Recent Advances in CAR T-Cell Therapy for Patients with Chronic Lymphocytic Leukemia
Chimeric antigen receptor T cells (CAR T cells) have resulted in dramatic treatment responses for patients with hematologic malignancies, resulting in improved survival for patients with intractable disease. The first patient treated with CD19 directed CAR T cell therapy had chronic lymphocytic leuk...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/7/1715 |
| _version_ | 1797440170339860480 |
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| author | Benjamin M. Heyman Dimitrios Tzachanis Thomas J. Kipps |
| author_facet | Benjamin M. Heyman Dimitrios Tzachanis Thomas J. Kipps |
| author_sort | Benjamin M. Heyman |
| collection | DOAJ |
| description | Chimeric antigen receptor T cells (CAR T cells) have resulted in dramatic treatment responses for patients with hematologic malignancies, resulting in improved survival for patients with intractable disease. The first patient treated with CD19 directed CAR T cell therapy had chronic lymphocytic leukemia (CLL) and achieved a complete remission. Subsequent clinical trials have focused largely on patients with other B-cell hematologic malignancies, owing to the fact that CAR T cell therapy for patients with CLL has met with challenges. More recent clinical trials have demonstrated CAR T cell therapy can be well tolerated and effective for patients with CLL, making it a potential treatment option for patients with this disease. In this article we review the background on CAR T cells for the treatment of patients with CLL, focusing on the unique obstacles that patients with CLL present for the development of adoptive T cell therapy, and the novel approaches currently under development to overcome these hurdles. |
| first_indexed | 2024-03-09T12:04:15Z |
| format | Article |
| id | doaj.art-f99cd8ad56d143ae933c21d550385876 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T12:04:15Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-f99cd8ad56d143ae933c21d5503858762023-11-30T23:01:02ZengMDPI AGCancers2072-66942022-03-01147171510.3390/cancers14071715Recent Advances in CAR T-Cell Therapy for Patients with Chronic Lymphocytic LeukemiaBenjamin M. Heyman0Dimitrios Tzachanis1Thomas J. Kipps2Division of Regenerative Medicine, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USADivision of Blood and Marrow Transplantation, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USACenter for Novel Therapeutics, Department of Medicine, University of California San Diego, La Jolla, CA 92037, USAChimeric antigen receptor T cells (CAR T cells) have resulted in dramatic treatment responses for patients with hematologic malignancies, resulting in improved survival for patients with intractable disease. The first patient treated with CD19 directed CAR T cell therapy had chronic lymphocytic leukemia (CLL) and achieved a complete remission. Subsequent clinical trials have focused largely on patients with other B-cell hematologic malignancies, owing to the fact that CAR T cell therapy for patients with CLL has met with challenges. More recent clinical trials have demonstrated CAR T cell therapy can be well tolerated and effective for patients with CLL, making it a potential treatment option for patients with this disease. In this article we review the background on CAR T cells for the treatment of patients with CLL, focusing on the unique obstacles that patients with CLL present for the development of adoptive T cell therapy, and the novel approaches currently under development to overcome these hurdles.https://www.mdpi.com/2072-6694/14/7/1715CAR T cellschronic lymphocytic leukemianovel approaches |
| spellingShingle | Benjamin M. Heyman Dimitrios Tzachanis Thomas J. Kipps Recent Advances in CAR T-Cell Therapy for Patients with Chronic Lymphocytic Leukemia Cancers CAR T cells chronic lymphocytic leukemia novel approaches |
| title | Recent Advances in CAR T-Cell Therapy for Patients with Chronic Lymphocytic Leukemia |
| title_full | Recent Advances in CAR T-Cell Therapy for Patients with Chronic Lymphocytic Leukemia |
| title_fullStr | Recent Advances in CAR T-Cell Therapy for Patients with Chronic Lymphocytic Leukemia |
| title_full_unstemmed | Recent Advances in CAR T-Cell Therapy for Patients with Chronic Lymphocytic Leukemia |
| title_short | Recent Advances in CAR T-Cell Therapy for Patients with Chronic Lymphocytic Leukemia |
| title_sort | recent advances in car t cell therapy for patients with chronic lymphocytic leukemia |
| topic | CAR T cells chronic lymphocytic leukemia novel approaches |
| url | https://www.mdpi.com/2072-6694/14/7/1715 |
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