First report of Candida auris in Guangdong, China: clinical and microbiological characteristics of 7 episodes of candidemia
ABSTRACTCandida auris is an emerging multidrug-resistant fungal pathogen worldwide. To date, it has not been reported in Guangdong, China. For the first time, we reported 7 cases of C. auris candidemia from two hospitals in Guangdong. The clinical and microbiological characteristics of these cases w...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2023.2300525 |
| _version_ | 1797362679641276416 |
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| author | Yaqin Peng Yue Liu Xuegao Yu Jingchun Fang Zhaowang Guo Kang Liao Peisong Chen Penghao Guo |
| author_facet | Yaqin Peng Yue Liu Xuegao Yu Jingchun Fang Zhaowang Guo Kang Liao Peisong Chen Penghao Guo |
| author_sort | Yaqin Peng |
| collection | DOAJ |
| description | ABSTRACTCandida auris is an emerging multidrug-resistant fungal pathogen worldwide. To date, it has not been reported in Guangdong, China. For the first time, we reported 7 cases of C. auris candidemia from two hospitals in Guangdong. The clinical and microbiological characteristics of these cases were investigated carefully. Two geographic clades, i.e. III and I, were found popular in different hospitals by whole genome sequencing analyses. All C. auris isolates from bloodstream were resistant to fluconazole, 5 of which belonged to Clade III harbouring VF125AL mutation in the ERG11 gene. The isolates with Clade I presented Y132F mutation in the ERG11 gene as well as resistance to amphotericin B. All isolates exhibited strong biofilm-forming capacity and non-aggregative phenotype. The mean time from admission to onset of C. auris candidemia was 39.4 days (range: 12 - 80 days). Despite performing appropriate therapeutic regimen, 42.9% (3/7) of patients experienced occurrences of C. auris candidemia and colonization after the first positive bloodstream. C. auris colonization was still observed after the first C. auris candidemia for 81 days in some patient. Microbiologic eradication from bloodstream was achieved in 85.7% (6/7) of patients at discharge. In conclusion, this study offers a crucial insight into unravelling the multiple origins of C. auris in Guangdong, highlighting great challenges in clinical prevention and control. |
| first_indexed | 2024-03-08T16:10:58Z |
| format | Article |
| id | doaj.art-f9947f5851894873a4030e19d80cfd65 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-03-08T16:10:58Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-f9947f5851894873a4030e19d80cfd652024-01-07T23:13:02ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512024-12-0113110.1080/22221751.2023.2300525First report of Candida auris in Guangdong, China: clinical and microbiological characteristics of 7 episodes of candidemiaYaqin Peng0Yue Liu1Xuegao Yu2Jingchun Fang3Zhaowang Guo4Kang Liao5Peisong Chen6Penghao Guo7Department of Clinical Laboratory, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of ChinaDepartment of Clinical Laboratory, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of ChinaDepartment of Clinical Laboratory, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of ChinaDepartment of Clinical Microbiology Laboratory, Nansha Division of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of ChinaDepartment of Clinical Laboratory, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, People’s Republic of ChinaDepartment of Clinical Laboratory, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of ChinaDepartment of Clinical Laboratory, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of ChinaDepartment of Clinical Laboratory, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of ChinaABSTRACTCandida auris is an emerging multidrug-resistant fungal pathogen worldwide. To date, it has not been reported in Guangdong, China. For the first time, we reported 7 cases of C. auris candidemia from two hospitals in Guangdong. The clinical and microbiological characteristics of these cases were investigated carefully. Two geographic clades, i.e. III and I, were found popular in different hospitals by whole genome sequencing analyses. All C. auris isolates from bloodstream were resistant to fluconazole, 5 of which belonged to Clade III harbouring VF125AL mutation in the ERG11 gene. The isolates with Clade I presented Y132F mutation in the ERG11 gene as well as resistance to amphotericin B. All isolates exhibited strong biofilm-forming capacity and non-aggregative phenotype. The mean time from admission to onset of C. auris candidemia was 39.4 days (range: 12 - 80 days). Despite performing appropriate therapeutic regimen, 42.9% (3/7) of patients experienced occurrences of C. auris candidemia and colonization after the first positive bloodstream. C. auris colonization was still observed after the first C. auris candidemia for 81 days in some patient. Microbiologic eradication from bloodstream was achieved in 85.7% (6/7) of patients at discharge. In conclusion, this study offers a crucial insight into unravelling the multiple origins of C. auris in Guangdong, highlighting great challenges in clinical prevention and control.https://www.tandfonline.com/doi/10.1080/22221751.2023.2300525Candida auriscandidemiawhole-genome sequencingresistanceoutcome |
| spellingShingle | Yaqin Peng Yue Liu Xuegao Yu Jingchun Fang Zhaowang Guo Kang Liao Peisong Chen Penghao Guo First report of Candida auris in Guangdong, China: clinical and microbiological characteristics of 7 episodes of candidemia Emerging Microbes and Infections Candida auris candidemia whole-genome sequencing resistance outcome |
| title | First report of Candida auris in Guangdong, China: clinical and microbiological characteristics of 7 episodes of candidemia |
| title_full | First report of Candida auris in Guangdong, China: clinical and microbiological characteristics of 7 episodes of candidemia |
| title_fullStr | First report of Candida auris in Guangdong, China: clinical and microbiological characteristics of 7 episodes of candidemia |
| title_full_unstemmed | First report of Candida auris in Guangdong, China: clinical and microbiological characteristics of 7 episodes of candidemia |
| title_short | First report of Candida auris in Guangdong, China: clinical and microbiological characteristics of 7 episodes of candidemia |
| title_sort | first report of candida auris in guangdong china clinical and microbiological characteristics of 7 episodes of candidemia |
| topic | Candida auris candidemia whole-genome sequencing resistance outcome |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2023.2300525 |
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