Association between composite scores of domain-specific cognitive functions and regional patterns of atrophy and functional connectivity in the Alzheimer’s disease spectrum

Association between composite scores of domain-specific cognitive functions and regional patterns of atrophy and functional connectivity in the Alzheimer’s disease spectrum

Background: Cognitive decline has been found to be associated with gray matter atrophy and disruption of functional neural networks in Alzheimer’s disease (AD) in structural and functional imaging (fMRI) studies. Most previous studies have used single test scores of cognitive performance among monoc...

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Bibliographic Details
Main Authors: Chimezie O. Amaefule, Martin Dyrba, Steffen Wolfsgruber, Alexandra Polcher, Anja Schneider, Klaus Fliessbach, Annika Spottke, Dix Meiberth, Lukas Preis, Oliver Peters, Enise I. Incesoy, Eike J. Spruth, Josef Priller, Slawek Altenstein, Claudia Bartels, Jens Wiltfang, Daniel Janowitz, Katharina Bürger, Christoph Laske, Matthias Munk, Janna Rudolph, Wenzel Glanz, Laura Dobisch, John D. Haynes, Peter Dechent, Birgit Ertl-Wagner, Klaus Scheffler, Ingo Kilimann, Emrah Düzel, Coraline D. Metzger, Michael Wagner, Frank Jessen, Stefan J. Teipel
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:NeuroImage: Clinical
Subjects:
Visuo-spatial cognitive deficits
Resting-state functional connectivity
Alzheimer’s disease spectrum
Cognitive domain score
Cortical atrophy
Multicenter cohort
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158220303703

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