Self-Replication of Prion Protein Fragment 89-230 Amyloid Fibrils Accelerated by Prion Protein Fragment 107-143 Aggregates

Self-Replication of Prion Protein Fragment 89-230 Amyloid Fibrils Accelerated by Prion Protein Fragment 107-143 Aggregates

Prion protein amyloid aggregates are associated with infectious neurodegenerative diseases, known as transmissible spongiform encephalopathies. Self-replication of amyloid structures by refolding of native protein molecules is the probable mechanism of disease transmission. Amyloid fibril formation...

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Bibliographic Details
Main Authors: Tomas Sneideris, Mantas Ziaunys, Brett K.-Y. Chu, Rita P.-Y. Chen, Vytautas Smirnovas
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
amyloid
prion
aggregation
self-replication
Online Access:https://www.mdpi.com/1422-0067/21/19/7410

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