The nuclear receptor REV-ERBα regulates Fabp7 and modulates adult hippocampal neurogenesis.
The function of the nuclear receptor Rev-erbα (Nr1d1) in the brain is, apart from its role in the circadian clock mechanism, unknown. Therefore, we compared gene expression profiles in the brain between wild-type and Rev-erbα knock-out (KO) animals. We identified fatty acid binding protein 7 (Fabp7,...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4059695?pdf=render |
| _version_ | 1819195629970128896 |
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| author | Anna Schnell Sylvie Chappuis Isabelle Schmutz Emanuele Brai Jürgen A Ripperger Olivier Schaad Hans Welzl Patrick Descombes Lavinia Alberi Urs Albrecht |
| author_facet | Anna Schnell Sylvie Chappuis Isabelle Schmutz Emanuele Brai Jürgen A Ripperger Olivier Schaad Hans Welzl Patrick Descombes Lavinia Alberi Urs Albrecht |
| author_sort | Anna Schnell |
| collection | DOAJ |
| description | The function of the nuclear receptor Rev-erbα (Nr1d1) in the brain is, apart from its role in the circadian clock mechanism, unknown. Therefore, we compared gene expression profiles in the brain between wild-type and Rev-erbα knock-out (KO) animals. We identified fatty acid binding protein 7 (Fabp7, Blbp) as a direct target of repression by REV-ERBα. Loss of Rev-erbα manifested in memory and mood related behavioral phenotypes and led to overexpression of Fabp7 in various brain areas including the subgranular zone (SGZ) of the hippocampus, where neuronal progenitor cells (NPCs) can initiate adult neurogenesis. We found increased proliferation of hippocampal neurons and loss of its diurnal pattern in Rev-erbα KO mice. In vitro, proliferation and migration of glioblastoma cells were affected by manipulating either Fabp7 expression or REV-ERBα activity. These results suggest an important role of Rev-erbα and Fabp7 in adult neurogenesis, which may open new avenues for treatment of gliomas as well as neurological diseases such as depression and Alzheimer. |
| first_indexed | 2024-12-23T02:15:48Z |
| format | Article |
| id | doaj.art-f99128d2de6f49db8e0082437dcb1149 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T02:15:48Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f99128d2de6f49db8e0082437dcb11492022-12-21T18:03:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0196e9988310.1371/journal.pone.0099883The nuclear receptor REV-ERBα regulates Fabp7 and modulates adult hippocampal neurogenesis.Anna SchnellSylvie ChappuisIsabelle SchmutzEmanuele BraiJürgen A RippergerOlivier SchaadHans WelzlPatrick DescombesLavinia AlberiUrs AlbrechtThe function of the nuclear receptor Rev-erbα (Nr1d1) in the brain is, apart from its role in the circadian clock mechanism, unknown. Therefore, we compared gene expression profiles in the brain between wild-type and Rev-erbα knock-out (KO) animals. We identified fatty acid binding protein 7 (Fabp7, Blbp) as a direct target of repression by REV-ERBα. Loss of Rev-erbα manifested in memory and mood related behavioral phenotypes and led to overexpression of Fabp7 in various brain areas including the subgranular zone (SGZ) of the hippocampus, where neuronal progenitor cells (NPCs) can initiate adult neurogenesis. We found increased proliferation of hippocampal neurons and loss of its diurnal pattern in Rev-erbα KO mice. In vitro, proliferation and migration of glioblastoma cells were affected by manipulating either Fabp7 expression or REV-ERBα activity. These results suggest an important role of Rev-erbα and Fabp7 in adult neurogenesis, which may open new avenues for treatment of gliomas as well as neurological diseases such as depression and Alzheimer.http://europepmc.org/articles/PMC4059695?pdf=render |
| spellingShingle | Anna Schnell Sylvie Chappuis Isabelle Schmutz Emanuele Brai Jürgen A Ripperger Olivier Schaad Hans Welzl Patrick Descombes Lavinia Alberi Urs Albrecht The nuclear receptor REV-ERBα regulates Fabp7 and modulates adult hippocampal neurogenesis. PLoS ONE |
| title | The nuclear receptor REV-ERBα regulates Fabp7 and modulates adult hippocampal neurogenesis. |
| title_full | The nuclear receptor REV-ERBα regulates Fabp7 and modulates adult hippocampal neurogenesis. |
| title_fullStr | The nuclear receptor REV-ERBα regulates Fabp7 and modulates adult hippocampal neurogenesis. |
| title_full_unstemmed | The nuclear receptor REV-ERBα regulates Fabp7 and modulates adult hippocampal neurogenesis. |
| title_short | The nuclear receptor REV-ERBα regulates Fabp7 and modulates adult hippocampal neurogenesis. |
| title_sort | nuclear receptor rev erbα regulates fabp7 and modulates adult hippocampal neurogenesis |
| url | http://europepmc.org/articles/PMC4059695?pdf=render |
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