial the impact of CBCT in the diagnosis of bone erosion or invasion in patients with OSCC who underwent surgery. Every participant received a CBCT, CT, and MRI scan during staging. Imaging modalities were evaluated by two specialists in oral and maxillofacial surgery (CBCT) and two specialists in radiology (CT and MRI) in a blinded way, to determine whether a bone affection was present or not. Reporting used the following 3-point system: no bony destruction (“0”), cortical bone erosion (“1”), or medullary bone invasion (“2”). Histological examination or a follow-up served to calculate the sensitivities, specificities, and accuracies of the imaging modalities. Results Our results revealed high diagnostic sensitivities (95.6%, 84.4%, and 88.9%), specificities (87.0%, 91.7%, and 91.7%), and accuracies (89.5%, 89.5%, and 90.8%) for CBCT, CT, and MRI. A pairwise comparison found no statistical difference between CBCT, CT, and MRI. Conclusion Our data support the routine use of CBCT in the diagnosis of bone erosion and invasion in patients with OSCC as diagnostic accuracy is equal to CT and MRI, the procedure is cost-effective, and it can be performed during initial contact with the patient. |
| first_indexed | 2024-04-24T23:03:12Z |
| format | Article |
| id | doaj.art-f98bda13db944264a1f725ac615ab0b1 |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-04-24T23:03:12Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-f98bda13db944264a1f725ac615ab0b12024-03-17T12:40:27ZengBMCBMC Oral Health1472-68312024-03-012411910.1186/s12903-024-04057-4Performance of cone-beam computed tomography (CBCT) in comparison to conventional computed tomography (CT) and magnetic resonance imaging (MRI) for the detection of bone invasion in oral squamous cell cancer (OSCC): a prospective studyAnton Straub0Christian Linz1Constantin Lapa2Stefan Hartmann3Alexander C. Kübler4Urs D. A. Müller-Richter5Julian Faber6Thorsten Bley7Joachim Brumberg8Olivia Kertels9Roman C. Brands10Department of Oral and Maxillofacial Plastic Surgery, University Hospital WürzburgDepartment of Oral, Maxillofacial and Plastic Surgery, University of Köln, Faculty of Medicine and University Hospital KölnNuclear Medicine, Faculty of Medicine, University of AugsburgDepartment of Oral and Maxillofacial Plastic Surgery, University Hospital WürzburgDepartment of Oral and Maxillofacial Plastic Surgery, University Hospital WürzburgDepartment of Oral and Maxillofacial Plastic Surgery, University Hospital WürzburgDepartment of Oral, Maxillofacial and Plastic Surgery, University of Köln, Faculty of Medicine and University Hospital KölnDepartment of Diagnostic and Interventional Radiology, University Hospital WürzburgDepartment of Nuclear Medicine, Medical Center, Faculty of Medicine, University of Freiburg, University of FreiburgDepartment of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technical University of MünchenDepartment of Oral and Maxillofacial Plastic Surgery, University Hospital WürzburgAbstract Background Oral squamous carcinoma (OSCC) is often diagnosed at late stages and bone erosion or invasion of the jawbone is frequently present. Computed tomography (CT) and magnetic resonance imaging (MRI) are known to have high diagnostic sensitivities, specificities, and accuracies in detecting these bone affections in patients suffering from OSCC. To date, the existing data regarding the impact of cone-beam computed tomography (CBCT) have been weak. Therefore, this study aimed to investigate whether CBCT is a suitable tool to detect bone erosion or invasion in patients with OSCC. Methods We investigated in a prospective trial the impact of CBCT in the diagnosis of bone erosion or invasion in patients with OSCC who underwent surgery. Every participant received a CBCT, CT, and MRI scan during staging. Imaging modalities were evaluated by two specialists in oral and maxillofacial surgery (CBCT) and two specialists in radiology (CT and MRI) in a blinded way, to determine whether a bone affection was present or not. Reporting used the following 3-point system: no bony destruction (“0”), cortical bone erosion (“1”), or medullary bone invasion (“2”). Histological examination or a follow-up served to calculate the sensitivities, specificities, and accuracies of the imaging modalities. Results Our results revealed high diagnostic sensitivities (95.6%, 84.4%, and 88.9%), specificities (87.0%, 91.7%, and 91.7%), and accuracies (89.5%, 89.5%, and 90.8%) for CBCT, CT, and MRI. A pairwise comparison found no statistical difference between CBCT, CT, and MRI. Conclusion Our data support the routine use of CBCT in the diagnosis of bone erosion and invasion in patients with OSCC as diagnostic accuracy is equal to CT and MRI, the procedure is cost-effective, and it can be performed during initial contact with the patient.https://doi.org/10.1186/s12903-024-04057-4Bone invasionBone resectionComputed tomographyCone-beam computed tomographyHead and neck cancerMandibulectomy |
| spellingShingle | Anton Straub Christian Linz Constantin Lapa Stefan Hartmann Alexander C. Kübler Urs D. A. Müller-Richter Julian Faber Thorsten Bley Joachim Brumberg Olivia Kertels Roman C. Brands Performance of cone-beam computed tomography (CBCT) in comparison to conventional computed tomography (CT) and magnetic resonance imaging (MRI) for the detection of bone invasion in oral squamous cell cancer (OSCC): a prospective study BMC Oral Health Bone invasion Bone resection Computed tomography Cone-beam computed tomography Head and neck cancer Mandibulectomy |
| title | Performance of cone-beam computed tomography (CBCT) in comparison to conventional computed tomography (CT) and magnetic resonance imaging (MRI) for the detection of bone invasion in oral squamous cell cancer (OSCC): a prospective study |
| title_full | Performance of cone-beam computed tomography (CBCT) in comparison to conventional computed tomography (CT) and magnetic resonance imaging (MRI) for the detection of bone invasion in oral squamous cell cancer (OSCC): a prospective study |
| title_fullStr | Performance of cone-beam computed tomography (CBCT) in comparison to conventional computed tomography (CT) and magnetic resonance imaging (MRI) for the detection of bone invasion in oral squamous cell cancer (OSCC): a prospective study |
| title_full_unstemmed | Performance of cone-beam computed tomography (CBCT) in comparison to conventional computed tomography (CT) and magnetic resonance imaging (MRI) for the detection of bone invasion in oral squamous cell cancer (OSCC): a prospective study |
| title_short | Performance of cone-beam computed tomography (CBCT) in comparison to conventional computed tomography (CT) and magnetic resonance imaging (MRI) for the detection of bone invasion in oral squamous cell cancer (OSCC): a prospective study |
| title_sort | performance of cone beam computed tomography cbct in comparison to conventional computed tomography ct and magnetic resonance imaging mri for the detection of bone invasion in oral squamous cell cancer oscc a prospective study |
| topic | Bone invasion Bone resection Computed tomography Cone-beam computed tomography Head and neck cancer Mandibulectomy |
| url | https://doi.org/10.1186/s12903-024-04057-4 |
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