Progenies of NG2 glia: what do we learn from transgenic mouse models ?
In the mammalian central nervous system, nerve-glia antigen 2 (NG2) glia are considered the fourth glial population in addition to astrocytes, oligodendrocytes and microglia. The fate of NG2 glia in vivo has been carefully studied in several transgenic mouse models using the Cre/loxP strategy. There...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=1;spage=43;epage=48;aulast=Guo |
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| author | Qilin Guo Anja Scheller Wenhui Huang |
| author_facet | Qilin Guo Anja Scheller Wenhui Huang |
| author_sort | Qilin Guo |
| collection | DOAJ |
| description | In the mammalian central nervous system, nerve-glia antigen 2 (NG2) glia are considered the fourth glial population in addition to astrocytes, oligodendrocytes and microglia. The fate of NG2 glia in vivo has been carefully studied in several transgenic mouse models using the Cre/loxP strategy. There is a clear agreement that NG2 glia mainly serve as progenitors for oligodendrocytes and a subpopulation of astrocytes mainly in the ventral forebrain, whereas the existence of a neurogenic potential of NG2 glia is lack of adequate evidence. This mini review summarizes the findings from recent studies regarding the fate of NG2 glia during development. We will highlight the age-and-region-dependent heterogeneity of the NG2 glia differentiation potential. We will also discuss putative reasons for inconsistent findings in various transgenic mouse lines of previous studies. |
| first_indexed | 2024-04-13T23:31:11Z |
| format | Article |
| id | doaj.art-f9928ad6a32b4dc7a0cd6ae2a26d727d |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-04-13T23:31:11Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-f9928ad6a32b4dc7a0cd6ae2a26d727d2022-12-22T02:24:54ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742021-01-01161434810.4103/1673-5374.286950Progenies of NG2 glia: what do we learn from transgenic mouse models ?Qilin GuoAnja SchellerWenhui HuangIn the mammalian central nervous system, nerve-glia antigen 2 (NG2) glia are considered the fourth glial population in addition to astrocytes, oligodendrocytes and microglia. The fate of NG2 glia in vivo has been carefully studied in several transgenic mouse models using the Cre/loxP strategy. There is a clear agreement that NG2 glia mainly serve as progenitors for oligodendrocytes and a subpopulation of astrocytes mainly in the ventral forebrain, whereas the existence of a neurogenic potential of NG2 glia is lack of adequate evidence. This mini review summarizes the findings from recent studies regarding the fate of NG2 glia during development. We will highlight the age-and-region-dependent heterogeneity of the NG2 glia differentiation potential. We will also discuss putative reasons for inconsistent findings in various transgenic mouse lines of previous studies.http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=1;spage=43;epage=48;aulast=Guoastrogliogenesis; cell fate; cre/loxp system; development; differentiation; embryonic brain; neurogenesis; ng2 glia; oligodendrocyte lineage; oligodendrocyte precursor cells |
| spellingShingle | Qilin Guo Anja Scheller Wenhui Huang Progenies of NG2 glia: what do we learn from transgenic mouse models ? Neural Regeneration Research astrogliogenesis; cell fate; cre/loxp system; development; differentiation; embryonic brain; neurogenesis; ng2 glia; oligodendrocyte lineage; oligodendrocyte precursor cells |
| title | Progenies of NG2 glia: what do we learn from transgenic mouse models ? |
| title_full | Progenies of NG2 glia: what do we learn from transgenic mouse models ? |
| title_fullStr | Progenies of NG2 glia: what do we learn from transgenic mouse models ? |
| title_full_unstemmed | Progenies of NG2 glia: what do we learn from transgenic mouse models ? |
| title_short | Progenies of NG2 glia: what do we learn from transgenic mouse models ? |
| title_sort | progenies of ng2 glia what do we learn from transgenic mouse models |
| topic | astrogliogenesis; cell fate; cre/loxp system; development; differentiation; embryonic brain; neurogenesis; ng2 glia; oligodendrocyte lineage; oligodendrocyte precursor cells |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=1;spage=43;epage=48;aulast=Guo |
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