Brazilian multicentre study on preterm birth (EMIP): prevalence and factors associated with spontaneous preterm birth.
Preterm birth rate is increasing and is currently a worldwide concern. The purpose of this study was to estimate the prevalence of preterm birth in a sample of health facilities in Brazil and to identify the main risk factors associated with spontaneous preterm births.This was a multicentre cross se...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4192080?pdf=render |
| _version_ | 1818953005220757504 |
|---|---|
| author | Renato Passini Jose G Cecatti Giuliane J Lajos Ricardo P Tedesco Marcelo L Nomura Tabata Z Dias Samira M Haddad Patricia M Rehder Rodolfo C Pacagnella Maria L Costa Maria H Sousa Brazilian Multicentre Study on Preterm Birth study group |
| author_facet | Renato Passini Jose G Cecatti Giuliane J Lajos Ricardo P Tedesco Marcelo L Nomura Tabata Z Dias Samira M Haddad Patricia M Rehder Rodolfo C Pacagnella Maria L Costa Maria H Sousa Brazilian Multicentre Study on Preterm Birth study group |
| author_sort | Renato Passini |
| collection | DOAJ |
| description | Preterm birth rate is increasing and is currently a worldwide concern. The purpose of this study was to estimate the prevalence of preterm birth in a sample of health facilities in Brazil and to identify the main risk factors associated with spontaneous preterm births.This was a multicentre cross sectional study on preterm births in 20 referral obstetric hospitals with a case-control component to identify factors associated with spontaneous preterm birth. Surveillance was implemented at all centres to identify preterm births. For eligible consenting women, data were collected through a post-delivery questionnaire completed with information from all mother-newborn medical records until death or discharge or at a maximum of 60 days post-delivery, whichever came first. The risk of spontaneous preterm birth was estimated with OR and 95%CI for several predictors. A non-conditional logistic regression analysis was then performed to identify independently associated factors. The overall prevalence of preterm birth was 12.3%. Among them, 64.6% were spontaneous and 35.4% therapeutic. In the case-control component, 2,682 spontaneous preterm births were compared to a sample of 1,146 term births. Multivariate analyses identified the following as risk factors for spontaneous preterm birth among women with at least one previous birth: a previous preterm birth (ORadj = 3.19, 2.30-4.43), multiple pregnancy (ORadj = 29.06, 8.43-100.2), cervical insufficiency (ORadj = 2.93, 1.07-8.05), foetal malformation (ORadj = 2.63, 1.43-4.85), polyhydramnios (ORadj = 2.30, 1.17-4.54), vaginal bleeding (ORadj = 2.16, 1.50-3.11), and previous abortion (ORadj = 1.39, 1.08-1.78). High BMI (ORadj = 0.94, 0.91-0.97) and weight gain during gestation (ORadj = 0.92, 0.89-0.95) were found to be protective factors.The preterm birth rate in these health facilities in Brazil is high and spontaneous preterm births account for two thirds of them. A better understanding of the factors associated with spontaneous preterm birth is of utmost importance for planning effective measures to reduce the burden of its increasing rates. |
| first_indexed | 2024-12-20T09:59:23Z |
| format | Article |
| id | doaj.art-f998a1c70bb246c0a1b40d44b86304c5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T09:59:23Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f998a1c70bb246c0a1b40d44b86304c52022-12-21T19:44:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01910e10906910.1371/journal.pone.0109069Brazilian multicentre study on preterm birth (EMIP): prevalence and factors associated with spontaneous preterm birth.Renato PassiniJose G CecattiGiuliane J LajosRicardo P TedescoMarcelo L NomuraTabata Z DiasSamira M HaddadPatricia M RehderRodolfo C PacagnellaMaria L CostaMaria H SousaBrazilian Multicentre Study on Preterm Birth study groupPreterm birth rate is increasing and is currently a worldwide concern. The purpose of this study was to estimate the prevalence of preterm birth in a sample of health facilities in Brazil and to identify the main risk factors associated with spontaneous preterm births.This was a multicentre cross sectional study on preterm births in 20 referral obstetric hospitals with a case-control component to identify factors associated with spontaneous preterm birth. Surveillance was implemented