Ethnicity, Progressive Keratoconus, and Outcomes after Corneal Cross-Linking in Southern Israel
Purpose: To assess clinical outcomes of corneal cross-linking (CXL) intervention in a population diagnosed with progressive keratoconus. Methods: This single-center retrospective cohort study included consecutive patients who underwent standard CXL or accelerated CXL for progressive keratoconus at a...
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MDPI AG
2023-12-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/12/2294 |
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| author | Jacob A. Yaffe Ran Matlov Kormas Boris E. Malyugin Matthew Boyko Raimo Tuuminen Boris Knyazer |
| author_facet | Jacob A. Yaffe Ran Matlov Kormas Boris E. Malyugin Matthew Boyko Raimo Tuuminen Boris Knyazer |
| author_sort | Jacob A. Yaffe |
| collection | DOAJ |
| description | Purpose: To assess clinical outcomes of corneal cross-linking (CXL) intervention in a population diagnosed with progressive keratoconus. Methods: This single-center retrospective cohort study included consecutive patients who underwent standard CXL or accelerated CXL for progressive keratoconus at a major teaching hospital in southern Israel between January 2015 and December 2019. Patients’ medical files were reviewed, and pre-operative and post-operative data regarding demographics and clinical and tomographic characteristics were extracted and analyzed. Results: This study included 166 patients (representing 198 eyes), out of which 98 patients (123 eyes) were ethnically Bedouin, and 68 patients (75 eyes) were ethnically Jewish. Overall, 126 patients (144 eyes) had a follow-up of at least 12 months (16.84 ± 5.76). The mean patient age was 20.62 ± 7.1 years old. There were significant baseline differences between the two ethnic groups in best-corrected visual acuity (BCVA; <i>p</i> < 0.001), uncorrected visual acuity (UCVA; <i>p</i> < 0.001), mean keratometry (<i>p</i> = 0.028), and corneal thickness (<i>p</i> < 0.001). Significant changes in BCVA, UCVA, and pachymetry parameters within each group were found after 12 months. Negative binomial regression analysis showed a maximal keratometry below 55D (RR = 1.247, <i>p <</i> 0.001), and a standard CXL procedure (RR = 1.147, <i>p</i> = 0.041) are significantly related to the stability of KC after 12 months. However, the effect size of the origin of patients is negligible (RR = 1.047, <i>p</i> = 0.47). Conclusions: In this study, the Bedouin population suffered from more progressive keratoconus when compared to the Jewish population. CXL was significantly effective in improving BCVA and UCVA in both groups after 12 months of follow-up. The effect size of the origin of patients on the stability of KC was found to be negligible. |
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| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-08T20:36:23Z |
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| spelling | doaj.art-f999d470c2ce4013b07ce3b7790b55aa2023-12-22T14:21:13ZengMDPI AGLife2075-17292023-12-011312229410.3390/life13122294Ethnicity, Progressive Keratoconus, and Outcomes after Corneal Cross-Linking in Southern IsraelJacob A. Yaffe0Ran Matlov Kormas1Boris E. Malyugin2Matthew Boyko3Raimo Tuuminen4Boris Knyazer5Department of Ophthalmology, Soroka University Medical Center, Beer Sheva 8457108, IsraelDepartment of Ophthalmology, Soroka University Medical Center, Beer Sheva 8457108, IsraelS. Fyodorov Eye Microsurgery Federal Institution, Moscow 127486, RussiaDepartment of Anesthesiology and Critical Care, Soroka University Medical Center, Ben Gurion University of the Negev, Beer Sheva 8457108, IsraelHelsinki Retina Research Group, Faculty of Medicine, University of Helsinki, 00014 Helsinki, FinlandDepartment of Ophthalmology, Soroka University Medical Center, Beer Sheva 8457108, IsraelPurpose: To assess clinical outcomes of corneal cross-linking (CXL) intervention in a population diagnosed with progressive keratoconus. Methods: This single-center retrospective cohort study included consecutive patients who underwent standard CXL or accelerated CXL for progressive keratoconus at a major teaching hospital in southern Israel between January 2015 and December 2019. Patients’ medical files were reviewed, and pre-operative and post-operative data regarding demographics and clinical and tomographic characteristics were extracted and analyzed. Results: This study included 166 patients (representing 198 eyes), out of which 98 patients (123 eyes) were ethnically Bedouin, and 68 patients (75 eyes) were ethnically Jewish. Overall, 126 patients (144 eyes) had a follow-up of at least 12 months (16.84 ± 5.76). The mean patient age was 20.62 ± 7.1 years old. There were significant baseline differences between the two ethnic groups in best-corrected visual acuity (BCVA; <i>p</i> < 0.001), uncorrected visual acuity (UCVA; <i>p</i> < 0.001), mean keratometry (<i>p</i> = 0.028), and corneal thickness (<i>p</i> < 0.001). Significant changes in BCVA, UCVA, and pachymetry parameters within each group were found after 12 months. Negative binomial regression analysis showed a maximal keratometry below 55D (RR = 1.247, <i>p <</i> 0.001), and a standard CXL procedure (RR = 1.147, <i>p</i> = 0.041) are significantly related to the stability of KC after 12 months. However, the effect size of the origin of patients is negligible (RR = 1.047, <i>p</i> = 0.47). Conclusions: In this study, the Bedouin population suffered from more progressive keratoconus when compared to the Jewish population. CXL was significantly effective in improving BCVA and UCVA in both groups after 12 months of follow-up. The effect size of the origin of patients on the stability of KC was found to be negligible.https://www.mdpi.com/2075-1729/13/12/2294epidemiologyectasiaBedouinJewishK<sub>max</sub> |
| spellingShingle | Jacob A. Yaffe Ran Matlov Kormas Boris E. Malyugin Matthew Boyko Raimo Tuuminen Boris Knyazer Ethnicity, Progressive Keratoconus, and Outcomes after Corneal Cross-Linking in Southern Israel Life epidemiology ectasia Bedouin Jewish K<sub>max</sub> |
| title | Ethnicity, Progressive Keratoconus, and Outcomes after Corneal Cross-Linking in Southern Israel |
| title_full | Ethnicity, Progressive Keratoconus, and Outcomes after Corneal Cross-Linking in Southern Israel |
| title_fullStr | Ethnicity, Progressive Keratoconus, and Outcomes after Corneal Cross-Linking in Southern Israel |
| title_full_unstemmed | Ethnicity, Progressive Keratoconus, and Outcomes after Corneal Cross-Linking in Southern Israel |
| title_short | Ethnicity, Progressive Keratoconus, and Outcomes after Corneal Cross-Linking in Southern Israel |
| title_sort | ethnicity progressive keratoconus and outcomes after corneal cross linking in southern israel |
| topic | epidemiology ectasia Bedouin Jewish K<sub>max</sub> |
| url | https://www.mdpi.com/2075-1729/13/12/2294 |
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