First report of treatment failure in a patient with cutaneous leishmaniasis infected by Leishmania (Viannia) naiffi carrying Leishmania RNA virus: a fortuitous combination?
Abstract We report the case of a 32-year-old man from Rio de Janeiro, who was infected in the Amazon region of Brazil by Leishmania (Viannia) naiffi. Generally, patients with L. naiffi cutaneous leishmaniasis exhibit a good therapeutic response to either pentavalent antimonials or pentamidine. Howev...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2019-04-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100709&lng=en&tlng=en |
| _version_ | 1818263659224236032 |
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| author | Ricardo Vieira-Gonçalves Giselle Aparecida Fagundes-Silva Júlia Furtado Heringer Maria Fantinatti Alda Maria Da-Cruz Manoel Paes Oliveira-Neto Jorge Augusto Oliveira Guerra Adriano Gomes-Silva |
| author_facet | Ricardo Vieira-Gonçalves Giselle Aparecida Fagundes-Silva Júlia Furtado Heringer Maria Fantinatti Alda Maria Da-Cruz Manoel Paes Oliveira-Neto Jorge Augusto Oliveira Guerra Adriano Gomes-Silva |
| author_sort | Ricardo Vieira-Gonçalves |
| collection | DOAJ |
| description | Abstract We report the case of a 32-year-old man from Rio de Janeiro, who was infected in the Amazon region of Brazil by Leishmania (Viannia) naiffi. Generally, patients with L. naiffi cutaneous leishmaniasis exhibit a good therapeutic response to either pentavalent antimonials or pentamidine. However, after pentamidine treatment, this patient’s infection evolved to therapeutic failure. To understand this clinical outcome, we investigated the presence of the Leishmania RNA virus (LRV) in parasites isolated from the cutaneous lesion; herein, we discuss the possible association between a poor response to pentamidine therapy and the presence of the LRV. |
| first_indexed | 2024-12-12T19:22:32Z |
| format | Article |
| id | doaj.art-f9957c141a074a4eb23aea3290720200 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-12-12T19:22:32Z |
| publishDate | 2019-04-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-f9957c141a074a4eb23aea32907202002022-12-22T00:14:35ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492019-04-0152010.1590/0037-8682-0323-2018S0037-86822019000100709First report of treatment failure in a patient with cutaneous leishmaniasis infected by Leishmania (Viannia) naiffi carrying Leishmania RNA virus: a fortuitous combination?Ricardo Vieira-GonçalvesGiselle Aparecida Fagundes-SilvaJúlia Furtado HeringerMaria FantinattiAlda Maria Da-CruzManoel Paes Oliveira-NetoJorge Augusto Oliveira GuerraAdriano Gomes-SilvaAbstract We report the case of a 32-year-old man from Rio de Janeiro, who was infected in the Amazon region of Brazil by Leishmania (Viannia) naiffi. Generally, patients with L. naiffi cutaneous leishmaniasis exhibit a good therapeutic response to either pentavalent antimonials or pentamidine. However, after pentamidine treatment, this patient’s infection evolved to therapeutic failure. To understand this clinical outcome, we investigated the presence of the Leishmania RNA virus (LRV) in parasites isolated from the cutaneous lesion; herein, we discuss the possible association between a poor response to pentamidine therapy and the presence of the LRV.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100709&lng=en&tlng=enLeishmania (Viannia) naiffiTherapeutic failureLeishmania RNA virus |
| spellingShingle | Ricardo Vieira-Gonçalves Giselle Aparecida Fagundes-Silva Júlia Furtado Heringer Maria Fantinatti Alda Maria Da-Cruz Manoel Paes Oliveira-Neto Jorge Augusto Oliveira Guerra Adriano Gomes-Silva First report of treatment failure in a patient with cutaneous leishmaniasis infected by Leishmania (Viannia) naiffi carrying Leishmania RNA virus: a fortuitous combination? Revista da Sociedade Brasileira de Medicina Tropical Leishmania (Viannia) naiffi Therapeutic failure Leishmania RNA virus |
| title | First report of treatment failure in a patient with cutaneous leishmaniasis infected by Leishmania (Viannia) naiffi carrying Leishmania RNA virus: a fortuitous combination? |
| title_full | First report of treatment failure in a patient with cutaneous leishmaniasis infected by Leishmania (Viannia) naiffi carrying Leishmania RNA virus: a fortuitous combination? |
| title_fullStr | First report of treatment failure in a patient with cutaneous leishmaniasis infected by Leishmania (Viannia) naiffi carrying Leishmania RNA virus: a fortuitous combination? |
| title_full_unstemmed | First report of treatment failure in a patient with cutaneous leishmaniasis infected by Leishmania (Viannia) naiffi carrying Leishmania RNA virus: a fortuitous combination? |
| title_short | First report of treatment failure in a patient with cutaneous leishmaniasis infected by Leishmania (Viannia) naiffi carrying Leishmania RNA virus: a fortuitous combination? |
| title_sort | first report of treatment failure in a patient with cutaneous leishmaniasis infected by leishmania viannia naiffi carrying leishmania rna virus a fortuitous combination |
| topic | Leishmania (Viannia) naiffi Therapeutic failure Leishmania RNA virus |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100709&lng=en&tlng=en |
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