Asymmetric Synthesis of Axially Chiral Molecules via Organocatalytic Cycloaddition and Cyclization Reactions
Atropisomeric molecules are present in many natural products, biologically active compounds, chiral ligands and catalysts. Many elegant methodologies have been developed to access axially chiral molecules. Among them, organocatalytic cycloaddition and cyclization have attracted much attention becaus...
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| Format: | Article |
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MDPI AG
2023-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/11/4306 |
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| author | Wei-Yun Cai Qian-Ni Ding Ling Zhou Jie Chen |
| author_facet | Wei-Yun Cai Qian-Ni Ding Ling Zhou Jie Chen |
| author_sort | Wei-Yun Cai |
| collection | DOAJ |
| description | Atropisomeric molecules are present in many natural products, biologically active compounds, chiral ligands and catalysts. Many elegant methodologies have been developed to access axially chiral molecules. Among them, organocatalytic cycloaddition and cyclization have attracted much attention because they have been widely used in the asymmetric synthesis of biaryl/heterobiaryls atropisomers via construction of carbo- and hetero-cycles. This strategy has undoubtedly become and will continue to be a hot topic in the field of asymmetric synthesis and catalysis. This review aims to highlight the recent advancements in this field of atropisomer synthesis by using different organocatalysts in cycloaddition and cyclization strategies. The construction of each atropisomer, its possible mechanism, the role of catalysts, and its potential applications are illustrated. |
| first_indexed | 2024-03-11T03:02:11Z |
| format | Article |
| id | doaj.art-f9a1a6831f0c488492567c6ed48707ed |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T03:02:11Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f9a1a6831f0c488492567c6ed48707ed2023-11-18T08:14:49ZengMDPI AGMolecules1420-30492023-05-012811430610.3390/molecules28114306Asymmetric Synthesis of Axially Chiral Molecules via Organocatalytic Cycloaddition and Cyclization ReactionsWei-Yun Cai0Qian-Ni Ding1Ling Zhou2Jie Chen3Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi’an 710127, ChinaKey Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi’an 710127, ChinaKey Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi’an 710127, ChinaKey Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi’an 710127, ChinaAtropisomeric molecules are present in many natural products, biologically active compounds, chiral ligands and catalysts. Many elegant methodologies have been developed to access axially chiral molecules. Among them, organocatalytic cycloaddition and cyclization have attracted much attention because they have been widely used in the asymmetric synthesis of biaryl/heterobiaryls atropisomers via construction of carbo- and hetero-cycles. This strategy has undoubtedly become and will continue to be a hot topic in the field of asymmetric synthesis and catalysis. This review aims to highlight the recent advancements in this field of atropisomer synthesis by using different organocatalysts in cycloaddition and cyclization strategies. The construction of each atropisomer, its possible mechanism, the role of catalysts, and its potential applications are illustrated.https://www.mdpi.com/1420-3049/28/11/4306organocatalyticcycloaddition and cyclizationatropisomer constructionaxial chirality |
| spellingShingle | Wei-Yun Cai Qian-Ni Ding Ling Zhou Jie Chen Asymmetric Synthesis of Axially Chiral Molecules via Organocatalytic Cycloaddition and Cyclization Reactions Molecules organocatalytic cycloaddition and cyclization atropisomer construction axial chirality |
| title | Asymmetric Synthesis of Axially Chiral Molecules via Organocatalytic Cycloaddition and Cyclization Reactions |
| title_full | Asymmetric Synthesis of Axially Chiral Molecules via Organocatalytic Cycloaddition and Cyclization Reactions |
| title_fullStr | Asymmetric Synthesis of Axially Chiral Molecules via Organocatalytic Cycloaddition and Cyclization Reactions |
| title_full_unstemmed | Asymmetric Synthesis of Axially Chiral Molecules via Organocatalytic Cycloaddition and Cyclization Reactions |
| title_short | Asymmetric Synthesis of Axially Chiral Molecules via Organocatalytic Cycloaddition and Cyclization Reactions |
| title_sort | asymmetric synthesis of axially chiral molecules via organocatalytic cycloaddition and cyclization reactions |
| topic | organocatalytic cycloaddition and cyclization atropisomer construction axial chirality |
| url | https://www.mdpi.com/1420-3049/28/11/4306 |
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