The Effectiveness of Compression Garments for Reducing Pain in Non-Vascular Ehlers-Danlos Syndromes: A Prospective Observational Cohort Study
Patients with Ehlers-Danlos Syndrome (EDS) frequently suffer from severe chronic pain. We carried out an observational cohort study to assess the effectiveness of compression garments (CGs) for reducing this pain. Patients with non-vascular EDS were given custom-made Cerecare<sup>®</sup>...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-06-01
|
| Series: | Healthcare |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9032/11/13/1862 |
| _version_ | 1797591740375367680 |
|---|---|
| author | Karelle Benistan Bénédicte Pontier Catherine Leblond Ophélie Flageul Gwenvael Le Guicher Michel Enjalbert Fabrice Gillas |
| author_facet | Karelle Benistan Bénédicte Pontier Catherine Leblond Ophélie Flageul Gwenvael Le Guicher Michel Enjalbert Fabrice Gillas |
| author_sort | Karelle Benistan |
| collection | DOAJ |
| description | Patients with Ehlers-Danlos Syndrome (EDS) frequently suffer from severe chronic pain. We carried out an observational cohort study to assess the effectiveness of compression garments (CGs) for reducing this pain. Patients with non-vascular EDS were given custom-made Cerecare<sup>®</sup> CGs during a visit to a specialist clinic (visit V0). They were followed up over 2 years with visits every 6 months (V1–V4). At each visit, pain was assessed for the joints treated with CGs using a visual analogue scale (VAS; 0–100 mm). Additional measures were obtained to assess neuropathic pain (painDETECT questionnaire), proprioception/balance (Berg Balance Scale), and functional independence, amongst others. Data were analyzed for 67 patients with EDS (hypermobile: 91%; classical: 6%; kyphoscoliotic: 3%). For the most painful joint, the mean VAS rating was 71.5 ± 22.8 mm at V0; this decreased to 53.5 ± 25.5 mm at V1 and 45.7 ± 29 mm at V4 (<i>t</i>-tests: <i>p</i> < 0.0001). From V0 to V4, improvements were also seen for pain at the other joints, neuropathic pain, functional independence, proprioception/balance, and the incidence of sprains and dislocations/subluxations, although not all comparisons were statistically significant (<i>p</i> < 0.05 level). These results indicate that CGs may effectively reduce the pain and joint instability in non-vascular EDS patients. |
| first_indexed | 2024-03-11T01:41:37Z |
| format | Article |
| id | doaj.art-f98c107f02fc45a58d7338d57261a406 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-11T01:41:37Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-f98c107f02fc45a58d7338d57261a4062023-11-18T16:36:09ZengMDPI AGHealthcare2227-90322023-06-011113186210.3390/healthcare11131862The Effectiveness of Compression Garments for Reducing Pain in Non-Vascular Ehlers-Danlos Syndromes: A Prospective Observational Cohort StudyKarelle Benistan0Bénédicte Pontier1Catherine Leblond2Ophélie Flageul3Gwenvael Le Guicher4Michel Enjalbert5Fabrice Gillas6Reference Center for Ehlers-Danlos Syndromes, Raymond Poincaré Hospital, 92380 Garches, FranceGénétique Médicale, Estaing University Hospital, 63100 Clermont-Ferrand, FranceBouffard-Vercelli Center, USSAP, 66000 Perpignan, FranceSLBPharma, 35000 Rennes, FranceSLBPharma, 35000 Rennes, FranceBouffard-Vercelli Center, USSAP, 66000 Perpignan, FranceReference Center for Ehlers-Danlos Syndromes, Raymond Poincaré Hospital, 92380 Garches, FrancePatients with Ehlers-Danlos Syndrome (EDS) frequently suffer from severe chronic pain. We carried out an observational cohort study to assess the effectiveness of compression garments (CGs) for reducing this pain. Patients with non-vascular EDS were given custom-made Cerecare<sup>®</sup> CGs during a visit to a specialist clinic (visit V0). They were followed up over 2 years with visits every 6 months (V1–V4). At each visit, pain was assessed for the joints treated with CGs using a visual analogue scale (VAS; 0–100 mm). Additional measures were obtained to assess neuropathic pain (painDETECT questionnaire), proprioception/balance (Berg Balance Scale), and functional independence, amongst others. Data were analyzed for 67 patients with EDS (hypermobile: 91%; classical: 6%; kyphoscoliotic: 