Exploring the mechanism of Artemisia argyi chemical composition for ulcerative colitis based on network pharmacology
A persistent digestive disorder known as ulcerative colitis (UC) is characterized by a high rate of recurrence and a difficult road to full recovery. An herbal treatment with a long history of use in conventional Chinese medicine, Artemisia argyi, has shown encouraging results in preventing the retu...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535223005129 |
| _version_ | 1797776694588735488 |
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| author | Menghe Li Jianghao Liu Caiwenjie La Tao Liu Zibo Zhao Zui Wang Minghui Dai Jiming Chen Zhe Ren Cuifang Ye Yifei Wang |
| author_facet | Menghe Li Jianghao Liu Caiwenjie La Tao Liu Zibo Zhao Zui Wang Minghui Dai Jiming Chen Zhe Ren Cuifang Ye Yifei Wang |
| author_sort | Menghe Li |
| collection | DOAJ |
| description | A persistent digestive disorder known as ulcerative colitis (UC) is characterized by a high rate of recurrence and a difficult road to full recovery. An herbal treatment with a long history of use in conventional Chinese medicine, Artemisia argyi, has shown encouraging results in preventing the return of clinical UC. We carried out an experiment to isolate and identify the small molecules in Artemisia argyi to investigate the chemical makeup of the therapeutic UC in this plant. Following an activity screen, we discovered that 3β-ethoxytanapartholide (ETP) had significantly greater anti-inflammatory action than the medicine we had chosen as a positive control, dexamethasone, and this is the first report of ETP in terms of biological activity. Systematic network pharmacological analysis confirmed that ETP acted on multiple targets during the pathogenesis of UC. These targets regulate a variety of UC-related signaling pathways, including but not limited to TNF, IL-17, and Ca2+ signaling. Molecular dynamics simulations and MM-PBSA results showed that ETP was able to form stable complexes with five targets, MMP1, MMP9, MUC1, S1PR1 and MMP12. The current work has previously shown the unknown anti-inflammatory ability of ETP and discovered that ETP can modulate various pathways throughout the development of UC to produce therapeutic advantages. These ground-breaking results highlight the urgent need for more analysis and development of ETP as a potential treatment plan for UC. |
| first_indexed | 2024-03-12T22:53:33Z |
| format | Article |
| id | doaj.art-f999184de24c4e80b6954e8c2f888319 |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-03-12T22:53:33Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-f999184de24c4e80b6954e8c2f8883192023-07-20T04:38:00ZengElsevierArabian Journal of Chemistry1878-53522023-09-01169105050Exploring the mechanism of Artemisia argyi chemical composition for ulcerative colitis based on network pharmacologyMenghe Li0Jianghao Liu1Caiwenjie La2Tao Liu3Zibo Zhao4Zui Wang5Minghui Dai6Jiming Chen7Zhe Ren8Cuifang Ye9Yifei Wang10Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China; Guangdong Provincial Biotechnology Drug & Engineering Technology Research Center, Guangzhou, ChinaDepartment of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China; Guangdong Provincial Biotechnology Drug & Engineering Technology Research Center, Guangzhou, ChinaDepartment of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China; Guangdong Provincial Biotechnology Drug & Engineering Technology Research Center, Guangzhou, ChinaDepartment of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China; Guangdong Provincial Biotechnology Drug & Engineering Technology Research Center, Guangzhou, ChinaDepartment of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China; Guangdong Provincial Biotechnology Drug & Engineering Technology Research Center, Guangzhou, ChinaGuangdong Provincial Engineering Center of Topical Precise Drug Delivery System, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, ChinaDepartment of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China; Guangdong Provincial Biotechnology Drug & Engineering Technology Research Center, Guangzhou, ChinaGuangdong Provincial Engineering Center of Topical Precise Drug Delivery System, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, ChinaDepartment of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China; Guangdong Provincial Biotechnology Drug & Engineering Technology Research Center, Guangzhou, ChinaDepartment of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China; Guangdong Provincial Biotechnology Drug & Engineering Technology Research Center, Guangzhou, China; Corresponding authors at: Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China.Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China; Guangdong Provincial Biotechnology Drug & Engineering Technology Research Center, Guangzhou, China; GuangZhou (Jinan) Biomedical Research and Development Center Co. Ltd, Guangzhou, China; Key Laboratory of Innovative Technology Research on Natural Products and Cosmetics Raw Materials, Guangzhou, China; National Engineering Research Center for Modernization of Traditional Chinese Medicine- Artemisia Argyi Branch Center, Guangzhou, China; Corresponding authors at: Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China.A persistent digestive disorder known as ulcerative colitis (UC) is characterized by a high rate of recurrence and a difficult road to full recovery. An herbal treatment with a long history of use in conventional Chinese medicine, Artemisia argyi, has shown encouraging results in preventing the return of clinical UC. We carried out an experiment to isolate and identify the small molecules in Artemisia argyi to investigate the chemical makeup of the therapeutic UC in this plant. Following an activity screen, we discovered that 3β-ethoxytanapartholide (ETP) had significantly greater anti-inflammatory action than the medicine we had chosen as a positive control, dexamethasone, and this is the first report of ETP in terms of biological activity. Systematic network pharmacological analysis confirmed that ETP acted on multiple targets during the pathogenesis of UC. These targets regulate a variety of UC-related signaling pathways, including but not limited to TNF, IL-17, and Ca2+ signaling. Molecular dynamics simulations and MM-PBSA results showed that ETP was able to form stable complexes with five targets, MMP1, MMP9, MUC1, S1PR1 and MMP12. The current work has previously shown the unknown anti-inflammatory ability of ETP and discovered that ETP can modulate various pathways throughout the development of UC to produce therapeutic advantages. These ground-breaking results highlight the urgent need for more analysis and development of ETP as a potential treatment plan for UC.http://www.sciencedirect.com/science/article/pii/S1878535223005129Artemisia argyiNatural products3β-ethoxytanapartholideNetwork pharmacology |
| spellingShingle | Menghe Li Jianghao Liu Caiwenjie La Tao Liu Zibo Zhao Zui Wang Minghui Dai Jiming Chen Zhe Ren Cuifang Ye Yifei Wang Exploring the mechanism of Artemisia argyi chemical composition for ulcerative colitis based on network pharmacology Arabian Journal of Chemistry Artemisia argyi Natural products 3β-ethoxytanapartholide Network pharmacology |
| title | Exploring the mechanism of Artemisia argyi chemical composition for ulcerative colitis based on network pharmacology |
| title_full | Exploring the mechanism of Artemisia argyi chemical composition for ulcerative colitis based on network pharmacology |
| title_fullStr | Exploring the mechanism of Artemisia argyi chemical composition for ulcerative colitis based on network pharmacology |
| title_full_unstemmed | Exploring the mechanism of Artemisia argyi chemical composition for ulcerative colitis based on network pharmacology |
| title_short | Exploring the mechanism of Artemisia argyi chemical composition for ulcerative colitis based on network pharmacology |
| title_sort | exploring the mechanism of artemisia argyi chemical composition for ulcerative colitis based on network pharmacology |
| topic | Artemisia argyi Natural products 3β-ethoxytanapartholide Network pharmacology |
| url | http://www.sciencedirect.com/science/article/pii/S1878535223005129 |
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