Transplanted Human Neural Progenitor Cells Attenuate Motor Dysfunction and Lengthen Longevity in a Rat Model of Ataxia

Transplanted Human Neural Progenitor Cells Attenuate Motor Dysfunction and Lengthen Longevity in a Rat Model of Ataxia

The spastic Han Wistar (sHW) rat serves as a model for human ataxia presenting symptoms of motor deterioration, weight loss, shortened lifespan, and Purkinje neuron loss. Past studies revealed that human neural progenitor cells (NPCs) improved ataxic symptoms at 20 d posttransplantation in sHW rats....

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Bibliographic Details
Main Authors: Wesley M. Tierney, Toni L. Uhlendorf, Aaron J.J. Lemus, Bianca A. Ortega, Jesse Magaña, Jessica Ochoa, William Van Trigt, Angelica Cruz, Alex Kopyov, Oleg V. Kopyov, Randy W. Cohen
Format: Article
Language:English
Published: SAGE Publishing 2020-04-01
Series:Cell Transplantation
Online Access:https://doi.org/10.1177/0963689720920275

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