Endurance exercise preconditioning alleviates ferroptosis induced by doxorubicin-induced cardiotoxicity through mitochondrial superoxide-dependent AMPKα2 activation

Endurance exercise preconditioning alleviates ferroptosis induced by doxorubicin-induced cardiotoxicity through mitochondrial superoxide-dependent AMPKα2 activation

Doxorubicin-induced cardiotoxicity (DIC) adversely impacts patients' long-term health and quality of life. Its underlying mechanism is complex, involving regulatory cell death mechanisms, such as ferroptosis and autophagy. Moreover, it is a challenge faced by patients undergoing cardiac rehabil...

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Bibliographic Details
Main Authors: Liang Wang, Yang Qiao, Jingzhi Yu, Qihao Wang, Xinyu Wu, Qiqi Cao, Zeyu Zhang, Zhen Feng, Huan He
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Redox Biology
Subjects:
Endurance exercise
AMP-Activated protein kinaseα2
Doxorubicin-induced cardiotoxicity
Ferroptosis
Mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724000557

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