Conditional deletion of glucocorticoid receptors in rat brain results in sex-specific deficits in fear and coping behaviors

Conditional deletion of glucocorticoid receptors in rat brain results in sex-specific deficits in fear and coping behaviors

Glucocorticoid receptors (GR) have diverse functions relevant to maintenance of homeostasis and adaptation to environmental challenges. Understanding the importance of tissue-specific GR function in physiology and behavior has been hampered by near-ubiquitous localization in brain and body. Here we...

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Bibliographic Details
Main Authors: Jessie R Scheimann, Rachel D Moloney, Parinaz Mahbod, Rachel L Morano, Maureen Fitzgerald, Olivia Hoskins, Benjamin A Packard, Evelin M Cotella, Yueh-Chiang Hu, James P Herman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-07-01
Series:eLife
Subjects:
CRISPR/Cas9
glucocorticoid receptor
Sprague Dawley
prefrontal cortex
sex difference
Online Access:https://elifesciences.org/articles/44672

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