Maternal incompatibilities with fetal human platelet alloantigens -1a, -1b and -15 are the main causes of neonatal alloimmune thrombocytopenia in Russia
The aim. Mechanisms underlying the development of neonatal alloimmune thrombocytopenia (NAIT) in in Russia have been studied. Materials and methods. Genetic polymorphisms of human platelet alloantigens (HPA) -1, -2, -3, -4, -5, and -15 were evaluated in 27 families having the newborns with NAIT. NAI...
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2018-07-01
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| Series: | Терапевтический архив |
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| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/32783/pdf |
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| author | S G KHASPEKOVA L L GOLOVKINA E K DONUSH N V GOLUBEVA O N SHUSTOVA A V MAZUROV |
| author_facet | S G KHASPEKOVA L L GOLOVKINA E K DONUSH N V GOLUBEVA O N SHUSTOVA A V MAZUROV |
| author_sort | S G KHASPEKOVA |
| collection | DOAJ |
| description | The aim. Mechanisms underlying the development of neonatal alloimmune thrombocytopenia (NAIT) in in Russia have been studied. Materials and methods. Genetic polymorphisms of human platelet alloantigens (HPA) -1, -2, -3, -4, -5, and -15 were evaluated in 27 families having the newborns with NAIT. NAIT was diagnosed according to the following criteria: (1) newborn with thrombocytopenia; (2) mother with no thrombocytopenia and no increase of platelet associated IgG, (3) presence of antibodies reacting with paternal platelets in maternal plasma / serum. HPA genotyping revealed incompatibilities in 23 out of 27 tested families. In these 23 families HPA-1 conflicts were detected in 16 ones (70%). In 8 cases mothers were homozygous carriers of rare HPA-1b allele and in another 8 cases - of HPA-1a allele which cased incompatibilities with fetal HPA-1a and HPA-1b respectively. In 5 out of 23 families (22%) there were incompatibilities with fetal HPA-15 (HPA-15a, n=2 and HPA-15b, n=3), in 1 family - with HPA-5b (4%), and in 1 family - with HPA-3b (4%) alloantigens. In conclusion the main causes of NAIT in Russia were HPA-1a and -1b conflicts and HPA-15 conflicts were the second frequent ones. |
| first_indexed | 2024-12-19T05:23:45Z |
| format | Article |
| id | doaj.art-f99c07067f014812a13fbb08f8bd7eb5 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-19T05:23:45Z |
| publishDate | 2018-07-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-f99c07067f014812a13fbb08f8bd7eb52022-12-21T20:34:26Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422018-07-01907656910.26442/terarkh201890765-6929535Maternal incompatibilities with fetal human platelet alloantigens -1a, -1b and -15 are the main causes of neonatal alloimmune thrombocytopenia in RussiaS G KHASPEKOVA0L L GOLOVKINA1E K DONUSH2N V GOLUBEVA3O N SHUSTOVA4A V MAZUROV5National Medical Research Center for Cardiology, Russian Ministry of HealthNational Medical Research Center for Hematology, Russian Ministry of HealthRussian Pediatric Clinical Hospital, Russian Ministry of HealthNational Medical Research Center for Cardiology, Russian Ministry of HealthNational Medical Research Center for Cardiology, Russian Ministry of HealthNational Medical Research Center for Cardiology, Russian Ministry of HealthThe aim. Mechanisms underlying the development of neonatal alloimmune thrombocytopenia (NAIT) in in Russia have been studied. Materials and methods. Genetic polymorphisms of human platelet alloantigens (HPA) -1, -2, -3, -4, -5, and -15 were evaluated in 27 families having the newborns with NAIT. NAIT was diagnosed according to the following criteria: (1) newborn with thrombocytopenia; (2) mother with no thrombocytopenia and no increase of platelet associated IgG, (3) presence of antibodies reacting with paternal platelets in maternal plasma / serum. HPA genotyping revealed incompatibilities in 23 out of 27 tested families. In these 23 families HPA-1 conflicts were detected in 16 ones (70%). In 8 cases mothers were homozygous carriers of rare HPA-1b allele and in another 8 cases - of HPA-1a allele which cased incompatibilities with fetal HPA-1a and HPA-1b respectively. In 5 out of 23 families (22%) there were incompatibilities with fetal HPA-15 (HPA-15a, n=2 and HPA-15b, n=3), in 1 family - with HPA-5b (4%), and in 1 family - with HPA-3b (4%) alloantigens. In conclusion the main causes of NAIT in Russia were HPA-1a and -1b conflicts and HPA-15 conflicts were the second frequent ones.https://ter-arkhiv.ru/0040-3660/article/viewFile/32783/pdfplateletsneonatal alloimmune thrombocytopeniahuman platelet alloantigensrussian population |
| spellingShingle | S G KHASPEKOVA L L GOLOVKINA E K DONUSH N V GOLUBEVA O N SHUSTOVA A V MAZUROV Maternal incompatibilities with fetal human platelet alloantigens -1a, -1b and -15 are the main causes of neonatal alloimmune thrombocytopenia in Russia Терапевтический архив platelets neonatal alloimmune thrombocytopenia human platelet alloantigens russian population |
| title | Maternal incompatibilities with fetal human platelet alloantigens -1a, -1b and -15 are the main causes of neonatal alloimmune thrombocytopenia in Russia |
| title_full | Maternal incompatibilities with fetal human platelet alloantigens -1a, -1b and -15 are the main causes of neonatal alloimmune thrombocytopenia in Russia |
| title_fullStr | Maternal incompatibilities with fetal human platelet alloantigens -1a, -1b and -15 are the main causes of neonatal alloimmune thrombocytopenia in Russia |
| title_full_unstemmed | Maternal incompatibilities with fetal human platelet alloantigens -1a, -1b and -15 are the main causes of neonatal alloimmune thrombocytopenia in Russia |
| title_short | Maternal incompatibilities with fetal human platelet alloantigens -1a, -1b and -15 are the main causes of neonatal alloimmune thrombocytopenia in Russia |
| title_sort | maternal incompatibilities with fetal human platelet alloantigens 1a 1b and 15 are the main causes of neonatal alloimmune thrombocytopenia in russia |
| topic | platelets neonatal alloimmune thrombocytopenia human platelet alloantigens russian population |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/32783/pdf |
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