In vivo observation of a stomach road or ‘Magenstrasse’ for gastric emptying using MRI imaging in healthy humans
Summary: The presence of a ‘magenstrasse’, a central ‘stomach road’ for flow and mixing of foods and drinks in the stomach had been predicted from hydrodynamic modelling. Here a magnetic resonance imaging (MRI) tagging technique was used to gain novel insights on the intragastric motion of breakfast...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-10-01
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| Series: | Clinical Nutrition Open Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667268523000360 |
| _version_ | 1797659949856194560 |
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| author | Fahad Almutairi Jaber Alyami Susan Pritchard Wala Alsharef Robin C. Spiller Penny A. Gowland Moira A. Taylor Luca Marciani Caroline L. Hoad |
| author_facet | Fahad Almutairi Jaber Alyami Susan Pritchard Wala Alsharef Robin C. Spiller Penny A. Gowland Moira A. Taylor Luca Marciani Caroline L. Hoad |
| author_sort | Fahad Almutairi |
| collection | DOAJ |
| description | Summary: The presence of a ‘magenstrasse’, a central ‘stomach road’ for flow and mixing of foods and drinks in the stomach had been predicted from hydrodynamic modelling. Here a magnetic resonance imaging (MRI) tagging technique was used to gain novel insights on the intragastric motion of breakfast porridges in 17 healthy humans. They consumed two similar breakfast porridge meals on separate days and tagging images with two different delay times were acquired 15 and 45 minutes postprandially, generating 128 data sets. Motion of the gastric contents was assessed by coefficient of variation (CoV) analysis across timeframes. The data showed that postprandial movement occurred already at the first imaging point after feeding. The motion of the gastric contents occurred along the central axis of the stomach appearing as a central ‘magenstrasse’ reaching the stomach body/fundus region in 73% of cases. Only in 10% of cases the displacement and smearing of the tag lines was detected close to the stomach walls. Seven % of data sets showed antegrade (towards the antrum) motion whilst a much larger percentage of motion was observed to be only retrograde (43%) or mixed antegrade and retrograde (50%). In conclusion, the MRI tagging method allowed novel insights into the movement of stomach contents using real model porridge meals and confirmed the existence of a central ‘stomach road’ for intragastric flow and mixing of food. |
| first_indexed | 2024-03-11T18:22:41Z |
| format | Article |
| id | doaj.art-f98d9193e65041188205539a1800d1a3 |
| institution | Directory Open Access Journal |
| issn | 2667-2685 |
| language | English |
| last_indexed | 2024-03-11T18:22:41Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Nutrition Open Science |
| spelling | doaj.art-f98d9193e65041188205539a1800d1a32023-10-15T04:38:24ZengElsevierClinical Nutrition Open Science2667-26852023-10-01513543In vivo observation of a stomach road or ‘Magenstrasse’ for gastric emptying using MRI imaging in healthy humansFahad Almutairi0Jaber Alyami1Susan Pritchard2Wala Alsharef3Robin C. Spiller4Penny A. Gowland5Moira A. Taylor6Luca Marciani7Caroline L. Hoad8Department of Diagnostic Radiology, Faculty of Applied Medical Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; Imaging Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 22252, Saudi Arabia; Smart Medical Imaging Research Group, King Abdulaziz University, Jeddah, 22252, Saudi ArabiaDepartment of Diagnostic Radiology, Faculty of Applied Medical Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; Imaging Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 22252, Saudi Arabia; Smart Medical Imaging Research Group, King Abdulaziz University, Jeddah, 22252, Saudi Arabia; NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK; Nottingham Digestive Diseases Centre, Nottingham University Hospitals, NHS Trust and University of Nottingham, Nottingham, UK; Corresponding author.Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, NG7 2RD, UKDepartment of Diagnostic Radiology Technology, Faculty of Applied Medical Sciences, Taibah University, Madinah, 42353, Saudi ArabiaNIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK; Nottingham Digestive Diseases Centre, Nottingham University Hospitals, NHS Trust and University of Nottingham, Nottingham, UKNIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK; Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, NG7 2RD, UKDivision of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Notting-ham, Nottingham NG7 2RD, UKNIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK; Nottingham Digestive Diseases Centre, Nottingham University Hospitals, NHS Trust and University of Nottingham, Nottingham, UKNIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK; Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, NG7 2RD, UKSummary: The presence of a ‘magenstrasse’, a central ‘stomach road’ for flow and mixing of foods and drinks in the stomach had been predicted from hydrodynamic modelling. Here a magnetic resonance imaging (MRI) tagging technique was used to gain novel insights on the intragastric motion of breakfast porridges in 17 healthy humans. They consumed two similar breakfast porridge meals on separate days and tagging images with two different delay times were acquired 15 and 45 minutes postprandially, generating 128 data sets. Motion of the gastric contents was assessed by coefficient of variation (CoV) analysis across timeframes. The data showed that postprandial movement occurred already at the first imaging point after feeding. The motion of the gastric contents occurred along the central axis of the stomach appearing as a central ‘magenstrasse’ reaching the stomach body/fundus region in 73% of cases. Only in 10% of cases the displacement and smearing of the tag lines was detected close to the stomach walls. Seven % of data sets showed antegrade (towards the antrum) motion whilst a much larger percentage of motion was observed to be only retrograde (43%) or mixed antegrade and retrograde (50%). In conclusion, the MRI tagging method allowed novel insights into the movement of stomach contents using real model porridge meals and confirmed the existence of a central ‘stomach road’ for intragastric flow and mixing of food.http://www.sciencedirect.com/science/article/pii/S2667268523000360MRITaggingGastric contentsMotionIntragastric handlingBreakfast |
| spellingShingle | Fahad Almutairi Jaber Alyami Susan Pritchard Wala Alsharef Robin C. Spiller Penny A. Gowland Moira A. Taylor Luca Marciani Caroline L. Hoad In vivo observation of a stomach road or ‘Magenstrasse’ for gastric emptying using MRI imaging in healthy humans Clinical Nutrition Open Science MRI Tagging Gastric contents Motion Intragastric handling Breakfast |
| title | In vivo observation of a stomach road or ‘Magenstrasse’ for gastric emptying using MRI imaging in healthy humans |
| title_full | In vivo observation of a stomach road or ‘Magenstrasse’ for gastric emptying using MRI imaging in healthy humans |
| title_fullStr | In vivo observation of a stomach road or ‘Magenstrasse’ for gastric emptying using MRI imaging in healthy humans |
| title_full_unstemmed | In vivo observation of a stomach road or ‘Magenstrasse’ for gastric emptying using MRI imaging in healthy humans |
| title_short | In vivo observation of a stomach road or ‘Magenstrasse’ for gastric emptying using MRI imaging in healthy humans |
| title_sort | in vivo observation of a stomach road or magenstrasse for gastric emptying using mri imaging in healthy humans |
| topic | MRI Tagging Gastric contents Motion Intragastric handling Breakfast |
| url | http://www.sciencedirect.com/science/article/pii/S2667268523000360 |
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