at all centres to identify preterm births. For eligible consenting women, data were collected through a post-delivery questionnaire completed with information from all mother-newborn medical records until death or discharge or at a maximum of 60 days post-delivery, whichever came first. The risk of spontaneous preterm birth was estimated with OR and 95%CI for several predictors. A non-conditional logistic regression analysis was then performed to identify independently associated factors. The overall prevalence of preterm birth was 12.3%. Among them, 64.6% were spontaneous and 35.4% therapeutic. In the case-control component, 2,682 spontaneous preterm births were compared to a sample of 1,146 term births. Multivariate analyses identified the following as risk factors for spontaneous preterm birth among women with at least one previous birth: a previous preterm birth (ORadj = 3.19, 2.30-4.43), multiple pregnancy (ORadj = 29.06, 8.43-100.2), cervical insufficiency (ORadj = 2.93, 1.07-8.05), foetal malformation (ORadj = 2.63, 1.43-4.85), polyhydramnios (ORadj = 2.30, 1.17-4.54), vaginal bleeding (ORadj = 2.16, 1.50-3.11), and previous abortion (ORadj = 1.39, 1.08-1.78). High BMI (ORadj = 0.94, 0.91-0.97) and weight gain during gestation (ORadj = 0.92, 0.89-0.95) were found to be protective factors.The preterm birth rate in these health facilities in Brazil is high and spontaneous preterm births account for two thirds of them. A better understanding of the factors associated with spontaneous preterm birth is of utmost importance for planning effective measures to reduce the burden of its increasing rates.http://europepmc.org/articles/PMC4192080?pdf=render |
| spellingShingle | Renato Passini Jose G Cecatti Giuliane J Lajos Ricardo P Tedesco Marcelo L Nomura Tabata Z Dias Samira M Haddad Patricia M Rehder Rodolfo C Pacagnella Maria L Costa Maria H Sousa Brazilian Multicentre Study on Preterm Birth study group Brazilian multicentre study on preterm birth (EMIP): prevalence and factors associated with spontaneous preterm birth. PLoS ONE |
| title | Brazilian multicentre study on preterm birth (EMIP): prevalence and factors associated with spontaneous preterm birth. |
| title_full | Brazilian multicentre study on preterm birth (EMIP): prevalence and factors associated with spontaneous preterm birth. |
| title_fullStr | Brazilian multicentre study on preterm birth (EMIP): prevalence and factors associated with spontaneous preterm birth. |
| title_full_unstemmed | Brazilian multicentre study on preterm birth (EMIP): prevalence and factors associated with spontaneous preterm birth. |
| title_short | Brazilian multicentre study on preterm birth (EMIP): prevalence and factors associated with spontaneous preterm birth. |
| title_sort | brazilian multicentre study on preterm birth emip prevalence and factors associated with spontaneous preterm birth |
| url | http://europepmc.org/articles/PMC4192080?pdf=render |
| work_keys_str_mv | AT renatopassini brazilianmulticentrestudyonpretermbirthemipprevalenceandfactorsassociatedwithspontaneouspretermbirth AT josegcecatti brazilianmulticentrestudyonpretermbirthemipprevalenceandfactorsassociatedwithspontaneouspretermbirth AT giulianejlajos brazilianmulticentrestudyonpretermbirthemipprevalenceandfactorsassociatedwithspontaneouspretermbirth AT ricardoptedesco brazilianmulticentrestudyonpretermbirthemipprevalenceandfactorsassociatedwithspontaneouspretermbirth AT marcelolnomura brazilianmulticentrestudyonpretermbirthemipprevalenceandfactorsassociatedwithspontaneouspretermbirth AT tabatazdias brazilianmulticentrestudyonpretermbirthemipprevalenceandfactorsassociatedwithspontaneouspretermbirth AT samiramhaddad brazilianmulticentrestudyonpretermbirthemipprevalenceandfactorsassociatedwithspontaneouspretermbirth AT patriciamrehder brazilianmulticentrestudyonpretermbirthemipprevalenceandfactorsassociatedwithspontaneouspretermbirth AT rodolfocpacagnella brazilianmulticentrestudyonpretermbirthemipprevalenceandfactorsassociatedwithspontaneouspretermbirth AT marialcosta brazilianmulticentrestudyonpretermbirthemipprevalenceandfactorsassociatedwithspontaneouspretermbirth AT mariahsousa brazilianmulticentrestudyonpretermbirthemipprevalenceandfactorsassociatedwithspontaneouspretermbirth AT brazilianmulticentrestudyonpretermbirthstudygroup brazilianmulticentrestudyonpretermbirthemipprevalenceandfactorsassociatedwithspontaneouspretermbirth |