Survival times of HIV/AIDS in different AIDS Diagnostic and Treatment Guidelines from 2006 to 2020 in Liuzhou, China
Abstract Background To compare the survival rates of four timing of treatment initiation for people living with HIV/AIDS provided in China in 2006, 2011, 2015, and 2018, and to investigate the factors impacting survival time. Methods A people living with HIV/AIDS retrospective cohort study was in Li...
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BMC
2023-09-01
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| Series: | BMC Public Health |
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| Online Access: | https://doi.org/10.1186/s12889-023-15662-3 |
| _version_ | 1797451238893158400 |
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| author | Susu Ke Quan Fang Jianguo Lan Nini Qiao Xinhong Zhang Changping Xie Yinguang Fan |
| author_facet | Susu Ke Quan Fang Jianguo Lan Nini Qiao Xinhong Zhang Changping Xie Yinguang Fan |
| author_sort | Susu Ke |
| collection | DOAJ |
| description | Abstract Background To compare the survival rates of four timing of treatment initiation for people living with HIV/AIDS provided in China in 2006, 2011, 2015, and 2018, and to investigate the factors impacting survival time. Methods A people living with HIV/AIDS retrospective cohort study was in Liuzhou City from April 2006 to December 2020. The information was obtained from the National Comprehensive AIDS Prevention and Control Information System. Life tables and the Kaplan–Meier method were used to calculate participant survival rates and time. The univariate and multivariate Cox regression models were used to investigate the factors related to survival. Results 18,543 participants were included in this study. In four periods, the 1-year survival rates were 81%, 87%, 95%, and 95%. The 2-year survival rates were 76%, 85%, 93%, and 94%. The 3-year survival rates were 73%, 84%, 92%, and 94%. Results of multivariate Cox regression showed that sex, age of HIV diagnosis, ethnicity, household registration, occupation, marital status, the timing of treatment, education level, route of HIV transmission, whether receiving antiretroviral therapy (ART), and the count of CD4+T cells at baseline (count of CD4+T cells at HIV diagnosis) were factors that are significantly correlated with mortality caused by HIV infection. Conclusions With the Guidelines updated from 2006 to 2020, the 1-, 2-, and 3-year survival rates of people living with HIV/AIDS in four periods tended to increase. The timing of treatment initiation of the updated edition of the AIDS Diagnostic and Treatment Guidelines (Guidelines) significantly prolonged the survival time of people living with HIV/AIDS. |
| first_indexed | 2024-03-09T14:51:50Z |
| format | Article |
| id | doaj.art-f99df74769214cfdb6816bacbc049903 |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-03-09T14:51:50Z |
| publishDate | 2023-09-01 |
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| series | BMC Public Health |
| spelling | doaj.art-f99df74769214cfdb6816bacbc0499032023-11-26T14:28:28ZengBMCBMC Public Health1471-24582023-09-0123111010.1186/s12889-023-15662-3Survival times of HIV/AIDS in different AIDS Diagnostic and Treatment Guidelines from 2006 to 2020 in Liuzhou, ChinaSusu Ke0Quan Fang1Jianguo Lan2Nini Qiao3Xinhong Zhang4Changping Xie5Yinguang Fan6Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical UniversityLiuzhou Center for Disease Control and PreventionDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical UniversityLiuzhou Center for Disease Control and PreventionDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical UniversityAbstract Background To compare the survival rates of four timing of treatment initiation for people living with HIV/AIDS provided in China in 2006, 2011, 2015, and 2018, and to investigate the factors impacting survival time. Methods A people living with HIV/AIDS retrospective cohort study was in Liuzhou City from April 2006 to December 2020. The information was obtained from the National Comprehensive AIDS Prevention and Control Information System. Life tables and the Kaplan–Meier method were used to calculate participant survival rates and time. The univariate and multivariate Cox regression models were used to investigate the factors related to survival. Results 18,543 participants were included in this study. In four periods, the 1-year survival rates were 81%, 87%, 95%, and 95%. The 2-year survival rates were 76%, 85%, 93%, and 94%. The 3-year survival rates were 73%, 84%, 92%, and 94%. Results of multivariate Cox regression showed that sex, age of HIV diagnosis, ethnicity, household registration, occupation, marital status, the timing of treatment, education level, route of HIV transmission, whether receiving antiretroviral therapy (ART), and the count of CD4+T cells at baseline (count of CD4+T cells at HIV diagnosis) were factors that are significantly correlated with mortality caused by HIV infection. Conclusions With the Guidelines updated from 2006 to 2020, the 1-, 2-, and 3-year survival rates of people living with HIV/AIDS in four periods tended to increase. The timing of treatment initiation of the updated edition of the AIDS Diagnostic and Treatment Guidelines (Guidelines) significantly prolonged the survival time of people living with HIV/AIDS.https://doi.org/10.1186/s12889-023-15662-3Antiretroviral therapySurvival timeCox regression modelPeople living with HIV/AIDSInfluencing factors |
| spellingShingle | Susu Ke Quan Fang Jianguo Lan Nini Qiao Xinhong Zhang Changping Xie Yinguang Fan Survival times of HIV/AIDS in different AIDS Diagnostic and Treatment Guidelines from 2006 to 2020 in Liuzhou, China BMC Public Health Antiretroviral therapy Survival time Cox regression model People living with HIV/AIDS Influencing factors |
| title | Survival times of HIV/AIDS in different AIDS Diagnostic and Treatment Guidelines from 2006 to 2020 in Liuzhou, China |
| title_full | Survival times of HIV/AIDS in different AIDS Diagnostic and Treatment Guidelines from 2006 to 2020 in Liuzhou, China |
| title_fullStr | Survival times of HIV/AIDS in different AIDS Diagnostic and Treatment Guidelines from 2006 to 2020 in Liuzhou, China |
| title_full_unstemmed | Survival times of HIV/AIDS in different AIDS Diagnostic and Treatment Guidelines from 2006 to 2020 in Liuzhou, China |
| title_short | Survival times of HIV/AIDS in different AIDS Diagnostic and Treatment Guidelines from 2006 to 2020 in Liuzhou, China |
| title_sort | survival times of hiv aids in different aids diagnostic and treatment guidelines from 2006 to 2020 in liuzhou china |
| topic | Antiretroviral therapy Survival time Cox regression model People living with HIV/AIDS Influencing factors |
| url | https://doi.org/10.1186/s12889-023-15662-3 |
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