3%). For the most painful joint, the mean VAS rating was 71.5 ± 22.8 mm at V0; this decreased to 53.5 ± 25.5 mm at V1 and 45.7 ± 29 mm at V4 (<i>t</i>-tests: <i>p</i> < 0.0001). From V0 to V4, improvements were also seen for pain at the other joints, neuropathic pain, functional independence, proprioception/balance, and the incidence of sprains and dislocations/subluxations, although not all comparisons were statistically significant (<i>p</i> < 0.05 level). These results indicate that CGs may effectively reduce the pain and joint instability in non-vascular EDS patients.https://www.mdpi.com/2227-9032/11/13/1862Ehlers-Danlos syndromescompression garmentsjoint hypermobilitypain therapyorthosessprains |
| spellingShingle | Karelle Benistan Bénédicte Pontier Catherine Leblond Ophélie Flageul Gwenvael Le Guicher Michel Enjalbert Fabrice Gillas The Effectiveness of Compression Garments for Reducing Pain in Non-Vascular Ehlers-Danlos Syndromes: A Prospective Observational Cohort Study Healthcare Ehlers-Danlos syndromes compression garments joint hypermobility pain therapy orthoses sprains |
| title | The Effectiveness of Compression Garments for Reducing Pain in Non-Vascular Ehlers-Danlos Syndromes: A Prospective Observational Cohort Study |
| title_full | The Effectiveness of Compression Garments for Reducing Pain in Non-Vascular Ehlers-Danlos Syndromes: A Prospective Observational Cohort Study |
| title_fullStr | The Effectiveness of Compression Garments for Reducing Pain in Non-Vascular Ehlers-Danlos Syndromes: A Prospective Observational Cohort Study |
| title_full_unstemmed | The Effectiveness of Compression Garments for Reducing Pain in Non-Vascular Ehlers-Danlos Syndromes: A Prospective Observational Cohort Study |
| title_short | The Effectiveness of Compression Garments for Reducing Pain in Non-Vascular Ehlers-Danlos Syndromes: A Prospective Observational Cohort Study |
| title_sort | effectiveness of compression garments for reducing pain in non vascular ehlers danlos syndromes a prospective observational cohort study |
| topic | Ehlers-Danlos syndromes compression garments joint hypermobility pain therapy orthoses sprains |
| url | https://www.mdpi.com/2227-9032/11/13/1862 |
| work_keys_str_mv | AT karellebenistan theeffectivenessofcompressiongarmentsforreducingpaininnonvascularehlersdanlossyndromesaprospectiveobservationalcohortstudy AT benedictepontier theeffectivenessofcompressiongarmentsforreducingpaininnonvascularehlersdanlossyndromesaprospectiveobservationalcohortstudy AT catherineleblond theeffectivenessofcompressiongarmentsforreducingpaininnonvascularehlersdanlossyndromesaprospectiveobservationalcohortstudy AT ophelieflageul theeffectivenessofcompressiongarmentsforreducingpaininnonvascularehlersdanlossyndromesaprospectiveobservationalcohortstudy AT gwenvaelleguicher theeffectivenessofcompressiongarmentsforreducingpaininnonvascularehlersdanlossyndromesaprospectiveobservationalcohortstudy AT michelenjalbert theeffectivenessofcompressiongarmentsforreducingpaininnonvascularehlersdanlossyndromesaprospectiveobservationalcohortstudy AT fabricegillas theeffectivenessofcompressiongarmentsforreducingpaininnonvascularehlersdanlossyndromesaprospectiveobservationalcohortstudy AT karellebenistan effectivenessofcompressiongarmentsforreducingpaininnonvascularehlersdanlossyndromesaprospectiveobservationalcohortstudy AT benedictepontier effectivenessofcompressiongarmentsforreducingpaininnonvascularehlersdanlossyndromesaprospectiveobservationalcohortstudy AT catherineleblond effectivenessofcompressiongarmentsforreducingpaininnonvascularehlersdanlossyndromesaprospectiveobservationalcohortstudy AT ophelieflageul effectivenessofcompressiongarmentsforreducingpaininnonvascularehlersdanlossyndromesaprospectiveobservationalcohortstudy AT gwenvaelleguicher effectivenessofcompressiongarmentsforreducingpaininnonvascularehlersdanlossyndromesaprospectiveobservationalcohortstudy AT michelenjalbert effectivenessofcompressiongarmentsforreducingpaininnonvascularehlersdanlossyndromesaprospectiveobservationalcohortstudy AT fabricegillas effectivenessofcompressiongarmentsforreducingpaininnonvascularehlersdanlossyndromesaprospectiveobservationalcohortstudy |